Results 51 to 60 of about 571,282 (185)

The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients

Revista Cubana de Medicina Militar, 2022
Introduction: Some gene mutations in high grade glioma patients have many implications in prognosis and treatment response. Objectives: To describe the characteristics and associations of IDH, TP53 gene mutations and MGMT methylation status with some ...
Duc Anh Tran, Ba Van Nguyen, Bac Thanh Nguyen, Hoe Van Vu, Lien Duc Nguyen   +4 more
doaj  

Association between altered metabolism and genetic mutations in human glioma

Cancer Reports, 2023
Background Molecular markers for classification of gliomas include isocitrate dehydrogenase (IDH) mutations and codeletion of chromosomal arms 1p and 19q (1p/19q).
Hannah Pearl, Candace C. Fleischer
doaj   +1 more source

Understanding the Role of IDH Mutation in Chondrosarcoma [PDF]

, 2019
Chondrosarcomas constitute a heterogeneous group of malignant bone tumors that produce hyaline cartilaginous matrix. Chondrosarcomas are generally resistant to conventional chemotherapy and radiotherapy, leaving surgery as the only curative treatment ...
Li, Luyuan
core   +2 more sources

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Multivariate model of MLKL expression controlled by IDH mutation/codeletion status and age at diagnosis.

, 2023
Multivariate model of MLKL expression controlled by IDH mutation/codeletion status and age at diagnosis.
Gisele Cristine Eugenio (16914038), Elivane da Silva Victor (3797524), Ricardo Weinlich (5780201), Suzana Maria Fleury Malheiros (16914041), Guilherme Afonso Vergara (16914035)   +4 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Visualization of tumor heterogeneity and prediction of isocitrate dehydrogenase mutation status for human gliomas using multiparametric physiologic and metabolic MRI

Scientific Reports, 2022
This study aimed to differentiate isocitrate dehydrogenase (IDH) mutation status with the voxel-wise clustering method of multiparametric magnetic resonance imaging (MRI) and to discover biological underpinnings of the clusters.
Akifumi Hagiwara, Hiroyuki Tatekawa, Jingwen Yao, Catalina Raymond, Richard Everson, Kunal Patel, Sergey Mareninov, William H. Yong, Noriko Salamon, Whitney B. Pope, Phioanh L. Nghiemphu, Linda M. Liau, Timothy F. Cloughesy, Benjamin M. Ellingson   +13 more
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Preoperative and Noninvasive Prediction of Gliomas Histopathological Grades and IDH Molecular Types Using Multiple MRI Characteristics

Frontiers in Oncology, 2022
Background and PurposeGliomas are one of the most common tumors in the central nervous system. This study aimed to explore the correlation between MRI morphological characteristics, apparent diffusion coefficient (ADC) parameters and pathological grades,
Ningfang Du, Xiaotao Zhou, Renling Mao, Weiquan Shu, Li Xiao, Yao Ye, Xinxin Xu, Yilang Shen, Guangwu Lin, Xuhao Fang, Shihong Li   +10 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source