Results 211 to 220 of about 207,794 (393)

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

open access: yesCell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu   +5 more
wiley   +1 more source

Cognitive function in idiopathic pulmonary fibrosis [PDF]

open access: bronze, 2015
M Borş   +4 more
openalex   +1 more source

Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics

open access: yesDevelopment, Growth &Differentiation, EarlyView.
ABSTRACT Throughout our lifespan, sustaining orderly morphological structures for ensuring proper functioning of organs is imperative. Among these structures, the extracellular matrix (ECM) plays a pivotal role in sustaining organ and tissue homeostasis. Nevertheless, elucidating the role of abnormal ECM‐induced biomechanical microenvironmental changes
Hirotaka Tao
wiley   +1 more source

A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered ‘early’?

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Timely recognition of inflammatory and autoimmune rheumatic diseases (IARDs) is important to optimize the early diagnosis with tailored interventions and possible prevention of irreversible organ damage. This narrative review provides an update by summarizing the advances in identifying the early stages of rheumatoid arthritis, systemic sclerosis and ...
Elvis Hysa   +7 more
wiley   +1 more source

Fibroblast‐driven MMP‐9/TIMP‐1 imbalance in bronchoalveolar lavage reflects fibrotic progression in interstitial lung disease

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Abstract Background Interstitial lung diseases (ILDs) are characterized by progressive fibrosis, in which extracellular matrix remodelling is regulated by matrix metalloproteinases (MMPs) and their inhibitors (TIMPs). The MMP‐9/TIMP‐1 balance has been implicated in fibrogenesis, but its role in human ILD remains incompletely defined.
Maria Bertolotto   +13 more
wiley   +1 more source

Supplementary Material for: Insights from the German Compassionate Use Program of Nintedanib for the Treatment of Idiopathic Pulmonary Fibrosis

open access: green, 2016
Francesco Bonella   +8 more
openalex   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

open access: yesThe FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza   +4 more
wiley   +1 more source

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