Results 211 to 220 of about 106,594 (302)

Advances in Erectile Dysfunction Management: What Does Work

open access: yesTrends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent and multifactorial disorder that substantially affects quality of life. Pathophysiology includes vascular, neurogenic, drug‐induced, and psychogenic causes, and frequently coexists with cardiometabolic disease.
Jolie Shen   +3 more
wiley   +1 more source

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti   +14 more
wiley   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

open access: yesImmunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Dilated Cardiomyopathy and Aortic Thrombosis in a Capuchin Monkey (Sapajus apella)

open access: yesJournal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT This case report describes a capuchin monkey (Sapajus apella) that presented with bilateral paralysis and cold hind limbs. Clinical examination, including ultrasound imaging, revealed dilated cardiomyopathy and aortic thrombosis. Macroscopic, histopathological, and immunohistochemical analyses confirmed these findings.
Christiane Helm   +3 more
wiley   +1 more source

Wnt3-mediated fibrosis and carcinogenesis of lung squamous cell carcinoma in idiopathic pulmonary fibrosis. [PDF]

open access: yesiScience
Matsuoka A   +24 more
europepmc   +1 more source

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

open access: yesThe FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda   +5 more
wiley   +1 more source

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