Results 141 to 150 of about 18,680 (231)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, Volume 81, Issue 9, Page 3221-3235, September 2026.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, Volume 81, Issue 9, Page 3300-3317, September 2026.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Compensatory pathways in tryptophan metabolism and immune regulation following IDO inhibition. [PDF]

Mol Biol Rep
Gontijo I, Camurça M, Kfoury JR.
europepmc   +1 more source

Tanshinone IIA restores CD8⁺ T-cell immunity in TNBC by suppressing the IDO1-kynurenine axis. [PDF]

Front Pharmacol
Qiu Z, Meng C, Tang M.
europepmc   +1 more source

Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy. [PDF]

Sci Adv
Jiang T, Huang X, Wu Z, Abudusaimaiti G, Song Y, Duan H, Zhou Y, Chen Y, Du S, Zhang H, Qian J, Zhang Y.   +11 more
europepmc   +1 more source

Spatial habitat radiomics predicts tertiary lymphoid structure status and identifies an IDO1⁺ migratory dendritic cell axis in breast cancer. [PDF]

J Immunother Cancer
Yu Y, Wang Q, Lin Y, Huang K, Wang R, Wang J, Huang X, Zhang J, Chen W, Chen R, Chen X, Meng F, Zhang H, Yuan J, Lin J, Song C.   +15 more
europepmc   +1 more source

IDO1 Inhibitor PF-06840003 [PDF]

, 2020
openaire   +1 more source

Phytochemical Modulation of the Kynurenine Pathway (KYNP) and Its Emerging Mechanistic Insights into Cancer Progression: A Systematic Review. [PDF]

Int J Mol Sci
Tsantila EM, Christodoulou MC, Esslinger N, Neophytou CM.   +3 more
europepmc   +1 more source

Abstract 4280 IDO1 and IDO1-AS lncRNA modulation of inflammation, tryptophan catabolism, and immunotherapy

Journal of Biological Chemistry
Subhrangsu Mandal, Avisankar Chini, Prarthana Guha, Ashcharya Rishi, Nagashree Bhat, Pavankumar Gondrala, Mandira Saha, Bao Nhi Nguyen, Princess Chukwukelu   +8 more
openaire   +1 more source