Results 121 to 130 of about 18,680 (231)

Integrated analyses reveal IDO1 as a prognostic biomarker coexpressed with PD-1 on tumor-associated macrophages in esophageal squamous cell carcinoma

Frontiers in Pharmacology
BackgroundInhibition of indolamine-2,3-dioxygenase 1 (IDO1) has been proposed as a promising strategy for cancer immunotherapy; however, it has failed in clinical trials.
Yaojun Peng, Yaojun Peng, Lingxiong Wang, Lingxiong Wang, Juan Yang, Qiyan Wu, Qiyan Wu, Xiaoxuan Sun, Xiaoxuan Sun, Jinying Zhang, Yanju Yu, Liping Zhang, Jie Gao, Qing Zhou, Haiyan Zhu, Fan Yin   +15 more
doaj   +1 more source

The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition

Acta Pharmaceutica Sinica B
The pathogenesis of pulmonary fibrosis (PF) is complex. It is characterized by myofibroblast hyperplasia and deposition of collagen protein. Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in lung fibroblasts and epithelial cells, but its functions in ...
Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, Ting Zhu, Louqian Zhang, Chaofeng Zhang   +6 more
doaj   +1 more source

Divergent Clonal Trajectories of FLT3‐ITD in Acute Myeloid Leukemia and Their Clinical and Transcriptomic Associations

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT FLT3‐ITD occurs in approximately 20%–25% of cases of adult AML and is associated with increased relapse risk and shorter survival. FLT3‐ITD status informs AML risk at diagnosis, but its dynamic changes during disease evolution are not well defined.
Xavier Cheng‐Hong Tsai, Yu‐Sung Chang, Feng‐Ming Tien, Min‐Yen Lo, Yuan‐Yeh Kuo, Mei‐Hsuan Tseng, Yen‐Ling Peng, Chi‐Yuan Yao, Szu‐Chi Yao, Chien‐Chin Lin, Bor‐Sheng Ko, Ming Yao, Hwei‐Fang Tien, Hsin‐An Hou, Wen‐Chien Chou   +14 more
wiley   +1 more source

IDO1 inhibitor enhances the effectiveness of PD-1 blockade in microsatellite stable colorectal cancer by promoting macrophage pro-inflammatory phenotype polarization

Cancer Immunology, Immunotherapy
Microsatellite stable (MSS) colorectal cancer (CRC) is a subtype of CRC that generally exhibits resistance to immunotherapy, particularly immune checkpoint inhibitors such as PD-1 blockade. This study investigates the effects and underlying mechanisms of
Lv Guangzhao, Wang Xin, Wu Miaoqing, Ma Wenjuan, Liu Ranyi, Pan Zhizhong, Zhang Rongxin, Chen Gong   +7 more
doaj   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

IDO1 Gene [PDF]

, 2020
openaire   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Ido1 knock-out 마우스를 이용한 Dextran Sulfate Sodium 유도 대장염 모델에서의 전사체 분석 [PDF]

, 2014
학위논문 (석사)-- 서울대학교 대학원 : 식품영양학과, 2014. 8. 신동미.Tryptophan involves in a range of biological processes including protein and biogenic nitrogen-compounds synthesis.
손우정
core  

Additional file 1: of miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy

, 2018
Figure S1. IDO1 was induced by IFN-γ. IDO1 was induced by IFN-γ. (A) IDO1 expression of A549 and DLD-1 stimulated by 1-300 ng/ml IFN-γ for 24 h. IDO1 expression was measured using flow cytometry.
Munish Kumar (4410217), Mingzhi Zhang (216851), Zhiyuan Zhou (350818), Ling Li (38566), Qing Yi (495197), Yong Lu (19136), Jiajia Xia (176414), Yong Li (15029), Qian Huang (127640), Xu Wang (28596), Qipan Deng (5132810), Ken Young (5132813), Lei Wang (6656), Zhaoyang Zeng (129701), Xiaodong Ma (1620535)   +14 more
core   +1 more source

Fetal Pathogenesis of Scoliosis Suggested by Asymmetry of Gene Expression in Paravertebral Muscles

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The dysfunction of paravertebral muscles may contribute to the development of idiopathic scoliosis. Several candidate genes have been linked to scoliosis, but the underlying mechanisms and cell types remain unclear. Methods We initially included 40 idiopathic scoliosis cases and 19 controls. Muscle biopsies were obtained bilaterally
Tian Cheng, Gamze Yazgeldi Gunaydin, Elisabet Einarsdottir, Sini Ezer, Juha Kere, Shintaro Katayama, Paul Gerdhem   +6 more
wiley   +1 more source