Results 1 to 10 of about 2,002 (149)

Assessment of Cidofovir for Treatment of Ocular Bovine Herpesvirus-1 Infection in Cattle Using an Ex-Vivo Model [PDF]

Viruses, 2021
Bovine herpesvirus-1 (BoHV-1) infection contributes to keratoconjunctivitis, respiratory disease, and reproductive losses in cattle. The objective of this study was to determine the most appropriate ophthalmic antiviral agent for BoHV-1 inhibition using ...
Christopher R. Alling, Chin-Chi Liu, Ingeborg M. Langohr, Muzammel Haque, Renee T. Carter, Rose E. Baker, Andrew C. Lewin   +6 more
doaj   +2 more sources

Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease. [PDF]

PLoS ONE
Induction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other β-hemoglobinopathies.
Jian-Ping Yang, Rachel Toughiri, Anshu P Gounder, Dan Scheibe, Matt Petrus, Sarah J Fink, Sebastien Vallee, Jon Kenniston, Nikolaos Papaioannou, Steve Langston, Narender R Gavva, Shane R Horman   +11 more
doaj   +2 more sources

A Screening Study Identified Decitabine as an Inhibitor of Equid Herpesvirus 4 That Enhances the Innate Antiviral Response [PDF]

Viruses
Equid herpesvirus 4 (EHV-4) is a common respiratory pathogen in horses. It sporadically induces abortion or neonatal death. Although its contribution in neurological disorders is not clearly demonstrated, there is a strong suspicion of its involvement ...
Camille Normand, Côme J. Thieulent, Christine Fortier, Gabrielle Sutton, Catherine Senamaud-Beaufort, Laurent Jourdren, Corinne Blugeon, Pierre-Olivier Vidalain, Stéphane Pronost, Erika S. Hue   +9 more
doaj   +2 more sources

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. [PDF]

PLoS ONE, 2012
To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase;
Louise Egeblad, Martin Welin, Susanne Flodin, Susanne Gräslund, Liya Wang, Jan Balzarini, Staffan Eriksson, Pär Nordlund   +7 more
doaj   +10 more sources

Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [PDF]

PLoS Pathogens
Lumpy skin disease (LSD) is an emerging transboundary disease caused by lumpy skin disease virus (LSDV), posing significant threats to global cattle health in the absence of validated drugs. Here, we constructed a recombinant LSDV (rLSDV) expressing both
Zuxin Gong, Jiaqi Dai, Hailong Qu, Yongxin Hu, Fanqi Sun, Chenchen Liu, Xin Li, Chunyan Feng, Zhiliang Wang, Zhen Yang, Gongguan Liu   +10 more
doaj   +2 more sources

VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions

Biomedicines, 2023
Monkeypox disease (Mpox) has threatened humankind worldwide since mid-2022. The Mpox virus (MpoxV) is an example of Orthopoxviruses (OPVs), which share similar genomic structures. A few treatments and vaccines are available for Mpox.
Shuaibu A. Hudu, Ahmed S. Alshrari, Aiman Al Qtaitat, Mohd Imran   +3 more
doaj   +1 more source

Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses

Viruses, 2010
The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with ...
Mark N. Prichard, Earl R. Kern
doaj   +1 more source

Treatment of eczema herpeticum with acyclovir [PDF]

, 1983
Contains fulltext : 4421.pdf (publisher's version ) (Open ...
Enschedé, F.A.J., Meer, J.W.M. van der, Swart, R.N.J., Vermeer, B.J., Versteeg, J.   +4 more
core   +5 more sources

Nanoindentation of HMX and Idoxuridine to Determine Mechanical Similarity

Crystals, 2017
Assessing the mechanical behavior (elastic properties, plastic properties, and fracture phenomena) of molecular crystals is often complicated by the difficulty in preparing samples.
Alexandra C. Burch, John D. Yeager, David F. Bahr   +2 more
doaj   +1 more source

Historical Perspectives in the Development of Antiviral Agents Against Poxviruses

Viruses, 2010
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the ...
Erik De Clercq
doaj   +1 more source