Assessment of Cidofovir for Treatment of Ocular Bovine Herpesvirus-1 Infection in Cattle Using an Ex-Vivo Model [PDF]
Viruses, 2021 Bovine herpesvirus-1 (BoHV-1) infection contributes to keratoconjunctivitis, respiratory disease, and reproductive losses in cattle. The objective of this study was to determine the most appropriate ophthalmic antiviral agent for BoHV-1 inhibition using ...
Christopher R. Alling +6 more
doaj +2 more sources
A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment [PDF]
BMC Ophthalmology, 2015 BackgroundThis objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ulcer sub-types.MethodsData ...
D. Balderson +7 more
core +2 more sources
Definitions, 2020 An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is ...
openaire +2 more sources
Nanoindentation of HMX and Idoxuridine to Determine Mechanical Similarity
Crystals, 2017 Assessing the mechanical behavior (elastic properties, plastic properties, and fracture phenomena) of molecular crystals is often complicated by the difficulty in preparing samples.
Alexandra C. Burch +2 more
doaj +2 more sources
Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease. [PDF]
PLoS ONEInduction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other β-hemoglobinopathies.
Jian-Ping Yang +11 more
doaj +2 more sources
Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. [PDF]
PLoS ONE, 2012 To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase;
Louise Egeblad +7 more
doaj +10 more sources
A Screening Study Identified Decitabine as an Inhibitor of Equid Herpesvirus 4 That Enhances the Innate Antiviral Response [PDF]
VirusesEquid herpesvirus 4 (EHV-4) is a common respiratory pathogen in horses. It sporadically induces abortion or neonatal death. Although its contribution in neurological disorders is not clearly demonstrated, there is a strong suspicion of its involvement ...
Camille Normand +9 more
doaj +2 more sources
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [PDF]
PLoS PathogensLumpy skin disease (LSD) is an emerging transboundary disease caused by lumpy skin disease virus (LSDV), posing significant threats to global cattle health in the absence of validated drugs. Here, we constructed a recombinant LSDV (rLSDV) expressing both
Zuxin Gong +10 more
doaj +2 more sources
Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses [PDF]
Viruses, 2010 The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with ...
Mark N. Prichard, Earl R. Kern
doaj +4 more sources
VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions [PDF]
Biomedicines, 2023 Monkeypox disease (Mpox) has threatened humankind worldwide since mid-2022. The Mpox virus (MpoxV) is an example of Orthopoxviruses (OPVs), which share similar genomic structures. A few treatments and vaccines are available for Mpox.
Shuaibu A. Hudu +3 more
doaj +2 more sources