Results 71 to 80 of about 44,977 (202)

Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
In individuals with type 1 diabetes, immune cell infiltration in the colon mucosa tended to correlate with fecal and systemic markers of intestinal permeability and inflammation, as well as gastrointestinal symptoms. These findings suggest that low‐grade gut immune activation might link the intestinal barrier dysfunction with systemic endotoxin ...
Polina Zalizko, Reinis Isaks, Leonora Pahirko, Aleksejs Fedulovs, Eduards Krustins, Jurijs Nazarovs, Sergejs Dubencovs, Hanne Salmenkari, Markku Lehto, Kaspars Jēkabsons, Una Riekstiņa, Per‐Henrik Groop, Niina Sandholm, Jeļizaveta Sokolovska   +13 more
wiley   +1 more source

Correlation of Serum Immunoglobulin A and Immunoglobulin A / Complement 3 Ratio with IgA Nephropathy: One Year Prospective Study

Journal of Nobel Medical College
Background: IgA nephropathy is the most prevalent primary glomerulonephritis worldwide, characterized by the mesangial deposition of IgA immune complexes.Its clinical course is highly variable, ranging from indolent to rapidly progressive forms, and it ...
Nirajan Mainali, Keshika Kshatree
doaj   +1 more source

Research advances on the pathogenesis of IgA nephropathy

Linchuang shenzangbing zazhi, 2022
IgA nephropathy is the most common primary glomerular disease in the world. Up to 20%-40% of patients develop end-stage renal disease within 20 years after a definite diagnosis of renal biopsy.
Lu Fang-cao, Yuan Hong-ling
doaj  

A case presentation of an IgA nephropathy patient with Vogt-Koyanagi-Harada syndrome

BMC Nephrology, 2020
Background Vogt-Koyanagi-Harada syndrome is a rare disease characterized by skin and eyelash bleaching, chronic granulomatous iridocyclitis and exudative retinal detachment, and aseptic meningitis and encephalopathy.
Quan Zhang, Xing Fan, Meng Tian, Hongling Han   +3 more
doaj   +1 more source

IgA nephropathy and celiac disease: pathogenetic relationship of diseases and the possibility of a gluten-free diet

Лечащий Врач, 2021
According to the world literature IgA nephropathy is most often considered as an idiopathic form of primary glomerulonephritis, however, in some cases, the disease can be secondary and pathogenetically associated with liver diseases (cirrhosis of any ...
M. E. Mantsaeva, A. G. Borisov, M. A. Smirnova, A. A. Stremouhov   +3 more
doaj   +1 more source

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study [PDF]

, 2018
Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN)
Ambruzs, Josephine M., Appel, Gerald B., Bomback, Andrew S., Cai, Yi, Cattran, Daniel C., Chishti, Aftab S., CureGN Consortium, D’Agati, Vivette D., D’Alessandri-Silva, Cynthia J., Falk, Ronald J., Flessner, Michael, Gbadegesin, Rasheed A., Gharavi, Ali G., Gillespie, Brenda W., Gipson, Debbie S., Greenbaum, Larry A., Guay-Woodford, Lisa M., Hogan, Jonathan J., Holzman, Lawrence B., Iragorri, Sandra, Jennette, J. Charles, Julian, Bruce A., Khalid, Myda, Kiryluk, Krzysztof, Kretzler, Matthias, Lafayette, Richard A., Liapis, Helen, Lugani, Francesca, Mansfield, Sarah A., Mason, Sherene, Matar, Raed Bou, Nachman, Patrick H., Nast, Cynthia C., Nester, Carla M., Noone, Damien G., Novak, Jan, O’Shaughnessy, Michelle M., Reich, Heather N., Rheault, Michelle N., Rizk, Dana V., Robinson, Bruce M., Saha, Manish K., Sanghani, Neil S., Selewski, David T., Smoyer, William E., Sperati, C. John, Sreedharan, Rajasree, Srivastava, Tarak, Swiatecka-Urban, Agnieszka, Twombley, Katherine, Vasylyeva, Tetyana L., Weaver, Donald J., Yin, Hong, Zee, Jarcy   +53 more
core   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients

Kidney & Blood Pressure Research, 2018
Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular
Petr Kosztyu, Martin Hill, Jana Jemelkova, Lydie Czernekova, Leona Raskova Kafkova, Miroslav Hruby, Karel Matousovic, Karel Vondrak, Josef Zadrazil, Ivan Sterzl, Jiri Mestecky, Milan Raska   +11 more
doaj   +1 more source

Immunoglobulin A Nephropathy and Malaria falciparum Infection; a Rare Association [PDF]

, 2013
Glomerular involvement occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Here, we report a rare case of falciparum malaria-associated IgA nephropathy.
Alizadeh, Farshid., Ataei, Behrooz., Baradaran, Azar., Nasri, Hamid., Rafieian-Kopaei, Mahmoud.   +4 more
core   +2 more sources