Results 71 to 80 of about 44,747 (232)

Coexisting genetic kidney disease explains many cases of ‘familial’ IgA nephropathy where the proband has biopsy-confirmed mesangial IgA deposits

Frontiers in Medicine
BackgroundOne in seven people with IgA nephropathy has another apparently-affected family member. This study examined how often biopsy-proven familial and sporadic IgA nephropathy were associated with genetic kidney disease.MethodsEleven unrelated people
YuXin Li, Jing Zhang, Zhuo Jun Yin, Ziming Zhou, Bocheng Huang, Khalid Mahmood, Deb Colville, David Barit, Russell Auwardt, Robert Fassett, Kathy Paizis, Francesco Ierino, Timothy Pianta, David Langsford, Mary Huang, Judy Savige   +15 more
doaj   +1 more source

Urinary uromodulin excretion predicts progression of chronic kidney disease resulting from IgA nephropathy. [PDF]

PLoS ONE, 2013
BACKGROUND: Uromodulin, or Tamm-Horsfall protein, is the most abundant urinary protein in healthy individuals. Recent studies have suggested that uromodulin may play a role in chronic kidney diseases.
Jingjing Zhou, Yuqing Chen, Ying Liu, Sufang Shi, Suxia Wang, Xueying Li, Hong Zhang, Haiyan Wang   +7 more
doaj   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Correlation of Serum Immunoglobulin A and Immunoglobulin A / Complement 3 Ratio with IgA Nephropathy: One Year Prospective Study

Journal of Nobel Medical College
Background: IgA nephropathy is the most prevalent primary glomerulonephritis worldwide, characterized by the mesangial deposition of IgA immune complexes.Its clinical course is highly variable, ranging from indolent to rapidly progressive forms, and it ...
Nirajan Mainali, Keshika Kshatree
doaj   +1 more source

Research advances on the pathogenesis of IgA nephropathy

Linchuang shenzangbing zazhi, 2022
IgA nephropathy is the most common primary glomerular disease in the world. Up to 20%-40% of patients develop end-stage renal disease within 20 years after a definite diagnosis of renal biopsy.
Lu Fang-cao, Yuan Hong-ling
doaj  

A case presentation of an IgA nephropathy patient with Vogt-Koyanagi-Harada syndrome

BMC Nephrology, 2020
Background Vogt-Koyanagi-Harada syndrome is a rare disease characterized by skin and eyelash bleaching, chronic granulomatous iridocyclitis and exudative retinal detachment, and aseptic meningitis and encephalopathy.
Quan Zhang, Xing Fan, Meng Tian, Hongling Han   +3 more
doaj   +1 more source

IgA nephropathy and celiac disease: pathogenetic relationship of diseases and the possibility of a gluten-free diet

Лечащий Врач, 2021
According to the world literature IgA nephropathy is most often considered as an idiopathic form of primary glomerulonephritis, however, in some cases, the disease can be secondary and pathogenetically associated with liver diseases (cirrhosis of any ...
M. E. Mantsaeva, A. G. Borisov, M. A. Smirnova, A. A. Stremouhov   +3 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients

Kidney & Blood Pressure Research, 2018
Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular
Petr Kosztyu, Martin Hill, Jana Jemelkova, Lydie Czernekova, Leona Raskova Kafkova, Miroslav Hruby, Karel Matousovic, Karel Vondrak, Josef Zadrazil, Ivan Sterzl, Jiri Mestecky, Milan Raska   +11 more
doaj   +1 more source

Interpretative Phenomenological Study Exploring Why People With Kidney Failure Say ‘No’ to a Kidney Transplant

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To develop an in‐depth understanding of peoples' perceptions and experiences of decision‐making and reasons why they declined the opportunity of a kidney transplant. Design The Theory of Planned Behaviour informed the qualitative interpretative phenomenological analysis. Methods Semi‐structured interviews were conducted between August 2022
Emma Jones, Leah McLaughlin, Kate Shakespeare, Jane Noyes   +3 more
wiley   +1 more source