Results 101 to 110 of about 29,874,260 (303)

scTIDE: Deciphering Critical Transitions Through Cell‐Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching

Advanced Science, EarlyView.
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong, Bowen Niu, Yongbo Yu, Shiyang Nie, Xuerong Gu, Pei Chen, Rui Liu   +6 more
wiley   +1 more source

Sustained IGF-1 Secretion by Adipose-Derived Stem Cells Improves Infarcted Heart Function

Cell Transplantation, 2016
The mechanism by which stem cell-based therapy improves heart function is still unknown, but paracrine mechanisms seem to be involved. Adipose-derived stem cells (ADSCs) secrete several factors, including insulin-like growth factor-1 (IGF-1), which may ...
Luiza L. Bagno, Deivid Carvalho, Fernanda Mesquita, Ruy A. Louzada, Bruno Andrade, Taís H. Kasai-Brunswick, Vivian M. Lago, Grazielle Suhet, Debora Cipitelli, João Pedro Werneck-De-Castro, Antonio C. Campos-De-Carvalho   +10 more
doaj   +1 more source

IGF-1 mediates exercise-induced phospholipid alteration in the murine skin tissues [PDF]

, 2012
We previously demonstrated that exercise with an iso-caloric diet significantly reduced body weight and skin carcinogenesis in correspondence with lower plasma IGF-1 levels and IGF-1-dependent phospholipid signaling.
Su, Xiaoyu, Ma, Haitian, Xu, Jianteng, Wang, Weiqun, Lin, Dingbo, Chen, Jie, Standard, Joseph, Jiang, Yu   +7 more
core   +1 more source

IGF-1-dependent cardiomyocyte hypertrophy requires inhibition of PTP1B by PC1.

, 2021
Cardiomyocytes were transfected with either scrambled (Scr) or PC1 siRNA (siPC1), incubated for 24 h, and then stimulated with IGF-1 (10 nM) in the presence or absence of the PTP1B inhibitor CinnGEL (10 μM).
César Vásquez-Trincado (11292276), Camila López-Crisosto (2179768), Francisco Altamirano (494644), Natalia Torrealba (11292270), Zully Pedrozo (2967186), Carolina Fernández (5994746), Raúl Flores-Vergara (11292279), Sergio Lavandero (159188), María Paz Ocaranza (11292282), Valeria Garrido-Moreno (11292273), Mario Chiong (2179764)   +10 more
core   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling

, 2012
IGF-1 plays an important role in cardiovascular homeostasis, and plasma levels of IGF-1 correlate inversely with systolic function in heart failure. It is not known to what extent circulating IGF-1 secreted by the liver and local autocrine/paracrine IGF ...
Omerovic, Elmir,, Ohlsson, Claes,, Shao, Yangzhen,, Råmunddal, Truls,, Svensson, Johan,, Scharin Täng, Margareta,, Redfors, Björn,, Lindbom, Malin,   +7 more
core   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

Anais da Academia Brasileira de Ciências
Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis.
DANYLO R. COSTA-SILVA, MARIA DA CONCEIÇÃO BARROS-OLIVEIRA, RAFAEL S. BORGES, CLÉCITON B. TAVARES, UMBELINA S. BORGES, FRANCISCO A. ALVES-RIBEIRO, VLADIMIR C. SILVA, BENEDITO B. DA SILVA   +7 more
doaj   +1 more source

IGF-1: Analytik und Referenzbereiche / Measurement of IGF-1 and reference ranges

LaboratoriumsMedizin, 2008
Zusammenfassung Der Insulin-ähnliche Wachstumsfaktor IGF-1 (insulin-like growth factor 1) ist der ausschlaggebende Faktor zur Beurteilung des Wachstumshormonhaushalts. Da der IGF-1-Spiegel zahlreichen Einflüssen wie z. B. dem Alter, Geschlecht, genetischen Faktoren, der Ernährung oder Erkrankungen ausgesetzt ist, ist es notwendig ...
Elisabeth Spilcke-Liss, Nele Friedrich, Henri Wallaschofski   +2 more
openaire   +1 more source

Molecular and cellular effects of insulin-like growth factor-1 and LongR3-IGF-1 on in vitro maturation of bovine oocytes: comparative study

, 2020
Addition effects of insulin-like growth factor-1 (IGF-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (LongR3-IGF-1) after in vitro maturation (IVM) of cattle cumulus-oocyte complexes (COCs) were compared and evaluated on meiotic
Fontes, P. K. [UNESP], Landim-Alvarenga, F. C. [UNESP], Guastali, M. D. [UNESP], Paulini, F., Araujo, M. S. [UNESP], Silva, A. N., Tsunemi, M. H. [UNESP], Castilho, A. C. S. [UNESP]   +7 more
core   +1 more source