T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
IGF-1: Analytik und Referenzbereiche / Measurement of IGF-1 and reference ranges
LaboratoriumsMedizin, 2008 Zusammenfassung Der Insulin-ähnliche Wachstumsfaktor IGF-1 (insulin-like growth factor 1) ist der ausschlaggebende Faktor zur Beurteilung des Wachstumshormonhaushalts. Da der IGF-1-Spiegel zahlreichen Einflüssen wie z. B. dem Alter, Geschlecht, genetischen Faktoren, der Ernährung oder Erkrankungen ausgesetzt ist, ist es notwendig, exakte
Elisabeth Spilcke-Liss +2 more
openaire +1 more source
Advanced Science, EarlyView.ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang +8 more
wiley +1 more source
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
eLife, 2018 Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs.
Yosuke Yoneyama +9 more
doaj +1 more source
IGF-1 enhances the osteogenic activity of BMP-6 in vitro and in vivo [PDF]
, 2017 Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and alternatives are being explored.
Becerra-Ratia, Jose +2 more
core
IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition [PDF]
, 2011 Introduction TGF-β signaling has been extensively studied in many developmental contexts, amongst which is its ability to induce epithelial to mesenchymal transitions (EMT).
Logan A Walsh, Sashko Damjanovski
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Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
Advanced Science, EarlyView.We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source
Sustained IGF-1 Secretion by Adipose-Derived Stem Cells Improves Infarcted Heart Function
Cell Transplantation, 2016 The mechanism by which stem cell-based therapy improves heart function is still unknown, but paracrine mechanisms seem to be involved. Adipose-derived stem cells (ADSCs) secrete several factors, including insulin-like growth factor-1 (IGF-1), which may ...
Luiza L. Bagno +10 more
doaj +1 more source
Avaliação plasmática de igf-1 no prolactinoma IGF-1 plasma levels evaluation in prolactinoma
Arquivos de Neuro-Psiquiatria, 2006 Prolactinomas são os tumores hipofisários mais comuns, podendo co-secretar GH (hormônio do crescimento). IGF-1 (fator de crescimento insulina-símile-1) é o principal responsável pelas ações do GH e parâmetro diagnóstico de acromegalia.
Daniela Zylberberg +5 more
doaj +1 more source
IGF-1 and IGF-1 SDS – fit for purpose? [PDF]
European Journal of Endocrinology, 2019 Kos, S. +7 more
openaire +5 more sources