Results 91 to 100 of about 231,978 (311)

Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study

BMC Psychiatry, 2020
Background IGF-1 is an essential neurotrophin produced peripherally and in the brain. Impairments in the brain IGF-1 concentrations might be responsible for some aspects of major depressive disorder (MDD) pathogenesis, whereas peripheral IGF-1 could have
Oleg A. Levada, Alexandra S. Troyan, Irina Y. Pinchuk   +2 more
doaj   +1 more source

A Novel Single Nucleotide Polymorphism in Exon 4 of Insulin-Like Growth Factor-1 Associated with Production Traits in Bali Cattle [PDF]

, 2012
Insulin-like growth factor-1 (IGF-1) is one of the gene candidates that can be used in selection strategy by using DNA markers (marker assisted selection).
Arman, C. (C), Gurnadi, E. (E), Maskur, M. (Maskur), Muladno, M. (Muladno), Sumantri, C. (C)   +4 more
core  

Вплив експресії гена, що кодує інсуліноподібний фактор росту, на загоєння ран шкіри у мишей зі стрептозотоцин-індукованим діабетом [PDF]

, 2015
Одним із основних факторів, що можуть здійснювати вплив на стан та швидкість процесів регенерації шкіри, є IGF-1 (ген, що кодує інсуліноподібний фактор).
Говорун, М.Ю., Гузик, М.М., Клименко, П.П., Кучмеровська, Т.М., Леонов, Ю.І., Пішель, І.М., Шкумат, М.С.   +6 more
core   +2 more sources

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Fish oil supplementation from 9 to 18 months of age affects the insulin-like growth factor axis in a sex-specific manner in Danish infants [PDF]

, 2016
Several studies have investigated the effects of fish oil (FO) on infant growth, but little is known about the effects of FO and sex on insulin-like growth factor-1 (IGF-1), the main regulator of growth in childhood. We explored whether FOv.
Andersen, Anders D., Damsgaard, Camilla T., Harsløf, Laurine B. S., Hellgren, Lars, Lauritzen, Lotte, Michaelsen, Kim F.   +5 more
core   +2 more sources

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Παθοφυσιολογία του μυοκαρδίου και βιορυθμιστικό σύστημα IGF-1/IGF-1-R [PDF]

, 2014
Ο ινσουλινομιμητικός αυξητικός παράγοντας-1 (IGF-1) εμπλέκεται στην αναδιαμόρφωση του μυοκαρδίου και την υπερτροφία. Δυο IGF-1 mRNA εναλλακτικά μετάγραφα έχουν ανιχνευτεί στα τρωκτικά (IGF-1Ea και MGF). Στη παρούσα διατριβή μελετήσαμε το πρότυπο έκφρασης των ισομορφών του IGF-1 και του υποδοχέα του (IGF-1R) σε διάφορα χρονικά σημεία κατά την διάρκεια ...
openaire   +1 more source

How IGF-1 activates its receptor

eLife, 2014
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We point out an underappreciated dimer in the crystal structure of the related Insulin Receptor (IR) with ...
Jennifer M Kavran, Jacqueline M McCabe, Patrick O Byrne, Mary Katherine Connacher, Zhihong Wang, Alexander Ramek, Sarvenaz Sarabipour, Yibing Shan, David E Shaw, Kalina Hristova, Philip A Cole, Daniel J Leahy   +11 more
openaire   +3 more sources

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. [PDF]

, 2017
Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and ...
A Fantozzi, A Sica, Ainhoa Mielgo, Almudena Santos, B Ruffell, B Weigelt, BA Pulaski, BP Schneider, BZ Qian, C Marquette, Carlos Figueiredo, CD Mills, CJ Aslakson, CT Guy, CX Ma, D Ohlund, Dean Hammond, DF Quail, DF Quail, DG DeNardo, DH Fagan, DL Dexter, EA Rakha, EM Fox, EY Lin, F Klemm, Fiona Campbell, HA Wahba, JB Wyckoff, JE Maglione, JFR Robertson, JL Gooch, K Friedbichler, KA Lodhia, KM Bussard, KR Bauer, L Bingle, L Ireland, Lesley G. Ellies, Lucy Ireland, M Augsten, M Guha, M Pollak, MC Schmid, Michael Schmid, MJ Campbell, OC Olson, PJ Murray, RD Leek, RL Jones, RL Siegel, S Massarweh, SA Davie, SK Denduluri, SM Farabaugh, SR Nielsen, T Shree, TD Schmittgen, Thomas Bogenrieder, Ulrike Weyer-Czernilofsky, V Bronte, WJ Gradishar, XHF Zhang, Y Mao, YH Lu, YH Zhang, YW Wan   +66 more
core   +2 more sources