Results 91 to 100 of about 145,691 (215)

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. [PDF]

Sci Adv
Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Hwang E, Chung CS, Weinert JL, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M.   +20 more
europepmc   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

Neuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García, Edgar Alvarado, Alejandro Cuevas, Laura Valverde, Eduardo Salinas, Kevin O'Hara‐Veintimilla, María Cruz Rodríguez‐Oroz, Miguel Germán Borda   +7 more
wiley   +1 more source

Expression of HSP70, IGF-1, OCT4, and AIF in Clear Cell Renal Cell Carcinoma. [PDF]

Biomedicines
Franić MB, Todorović P, Sedlar IT, Filipović N, Kelam N, Racetin A, Kopilaš A, Huljev AD, Vukojević K.   +8 more
europepmc   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Microglial-Derived IGF-1 Serves as a Regulator for Neuroimmune Homeostasis During Viral-Induced Demyelination. [PDF]

Viruses
Scarfone VM, Pachow C, Nguyen PU, Lakatos A, De La Torre JJ, Xie A, Fernandez K, Collado C, Murray K, Tinoco R, Walsh CM, Owens T, Wlodarczyk A, Lane TE.   +13 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Fatigue Strength in Additive Toolmaking: A Study of Metal Binder Jetting and Electron Beam Melting for Processing Carbide‐Rich Cold‐Work Tool Steels

steel research international, EarlyView.
Focusing on the critical tap hole region of the blast furnace, this work examines binder characteristics, prepares tap hole clay with different formulations, and evaluates their physical properties. The findings confirm the advantages of composite binders and offer a new binder option for tap hole clay.
Frederik Tegeder, Lennart Mirko Scholl, Sandra Wieland, Christian Weck, Marie Franke‐Jurisch, Alexander Bezold, Thomas Weißgärber, Christoph Broeckmann   +7 more
wiley   +1 more source

Prenatal (1-3)IGF-1 Treatment Is Ineffective and Behaviorally Detrimental in a Rat Model of Cortical Malformation. [PDF]

Brain Behav
Lee M, Kim EJ, Yum MS.
europepmc   +1 more source

In Situ Alloying of H13 Tool Steel With TiC via PBF‐LB/M

steel research international, EarlyView.
H13 tool steel is in situ alloyed with titanium carbides (TiC) in amounts up to 30 wt.%. This approach offers the advantage that the carbides melt only partially during processing, preventing excessive carbon enrichment of the steel matrix. The resulting microstructure consists of coarse, undissolved and fine, reprecipitated carbides, leading to grain ...
Oliver Bürgi, Anke Kaletsch, Christoph Broeckmann   +2 more
wiley   +1 more source

Behavioral Therapy Ameliorates Severe Obesity With Low Levels of Plasma GH and IGF-1: A Case Report. [PDF]

Clin Case Rep
Yoshimichi G.
europepmc   +1 more source