Results 81 to 90 of about 29,874,260 (303)

Avaliação plasmática de igf-1 no prolactinoma IGF-1 plasma levels evaluation in prolactinoma

Arquivos de Neuro-Psiquiatria, 2006
Prolactinomas são os tumores hipofisários mais comuns, podendo co-secretar GH (hormônio do crescimento). IGF-1 (fator de crescimento insulina-símile-1) é o principal responsável pelas ações do GH e parâmetro diagnóstico de acromegalia.
Daniela Zylberberg, Erika C.O. Naliato, Alair Sarmet, Eduardo Sato, Fernando S.R. Costa, Alice H.D. Violante   +5 more
doaj   +1 more source

Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain

Brain Research Bulletin, 2018
Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain.
Paul L. Mueller, Carolyn E. Pritchett, Tyler N. Wiechman, Alevtina Zharikov, Andras Hajnal   +4 more
openaire   +2 more sources

Níveis sérico de IGF-I e IGFBP-3 em pacientes admitidos por complicações da cirrose hepática [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Mestrado Profissional Associado à Residência Médica em Cuidados Intensivos e PaliativosIntrodução: IGF-I e IGFBP-3 fazem parte do sistema IGF e, por terem ...
Ronsoni, Marcelo Fernando
core  

Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants

, 2020
Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1 ...
Hellström, Ann,, Klevebro, Susanna, Pivodic, Aldina, Wackernagel, Dirk, Ley, David,, Hansen-Pupp, Ingrid, Smith, Lois,, Hallberg, Boubou, Borg, Jan, Smith, Lois, Klevebro, Susanna,, Hellgren, Gunnel,, Hellgren, Gunnel, Wackernagel, Dirk,, Ley, David, Borg, Jan,, Hallberg, Boubou,, Pivodic, Aldina,, Hansen-Pupp, Ingrid,, Hellström, Ann, Lund University.   +20 more
core   +1 more source

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze   +13 more
core   +2 more sources

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

IGF-1 changes over time.

, 2016
Linear annual change in IGF-1 levels of single individuals within groups of healthy controls (HC) and patients with Parkinson's disease in early (E-PD) or moderate (M-PD) disease stages.
Gerhard Binder (317355), Karin Weber (31717), Thomas Gasser (33499), Anja Apel (125870), Tanja Heger (728311), Susanne Nussbaum (2602867), Benjamin Roeben (3181527), Walter Maetzler (125849), Christian Deuschle (125867), Mirjam Maechtel (3181524), Felix P. Bernhard (3181521), Sebastian Heinzel (341355), Daniela Berg (125872)   +12 more
core   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

IGF-1 and IGF-1 SDS – fit for purpose? [PDF]

European Journal of Endocrinology, 2019
Kos, S., Cobbaert, C.M., Kuijper, T.M., Oostdijk, W., Hannema, S.E., Wit, J.M., Biermasz, N., Ballieux, B.E.P.B.   +7 more
openaire   +4 more sources