Results 81 to 90 of about 231,978 (311)

IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor?

Frontiers in Endocrinology, 2015
The role of Insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer.
Adam ePickard, Dennis J McCance, Dennis J McCance   +2 more
doaj   +1 more source

How IGF-1 activates its receptor [PDF]

Journal of Cell Communication and Signaling, 2015
This study presents a new model for IGF-I receptor activation in which the transmembrane domains are held apart until ligand binding brings them together in an activated state.
openaire   +2 more sources

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Study Protocol: insulin and its role in cancer [PDF]

, 2007
Background Studies have shown that metabolic syndrome and its consequent biochemical derangements in the various phases of diabetes may contribute to carcinogenesis. A part of this carcinogenic effect could be attributed to hyperinsulinism.
K Harish, M Dharmalingam, M Himanshu, I Wolf, A Czyzyk, AG Renehan, E Giovannucci, KE Anderson, I Wolf, M Pollak, S Lillioja, M Pollak, CA Conover, P Cohen, O Larsson, J-M Wifredo Ricart, C Camacho-Hubner, JM Holly, LC Giudice, DR Clemmons, JA Janssen, JK Cruickshank, American Diabetes Association, M Shirodkar, V Jayagopal, M Pollak, GD Smith, KE North, KS Polonsky   +28 more
core   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution

Neurotherapeutics
Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients’ brains.
Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann   +5 more
doaj   +1 more source

Serum N-Terminal Type III Procollagen Propeptide: An Indicator of Growth Hormone Excess and Response to Treatment in Feline Hypersomatotropism [PDF]

, 2016
BACKGROUND: N‐terminal type III procollagen propeptide (PIIINP) is a biomarker of soft tissue proliferation. Hypersomatotropism (HS) is associated with soft tissue proliferation.
Church, D B, Forcada, Y, Kenny, P J, Keyte, S V, Niessen, S J M   +4 more
core   +3 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities

Frontiers in Endocrinology
Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam, Noha M. Elemam, Hassan Youssef Hotait, Mohamed A. Saleh, Mohamed A. Saleh, Mohamed A. Saleh, Waseem El-Huneidi, Waseem El-Huneidi, Iman M. Talaat, Iman M. Talaat, Iman M. Talaat   +10 more
doaj   +1 more source