Results 71 to 80 of about 231,978 (311)

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani, Mario Passalacqua, Sara Maffioli, Lucia Briatore, Meriem Hamoudane, Paola Contini, Renzo Cordera, Davide Maggi   +7 more
doaj   +1 more source

Aging, IGF‐1, and diet

Aging Cell, 2009
Fontana et al. (2008) recently reported in Aging Cell their interesting findings, based on studies of 46 subjects, of the impact of chronic severe caloric restriction on insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) levels.
openaire   +2 more sources

Deficits in trabecular bone microarchitecture in young women with Type 1 diabetes mellitus [PDF]

, 2015
Context: The pathophysiological mechanism of increased fractures in young adults with Type 1 Diabetes Mellitus (T1DM) is unclear. Objective: Case:control study of trabecular bone microarchitecture and vertebral marrow adiposity in young women with ...
Al-Daghri, Almeida, Amiel, Baroncelli, Baxter, Benjamin, Bereket, Botolin, Bredella, Bredella, Brismar, Chamberlain, Dai, Dhaliwal, Donaldson, Dunger, Fazeli, Fazeli, Forsén, Genant, Gevers, Giustina, Goettsch, Govan, Guler, Hothersall, Issever, Justesen, Kawai, Li, Martin, McComb, Menagh, Miller, Naressi, Neumann, Nicodemus, Patsch, Qvist, Rosen, Santos, Schellinger, Shen, Slade, Svoren, Vanhamme, Vestergaard, Wagegg, Wędrychowicz, Zemel   +49 more
core   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Insulin-like growth factor-1/insulin-like growth factor-1 receptor signalling in macrophages facilitates recovery from acute lung injury

Annals of Medicine
Background No effective treatment strategy for acute respiratory distress syndrome (ARDS) has been established. Conflicting reports on the effects of insulin-like growth factor (IGF)-1 stimulation and the inhibition of IGF-1 receptor (IGF-1R) signalling ...
Miyuki Niisato, Masahiro Yamashita, Yasushi Kawasaki, Hiroshi Furukawa, Takashi Sato, Ichiro Kawada   +5 more
doaj   +1 more source

Serum Insulin-like Growth Factor-1 Is a Biomarker of Testosterone Production and Intact Acrosome in Asian Elephants (Elephas maximus)

Animals, 2022
The objective of this study was to find relationships among serum IGF-1, serum testosterone, seminal plasma IGF-1 concentrations and semen parameters in Asian elephants (Elephas maximus).
Yuqing Yang, Junpen Suwimonteerabutr, Taweepoke Angkawanish, Kaywalee Chatdarong   +3 more
doaj   +1 more source

Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. [PDF]

, 2016
UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of ...
Beardsall, Kathryn,, Dunger, David,, Hallberg, Boubou,, Hellström, Ann,, Hård, Anna-Lena,, Ley, David,, Lund University., Löfqvist, Chatarina,, Pupp, Ingrid,, Ramenghi, Luca A,, Smith, Lois E H,, van Marter, Linda,, van Weissenbruch, Mirjam,   +12 more
core   +3 more sources

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Insulin-like Growth Factor 1 in relation to future hearing impairment: findings from the English Longitudinal Study of Ageing. [PDF]

, 2017
Insulin-like Growth Factor 1 (IGF-1) is associated with cardiovascular disease, itself a risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for IGF-1 in hearing function. However, the link between IGF-1 and the
Batty, GD, Lassale, C, Steptoe, A, Zaninotto, P   +3 more
core   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source