Results 71 to 80 of about 29,874,260 (303)

IGF-binding protein 2 (IGFBP2) – oncogene or tumour suppressor?

Frontiers in Endocrinology, 2015
The role of Insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer.
Adam ePickard, Dennis J McCance, Dennis J McCance   +2 more
doaj   +1 more source

The Influence of Field‐Assisted Sintering Technology (FAST) Temperature and Cooling Rate on the Microstructural Evolution in Gamma‐Titanium Aluminide Alloy GE4822

Advanced Engineering Materials, EarlyView.
Controlling the Field Assisted Sintering Technology (FAST) parameters, dwell temperature and cooling rate, significantly influences the microstructural evolution in titanium aluminide GE4822. Significant γ‐lamellar colonies develop only upon cooling through the α‐transus.
Jack Krohn, James Pepper, Martin Jackson
wiley   +1 more source

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution

Neurotherapeutics
Little is known about the mechanisms that generate epileptic spasms following perinatal brain injury. Recent studies have implicated reduced levels of Insulin-like Growth Factor 1 (IGF-1) in these patients’ brains.
Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann   +5 more
doaj   +1 more source

Anabolic effects of IGF-1 signaling on the skeleton

Frontiers in Endocrinology, 2013
This review focuses on the anabolic effects of IGF-1 signaling on the skeleton, emphasizing the requirement for IGF-1 signaling in normal bone formation and remodeling.
Candice G. T Tahimic, Candice G. T Tahimic, Yongmei eWang, Yongmei eWang, Daniel D. Bikle, Daniel D. Bikle   +5 more
doaj   +1 more source

Fabrication Routes for Ionic Conducting Fiber Strain Sensors

Advanced Engineering Materials, EarlyView.
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw, Zhanhong Yang, Anne Ladegaard Skov, Magdalena Skowyra   +3 more
wiley   +1 more source

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway

Frontiers in Cellular Neuroscience
Insulin-like growth factor-1 (IGF-1) is a single chain polypeptide hormone that plays an essential role in intrauterine and postnatal growth. Recent studies suggest that IGF-1 and its receptor IGF-1R are involved in the pathogenesis of neurological ...
Yanli Tang, Rui Zhong, Jiayi Liang, Shuang Liu, Wanxia Liu, Tao Liu, Baohong Yuan, Baohong Yuan, Mengya Jiao, Mengya Jiao, Mengya Jiao, Hui Yin, Hui Yin   +12 more
doaj   +1 more source

Effect of the exercise on Insulin-like Growth Factor 1 ( IGF-1) in blood of rats exposed stress : compared among n-3, n-6, n-9 fatty acids [PDF]

, 2022
【目的】 IGF-1（Insulin-like Growth Factor 1）は脳の正常な成長やエイジングを維持している。しかし，老化とともにIGF-1が減少するので，認知機能低下の予防として運動が挙げられている。本研究では，ストレス負荷ラットに運動と脂質のn-9，n-3，n-6系脂肪酸摂取が血液中のIGF-1に及ぼす影響について比較検討を行うことを目的とした。 【方法】実験動物：Sprague-Dawley系雌ラットの4週齢を無作為にストレス負荷群とコントロール（ストレス負荷無し）群に分け ...
細井, 美那, 外西, 友里奈, 9000003762598, 中村, ひかる, サカイ, ケイコ, 今井, 琴蘭, 1206, 1205, 1204, 379, 宮脇, 理紗, 坂井, 恵子, 小坂, 歩未, 1209, 1208, 1207   +15 more
core  

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study

BMC Psychiatry, 2020
Background IGF-1 is an essential neurotrophin produced peripherally and in the brain. Impairments in the brain IGF-1 concentrations might be responsible for some aspects of major depressive disorder (MDD) pathogenesis, whereas peripheral IGF-1 could have
Oleg A. Levada, Alexandra S. Troyan, Irina Y. Pinchuk   +2 more
doaj   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source