Results 221 to 230 of about 29,874,260 (303)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Osteosarcopenia, Osteoporosis, and Sarcopenia in Liver Cirrhosis: Prevalence, Predictors, and Prognostic Significance of IGF-1 Deficiency. [PDF]

J Clin Med
Glamočanin T, Smiljić TV, Vukčević M, Savić Ž, Tamburić R, Bokan G, Kulić M, Lalović N, Lazendić N, Joksimović B, Djukić D, Prtina A, Nogo-Živanović D.   +12 more
europepmc   +1 more source

Basalt Fiber Surface Modification for Improved Interaction With Polyamide‐6 for High‐Performance Automotive Applications

Polymer Composites, EarlyView.
Amino‐silane treatment improves the basalt fiber–PA6 interface, enhancing composite performance. ABSTRACT Basalt fiber‐reinforced polymer (BFRP) composites have emerged as sustainable alternatives to glass fiber (GF) composites, but their performance is often controlled by the quality of the fiber–matrix adhesion.
Mohammad Mezbah Ul Hoque, Manuel Garcia‐Perez, Manuel Raul Pelaez‐Samaniego, Vikram Yadama   +3 more
wiley   +1 more source

A Potential Gut-Retina Axis in Retinopathy of Prematurity: Emerging Perspectives on Microbiome-Mediated Modulation of the IGF-1-VEGF Pathway. [PDF]

Int J Mol Sci
Shetty S, Luca R, Rodriguez SH, Skondra D.   +3 more
europepmc   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Young blood-induced rejuvenation of neurovascular coupling involves endothelial IGF-1/IGF-1R signaling: evidence from heterochronic parabiosis using endothelial IGF-1R deficient and systemic IGF-1 knockdown mice. [PDF]

Geroscience
Gulej R, Patai R, Chandragiri SS, Nagykaldi M, Brunner E, Mukli P, Nagy D, Kordestan KV, Ekambaram S, Shanmugarama S, Nagaraja RY, Yabluchanskiy A, Tarantini S, Csiszar A, Ungvari Z.   +14 more
europepmc   +1 more source

Molecular Interactions of Viral Insulin/IGF‐Like Peptides With Zebrafish Receptors

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Signaling through the insulin receptor (IR) and the type 1 insulin‐like growth factor receptor (IGF1R) is modulated by secreted hormones and growth factor ligands (e.g., insulin and insulin‐like growth factor 1, IGF1). Impaired signaling in these receptors often leads to diabetes and oncogenic diseases.
Lev Levintov, Harish Vashisth
wiley   +1 more source

Association of IGF-1 with hypertension among children and adolescents. [PDF]

BMC Pediatr
Zhao Z, Huang T, Xie P, Yue W, Zhang X, Fang Z, Cao Y, Liu Y.   +7 more
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source