Intranasal Administration of Insulin and IGF-1 Protects Hippocampal CA1 Neurons Against Transient Global Forebrain Ischemia by Inhibiting Autophagy, Apoptosis and Neuroinflammation: A Comparative Study. [PDF]
Int J Mol SciZakharova IO +3 more
europepmc +1 more source
Catechins and Their Effect on the Gut Microbiome in Health and Cancer
Phytotherapy Research, EarlyView.ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika +5 more
wiley +1 more source
The impact of genetic variants of the IGF-1 axis on surgical outcomes and prognosis in ovarian cancer. [PDF]
Mol Biol Repde Almeida Lopes I +5 more
europepmc +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
Placental hormones, IGF-1, and early-life growth: endocrine links between birth size and infant metabolic programming-a systematic review. [PDF]
Eur J PediatrSoliman AT +5 more
europepmc +1 more source
Stem Cell‐Based Approaches for Neurotrophic Keratopathy: From Ocular Surface to Neuro‐Ophthalmology
Sensory Neuroscience, EarlyView.ABSTRACT Neurotrophic keratopathy is an uncommon, but potentially sight‐threatening, corneal disorder that results from impaired trigeminal sensory innervation. The loss of corneal sensation disrupts epithelial stability, weakens wound healing, and may lead to persistent epithelial defects, stromal ulceration, and, in the most advanced cases, corneal ...
Matteo Capobianco, Marco Zeppieri
wiley +1 more source
Enhanced Expansion of Bone Marrow-Derived Mesenchymal Stem Cells on Collagen-Coated Microcarriers Functionalized with Chimeric IGF-1-bFGF Proteins. [PDF]
ACS OmegaPasanen S +5 more
europepmc +1 more source
Small, EarlyView.Bacterial viability is determined in a complex environment with a field‐effect biological transistor with a limit of detection of a single bacterium. Living, antibiotic‐treated, thermally denatured, and inhibited E. coli generate distinct electrical signatures, enabling label‐free single‐cell detection and providing new opportunities for rapid ...
Bar Chen +17 more
wiley +1 more source
Biomimetic bone scaffold functionalized with traditional Chinese medicine ingredients and collagen-binding IGF-1 for bone regeneration. [PDF]
J Mater Sci Mater MedGao X, Lei B, Zhao X, Zhang Y.
europepmc +1 more source
Small Methods, EarlyView.We developed a 3D‐printed nerve interface integrating a biomimetic nanocomposite hydrogel with sustained delivery of thermostable FGF‐2. The bioactive interface supports Schwann cell activity and myelination while providing a regenerative microenvironment.
Diego N. Rodriguez‐Sanchez +10 more
wiley +1 more source