Results 121 to 130 of about 101,358 (257)

Various phenotypes of short stature with heterozygous IGF-1 receptor (IGF1R) mutations. [PDF]

Clin Pediatr Endocrinol, 2022
Kawashima-Sonoyama Y, Hotsubo T, Hamajima T, Hamajima N, Fujimoto M, Namba N, Kanzaki S.   +6 more
europepmc   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Flow Cytometric Profiling Reveals Platelet Dysfunction and Impaired Immune Communication in Acute and Chronic Cerebrovascular Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Platelets act as sensors linking inflammation and neurovascular health. Flow cytometry revealed reduced PAC‐1 in acute/subacute ICH but elevated in chronic disease, while P‐selectin remained suppressed. T lymphocyte–platelet aggregates declined across groups, indicating disrupted immune crosstalk, and these biomarkers reflect stage‐specific platelet ...
Chih‐Lung Shen, Li‐Yu Huang, Jhong‐Kuei Chen, Sheng‐Tzung Tsai, Yi‐feng Wu   +4 more
wiley   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. [PDF]

EMBO Rep, 2021
Haywood NJ, Luk C, Bridge KI, Drozd M, Makava N, Skromna A, Maccannell A, Ozber CH, Warmke N, Wilkinson CG, Watt NT, Koch-Paszkowski J, Teh I, Boyle JH, Smart S, Schneider JE, Yuldasheva NY, Roberts LD, Beech DJ, Sukumar P, Wheatcroft SB, Cubbon RM, Kearney MT.   +22 more
europepmc   +1 more source

Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B.
Átila V. V. Nobre, Pedro H. F. Silva, Marina C. G. Del‐Arco, Raquel F. Gerlach, Rene S. Oliezer, José E. Tanus‐Santos, Luciene C. Figueiredo, Janaina S. A. M. Evangelista, Flávia A. C. Furlaneto, Michel R. Messora, Sérgio Luiz Salvador   +10 more
wiley   +1 more source

A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor. [PDF]

Mol Metab, 2021
Zhang F, Altindis E, Kahn CR, DiMarchi RD, Gelfanov V.   +4 more
europepmc   +1 more source

Crystal Structure of Bisphosphorylated IGF-1 Receptor Kinase [PDF]

Structure, 2001
Pautsch, Alexander, Zoephel, Andreas, Ahorn, Horst, Spevak, Walter, Hauptmann, Rudolf, Nar, Herbert   +5 more
openaire   +1 more source

Metabolic and hormonal serum markers in early childhood: Follow‐up of a randomized controlled trial during infancy evaluating a modified, low‐protein infant formula

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives High protein intake during infancy has been linked to accelerated weight gain and increased obesity risk. This study aimed to examine the effects of a low‐protein formula during the first 6 months of life on blood metabolic and hormonal markers during early childhood. Methods Formula‐fed infants (<45 days) were randomized to receive
Jacqueline Muts, Stefanie M. P. Kouwenhoven, Nadja Antl, Marieke Abrahamse‐Berkeveld, Britt J. van Keulen, Hans Demmelmair, Lesca M. Holdt, Wolfgang Wilfert, Chris H. P. van den Akker, Johannes B. van Goudoever, Berthold Koletzko   +10 more
wiley   +1 more source

DAF-2/insulin IGF-1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues. [PDF]

Aging Cell, 2022
Roy C, Molin L, Alcolei A, Solyga M, Bonneau B, Vachon C, Bessereau JL, Solari F.   +7 more
europepmc   +1 more source