Results 171 to 180 of about 30,609,190 (316)

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. [PDF]

Growth Horm IGF Res, 2022
Osganian SA, Subudhi S, Masia R, Drescher HK, Bartsch LM, Chicote ML, Chung RT, Gee DW, Witkowski ER, Bredella MA, Lauer GM, Corey KE, Dichtel LE.   +12 more
europepmc   +1 more source

Under‐Explored Species, Breeds and Cell Types With Potential for Cultivated Meat Production

Food Bioengineering, EarlyView.
This graphical abstract illustrates how the strategic selection of overlooked cell lines from novel species and specific agricultural breeds can help overcome current manufacturing bottlenecks in cultivated meat production. The schematic links the concept of an ‘ideal cell line’ to four key bioprocessing and product advantages that can be optimised ...
William Gordon‐Petrovskii, Maanasa Ravikumar, Travis Callue, Maria Laura Vieri, Michael Sulu, Gary J. Lye, Mariana Petronela Hanga   +6 more
wiley   +1 more source

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health

JCI Insight
Insulin/insulin growth factor signaling is a conserved pathway that regulates lifespan. However, long-lived loss-of-function mutants often produce insulin resistance, slow growth, and impair reproduction.
Ulalume Hernández-Arciga, Jun Kyoung Kim, Jacob L. Fisher, Alexander Tyshkovskiy, Alibek Moldakozhayev, Catherine Hall, Souvik Ghosh, Yashvandhini Govindaraj, Ian J. Sipula, Jake Kastroll, Diana Cooke, Jinping Luo, Jonathan K. Alder, Stacey J. Sukoff Rizzo, Gene P. Ables, Eunhee Choi, Vadim N. Gladyshev, Michael J. Jurczak, Marc Tatar, Andrey A. Parkhitko   +19 more
doaj   +1 more source

Various phenotypes of short stature with heterozygous IGF-1 receptor (IGF1R) mutations. [PDF]

Clin Pediatr Endocrinol, 2022
Kawashima-Sonoyama Y, Hotsubo T, Hamajima T, Hamajima N, Fujimoto M, Namba N, Kanzaki S.   +6 more
europepmc   +1 more source

Immunomodulatory Effect of Tilapia (Oreochromis niloticus) Scale Gelatin Peptides in RAW264.7 Macrophages and Caenorhabditis elegans

Food Safety and Health, EarlyView.
ABSTRACT Currently, small‐molecular‐weight collagen peptides are a research hotspot in functional factor development due to their high bioavailability and diverse bioactivities. In this study, gelatin was extracted from tilapia (Oreochromis niloticus) scales by hot water extraction, followed by pepsin hydrolysis and ultrafiltration to obtain the < 3 ...
Ya‐ru Liu, Xu Guo, Shu‐tao Sun, Rui‐rui Zhang, Chao Liu, Ning‐yang Li   +5 more
wiley   +1 more source

IGF-1R : studies on the expression and role in transformation

, 2009
Transformation is a complex nonlinear multistep process during which normal cell becomes cancerous. Main characteristics of transformed cells include uncontrolled growth, invasion and metastasis.
Natalia Natalishvili (19525831)
core   +1 more source

Supplementary material to Conjoining of the TSH Receptor With the IGF-1 Receptor With Particular Attention to the Role of β1-arrestin. DOI:10.1210/endocr/bqaf191

Mihaly Mezei, Rauf Latif, Terry F. Davies   +2 more
openalex   +2 more sources

New‐Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank

International Journal of Cancer, EarlyView.
ABSTRACT The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly in China and is linked to increased cancer risk, but causality remains unclear due to biases. We examined the causal effect of T2DM on cancer risk using bias‐minimizing methods.
Mengying Wang, Owen Tipping, Bowen Liu, Derrick A. Bennett, Baiyong Shen, Siyi Zou, Shulin Zhao, Richard M. Martin, Matthew Sperrin, Andrew G. Renehan   +9 more
wiley   +1 more source