Results 191 to 200 of about 30,609,190 (316)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Defective IGF-1 prohormone N-glycosylation and reduced IGF-1 receptor signaling activation in congenital disorders of glycosylation. [PDF]

Cell Mol Life Sci, 2022
Di Patria L, Annibalini G, Morrone A, Ferri L, Saltarelli R, Galluzzi L, Diotallevi A, Bocconcelli M, Donati MA, Barone R, Guerrini R, Jaeken J, Stocchi V, Barbieri E.   +13 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex. [PDF]

Theranostics, 2022
Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C.   +5 more
europepmc   +1 more source

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

Interdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim, Eun‐Kyung Min, Choon‐Mi Lee, Kun‐Hee Na, Chan Hum Park, YunJae Jung, Hwa‐Yong Lee   +6 more
wiley   +1 more source

Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells. [PDF]

Sci Rep, 2022
Jiménez-Castillo V, Illescas-Barbosa D, Zenteno E, Ávila-Curiel BX, Castañeda-Patlán MC, Robles-Flores M, De Oca DM, Pérez-Campos E, Torres-Rivera A, Bouaboud A, Pagesy P, Solórzano-Mata CJ, Issad T.   +12 more
europepmc   +1 more source

First‐Trimester Crown‐Rump Length and Large for Gestational Age Newborns: What Correlation?

Journal of Clinical Ultrasound, EarlyView.
Our research found for the first time that uneventful pregnancies with LGA neonates are characterized by larger than expected CRL at the first trimester. CRL is one of the new markers that can be used to early identify fetuses at risk of increased fetal growth.
Marika Ylenia Rovetto, Laura Sarno, Giuseppe Gabriele Iorio, Giuliana Orlandi, Caterina Fulgione, Mariarosaria Motta, Anna Luna Tramontano, Giuseppe Rizzo, Ilenia Mappa, Maurizio Guida, Giuseppe Maria Maruotti   +10 more
wiley   +1 more source

Maternal Diabetes Impairs Insulin and IGF-1 Receptor Expression and Signaling in Human Placenta. [PDF]

Front Endocrinol (Lausanne), 2021
Tumminia A, Scalisi NM, Milluzzo A, Ettore G, Vigneri R, Sciacca L.   +5 more
europepmc   +1 more source

Thyroid eye disease: revolutionizing treatment with IGF-1 receptor targeted therapy [PDF]

Thomas A. Ciulla, Shoaib Ugradar, Terry J. Smith   +2 more
openalex   +1 more source

The effect of leukocyte–platelet‐rich fibrin in periodontal surgery on clinical parameters and patient‐related outcome measures: A randomized, controlled, clinical study

Journal of Periodontology, EarlyView.
Abstract Background This prospective study aimed to assess the clinical outcomes and patient‐related outcome measures (PROMs) of open flap debridement (OFD) alone versus open flap debridement with leukocyte–platelet‐rich fibrin (L‐PRF). Methods Twenty‐one patients were enrolled into a split‐mouth randomized clinical trial.
Jackson S. Sides, Archontia Palaiologou, Brian L. Mealey, Stephan J. Haney, Kerri Font, Charles A. Powell   +5 more
wiley   +1 more source