Results 211 to 220 of about 101,358 (257)

Decision letter: How IGF-1 activates its receptor

, 2014
openaire   +1 more source

Beyond the Wheeze: Incidental Diagnosis of Eosinophilic Oesophagitis in a Young Child With Asthma‐Like Symptoms

Journal of Paediatrics and Child Health, EarlyView.
Sameena Tabassum, Keslar Just, Mili Jyotsna, Anayansi Lasso‐Pirot   +3 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

The IGF‐1 receptor in cancer biology

International Journal of Cancer, 2003
AbstractThe type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF‐1R leads to massive apoptosis of cancer cells.
Renato, Baserga, Francesca, Peruzzi, Krysztof, Reiss   +2 more
openaire   +2 more sources

Leukocyte IGF-1 Receptor Expression during Muscle Recovery

Medicine & Science in Sports & Exercise, 2015
The insulin-like growth factor 1 (IGF-1) system plays a central role in anabolic cellular processes. Recently, a regulatory role of IGF-1 in the immune response for muscle repair has been suggested, but how it modulates the inflammatory process is largely unknown.
Maren S, Fragala, Adam R, Jajtner, Jeremy R, Townsend, Adam M, Gonzalez, Adam J, Wells, Leonardo P, Oliveira, Jay R, Hoffman, Jeffrey R, Stout, David H, Fukuda   +8 more
openaire   +3 more sources

IGF-1 receptor inhibition by picropodophyllin in medulloblastoma

Biochemical and Biophysical Research Communications, 2010
The insulin-like growth factor-1 receptor (Igf1r) is a multifunctional membrane-associated tyrosine kinase associated with regulation of transformation, proliferation, differentiation and apoptosis. Increased IGF pathway activity has been reported in human and murine medulloblastoma.
Sachiko, Ohshima-Hosoyama, Tohru, Hosoyama, Laura D, Nelon, Charles, Keller   +3 more
openaire   +2 more sources

Substrate Competitive Inhibitors of IGF-1 Receptor Kinase

Biochemistry, 2000
IGF-1 and its receptor play a pivotal role in many cancers, and therefore, IGF-1R is an attractive target for the design of inhibitors. In this communication, we report on a number of lead compounds for inhibitors of the isolated IGF-1R kinase. The search for these compounds utilized two novel in vitro assays and was aided by the knowledge of the three-
G, Blum, A, Gazit, A, Levitzki
openaire   +2 more sources

Identification of IGF-1 receptors in primitive vertebrates

Regulatory Peptides, 1993
This is the first report of the existence of insulin-like growth factor (IGF-1) receptors in three representatives of lower vertebrates: the osteichtyes, chondrichtyes and cyclostomi. Competitive binding studies and affinity labelling of brain membranes from Cottus scorpius (sea scorpion), Raja clavata (ray) and Myxine glutinosa (atlantic hagfish ...
K, Drakenberg, V R, Sara, S, Falkmer, S, Gammeltoft, C, Maake, M, Reinecke   +5 more
openaire   +2 more sources

Molecular IGF-1 and IGF-1 Receptor Defects: From Genetics to Clinical Management

2013
Molecular defects of the insulin-like growth factor 1 gene (IGF1) are rare in the human. Only three homozygous and two families with heterozygous mutations of the IGF1 gene have been described, resulting in a variable degree of intrauterine and postnatal growth retardation, microcephaly, developmental delay and deafness.
Walenkamp, M.J.E., Losekoot, M., Wit, J.M.   +2 more
openaire   +4 more sources

S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1

Biochemical and Biophysical Research Communications, 2017
The insulin-like growth factor 1 receptor (IGF-1R) is a disulfide-linked heterotetramer containing two α-subunits and two β-subunits. Earlier studies demonstrate that nitric oxide (NO) can adversely affect IGF-1 action in the central nervous system.
Kazushi, Okada, Bao-Ting, Zhu
openaire   +2 more sources