Results 261 to 270 of about 30,609,190 (316)

NA-931, a novel quadruple IGF-1, GLP-1 and GIP incretin receptor agonist reduces body weight without muscle loss

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The IGF‐1 receptor in cancer biology

International Journal of Cancer, 2003
AbstractThe type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF‐1R leads to massive apoptosis of cancer cells.
Renato, Baserga, Francesca, Peruzzi, Krysztof, Reiss   +2 more
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Identification of IGF-1 receptors in primitive vertebrates

Regulatory Peptides, 1993
This is the first report of the existence of insulin-like growth factor (IGF-1) receptors in three representatives of lower vertebrates: the osteichtyes, chondrichtyes and cyclostomi. Competitive binding studies and affinity labelling of brain membranes from Cottus scorpius (sea scorpion), Raja clavata (ray) and Myxine glutinosa (atlantic hagfish ...
K, Drakenberg, V R, Sara, S, Falkmer, S, Gammeltoft, C, Maake, M, Reinecke   +5 more
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Molecular IGF-1 and IGF-1 Receptor Defects: From Genetics to Clinical Management

2013
Molecular defects of the insulin-like growth factor 1 gene (IGF1) are rare in the human. Only three homozygous and two families with heterozygous mutations of the IGF1 gene have been described, resulting in a variable degree of intrauterine and postnatal growth retardation, microcephaly, developmental delay and deafness.
Walenkamp, M.J.E., Losekoot, M., Wit, J.M.   +2 more
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IGF-1 receptor inhibition by picropodophyllin in medulloblastoma

Biochemical and Biophysical Research Communications, 2010
The insulin-like growth factor-1 receptor (Igf1r) is a multifunctional membrane-associated tyrosine kinase associated with regulation of transformation, proliferation, differentiation and apoptosis. Increased IGF pathway activity has been reported in human and murine medulloblastoma.
Sachiko, Ohshima-Hosoyama, Tohru, Hosoyama, Laura D, Nelon, Charles, Keller   +3 more
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Customizing The Targeting of IGF-1 Receptor

Future Oncology, 2009
The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.
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S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1

Biochemical and Biophysical Research Communications, 2017
The insulin-like growth factor 1 receptor (IGF-1R) is a disulfide-linked heterotetramer containing two α-subunits and two β-subunits. Earlier studies demonstrate that nitric oxide (NO) can adversely affect IGF-1 action in the central nervous system.
Kazushi, Okada, Bao-Ting, Zhu
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Insulin receptor structure and its implications for the IGF-1 receptor

Current Opinion in Structural Biology, 2007
The insulin receptor (isoforms IR-A and IR-B) and the type-I insulin-like growth factor receptor (IGF-1R) are homologous, multi-domain tyrosine kinases that bind insulin and IGF-1 with differing specificity. IR is involved in metabolic regulation and IGF-1R in normal growth and development.
Michael C, Lawrence, Neil M, McKern, Colin W, Ward   +2 more
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Effect of IGF-1 injection on the expression of GM receptor, IGF-1, IGF-1 receptor, KAP3.2 and KAP6-1 mRNA in the skin of sheep

Animal Production Research Advances, 2009
No Abstract.Animal Production Research Advances Vol. 4 (2) 2008: pp.
CHengxian, Z, Herong, L, Yan, Z
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