Results 1 to 10 of about 19,264 (196)

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells [PDF]

Frontiers in Immunology
BackgroundThe insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic treatment
Maximilian Luffy, Anna-Lena Ganz, Stefanie Wagner, Jan Wolf, Julian Ropertz, Ryan Zeidan, Jeffrey D. Kent, Raymond S. Douglas, George J. Kahaly   +8 more
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Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications [PDF]

International Journal of Women's Health
Junyou Su,1,* Xiaoting Huang,1,* Shengping Meng,2 Sumei Wang2 1Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China; 2Department of Obstetrics, The First ...
Su J, Huang X, Meng S, Wang S
doaj   +2 more sources

The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells [PDF]

Cell Communication and Signaling, 2023
Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenografts ...
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu   +7 more
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Detection of Genome‐Wide IGF‐1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers [PDF]

Cancer Medicine
Introduction Nuclear insulin‐like growth factor‐1 receptor (IGF‐1R) undergoes IGF‐induced recruitment to cancer cell chromatin in vitro and associates with advanced prostate cancer (PCa) stage in clinical tissue, prompting this investigation of IGF‐1R ...
Jack V. Mills, Avigail Taylor, Reema Singh, Jinseon Kim, Simon Engledow, Richard Colling, Clare Verrill, Ian G. Mills, Valentine M. Macaulay   +8 more
doaj   +2 more sources

IGF-1R targeting in cancer – does sub-cellular localization matter? [PDF]

Journal of Experimental & Clinical Cancer Research, 2023
The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued kinase targets in oncology. However, even after a slew of small-molecule and antibody therapeutics reached clinical trials for a range of solid tumors, the initial ...
Upendra K. Soni, Liam Jenny, Rashmi S. Hegde   +2 more
doaj   +2 more sources

IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway [PDF]

Scientific Reports
Myofascial pain syndrome (MPS) is a common chronic pain condition characterized primarily by the presence of myofascial trigger points (MTrPs). While the insulin-like growth factor-1 receptor (IGF-1R) is known to be upregulated in injured muscles and ...
Lingwei Zhou, Miao Pei, Tian Qi, Yu Liu, Xiaoyue Li, Xuan Li, Qinghe Chen, Feihong Jin, Shaozhong Yang, Feng Qi   +9 more
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IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis [PDF]

Journal of Experimental & Clinical Cancer Research
Background Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some of NPC patients have bone metastases at the time of initial diagnosis.
Kaifan Yang, Yanjun Hu, Yuanyuan Feng, Kaiqun Li, Ziyan Zhu, Shuyi Liu, Yanling Lin, Bin Yu   +7 more
doaj   +2 more sources

Preclinical Evaluation of a New Format of ⁶⁸Ga- and ¹¹¹In-Labeled Affibody Molecule Z_IGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Pharmaceutics, 2022
The Insulin-like growth factor-1 receptor (IGF-1R) is a molecular target for several monoclonal antibodies undergoing clinical evaluation as anticancer therapeutics. The non-invasive detection of IGF-1R expression in tumors might enable stratification of
Yongsheng Liu, Shengze Yu, Tianqi Xu, Vitalina Bodenko, Anna Orlova, Maryam Oroujeni, Sara S. Rinne, Vladimir Tolmachev, Anzhelika Vorobyeva, Torbjörn Gräslund   +9 more
doaj   +1 more source

Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. [PDF]

PLoS ONE, 2012
Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ.
Neil Hoa, Shanli Tsui, Nikoo F Afifiyan, Amiya Sinha Hikim, Bin Li, Raymond S Douglas, Terry J Smith   +6 more
doaj   +1 more source

Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets

Frontiers in Oncology, 2021
AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang, Yinqi Zhang, Chengqi Gao, Fei Cao, Fei Cao, Ying Wu, Ying Wu, Shuanggang Chen, Xue Han, Xue Han, Jingqin Mo, Zhiyu Qiu, Zhiyu Qiu, Weijun Fan, Weijun Fan, Penghui Zhou, Lujun Shen, Lujun Shen   +17 more
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