Results 1 to 10 of about 17,503 (136)
Lactoferrin Induces Osteoblast Growth through IGF-1R [PDF]
International Journal of Endocrinology, 2015 Objectives. To investigate the role of the IGF-1R by which lactoferrin induces osteoblast growth. Methods. Osteoblast received 5 d lactoferrin intervention at a concentration of 0.1, 1, 10, 100, and 1000 μg/mL, and the IGF-1 and IGF-1R were detected ...
Jian-Ming Hou +6 more
doaj +3 more sources
Molecular Imaging of IGF-1R in Cancer [PDF]
Molecular Imaging, 2017 The important role of insulin-like growth factor 1 receptor (IGF-1R) in malignant tumors has been well established. Increased IGF-1R activity promotes cancer cell proliferation, migration, and invasion and is associated with tumor metastasis, treatment ...
Yingying Sun PhD +2 more
doaj +3 more sources
Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications [PDF]
International Journal of Women's HealthJunyou Su,1,* Xiaoting Huang,1,* Shengping Meng,2 Sumei Wang2 1Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China; 2Department of Obstetrics, The First ...
Su J, Huang X, Meng S, Wang S
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Detection of Genome‐Wide IGF‐1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers [PDF]
Cancer MedicineIntroduction Nuclear insulin‐like growth factor‐1 receptor (IGF‐1R) undergoes IGF‐induced recruitment to cancer cell chromatin in vitro and associates with advanced prostate cancer (PCa) stage in clinical tissue, prompting this investigation of IGF‐1R ...
Jack V. Mills +8 more
doaj +2 more sources
The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells [PDF]
Cell Communication and Signaling, 2023 Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenografts ...
Yu-Tzu Chan +7 more
doaj +2 more sources
β<sub>1</sub>-integrin controls IGF-1R internalization and intracellular signaling. [PDF]
J Biol ChemCell adhesion-dependent phosphorylation of insulin-like growth factor 1 receptor (IGF-1R) on its C-terminal tail (CT) at Tyr1250/1251 promotes receptor internalization and Golgi accumulation. We previously proposed that this phosphorylation is associated with cell migration and cancer aggressiveness, distinguishing IGF-1R activity from that of insulin ...
McDermott N +4 more
europepmc +3 more sources
IGF-1R targeting in cancer – does sub-cellular localization matter? [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued kinase targets in oncology. However, even after a slew of small-molecule and antibody therapeutics reached clinical trials for a range of solid tumors, the initial ...
Upendra K. Soni +2 more
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Drugging IGF-1R in cancer: New insights and emerging opportunities
Genes and Diseases, 2023 The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages.
Panpan Wang +2 more
doaj +3 more sources
IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway [PDF]
Scientific ReportsMyofascial pain syndrome (MPS) is a common chronic pain condition characterized primarily by the presence of myofascial trigger points (MTrPs). While the insulin-like growth factor-1 receptor (IGF-1R) is known to be upregulated in injured muscles and ...
Lingwei Zhou +9 more
doaj +2 more sources
GIGYF1 disruption associates with autism and impaired IGF-1R signaling. [PDF]
J Clin Invest, 2022 Autism spectrum disorder (ASD) represents a group of neurodevelopmental phenotypes with a strong genetic component. An excess of likely gene-disruptive (LGD) mutations in GIGYF1 was implicated in ASD. Here, we report that GIGYF1 is the second-most mutated gene among known ASD high-confidence risk genes.
Chen G +33 more
europepmc +4 more sources