Results 11 to 20 of about 19,264 (196)
Haematologica, 2010 Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy.
Nicolas Chapuis +12 more
doaj +3 more sources
Lactoferrin Induces Osteoblast Growth through IGF-1R [PDF]
International Journal of Endocrinology, 2015 Objectives. To investigate the role of the IGF-1R by which lactoferrin induces osteoblast growth. Methods. Osteoblast received 5 d lactoferrin intervention at a concentration of 0.1, 1, 10, 100, and 1000 μg/mL, and the IGF-1 and IGF-1R were detected ...
Jian-Ming Hou +6 more
doaj +3 more sources
IGF-1R as an anti-cancer target--trials and tribulations [PDF]
Chinese Journal of Cancer, 2013 Type I insulin-like growth factor receptor (IGF-1R) has long been recognized for its role in tumorigenesis and growth, but only recently have the tools for targeting the IGF pathway become available. More than 10 IGF/IGF-1R inhibitors have entered clinical trials, and these belong to three main classes: (1) monoclonal antibodies against IGF-1R, (2 ...
Chen, Helen X., Sharon, Elad
openaire +4 more sources
Molecular Imaging of IGF-1R in Cancer [PDF]
Molecular Imaging, 2017 The important role of insulin-like growth factor 1 receptor (IGF-1R) in malignant tumors has been well established. Increased IGF-1R activity promotes cancer cell proliferation, migration, and invasion and is associated with tumor metastasis, treatment ...
Yingying Sun PhD +2 more
doaj +3 more sources
Drugging IGF-1R in cancer: New insights and emerging opportunities
Genes and Diseases, 2023 The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages.
Panpan Wang +2 more
doaj +3 more sources
A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R): Implications for Inhibition of the IGF-1R signal [PDF]
Oncotarget, 2013 It has been demonstrated that epidermal growth factor receptor (EGFR) can have kinase independent activity. EGFR kinase-independent function maintains intracellular glucose levels via sodium glucose transporter protein 1 (SGLT1) and supports cell survival. It is plausible that this phenomenon can apply to other receptor tyrosine kinases.
Janku, Filip +3 more
openaire +6 more sources
Disorders of IGFs and IGF-1R signaling pathways
Molecular and Cellular Endocrinology, 2020 The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth.
Forbes, B.E., Blyth, A.J., Wit, J.M.
openaire +5 more sources
Anti-IGF-1R Recombinant Monoclonal Antibody BIIB022 [PDF]
, 2020 National Cancer Institute
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β<sub>1</sub>-integrin controls IGF-1R internalization and intracellular signaling. [PDF]
J Biol ChemCell adhesion-dependent phosphorylation of insulin-like growth factor 1 receptor (IGF-1R) on its C-terminal tail (CT) at Tyr1250/1251 promotes receptor internalization and Golgi accumulation. We previously proposed that this phosphorylation is associated with cell migration and cancer aggressiveness, distinguishing IGF-1R activity from that of insulin ...
McDermott N +4 more
europepmc +3 more sources
CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway [PDF]
Cells, 2020 Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal.
Chih-Lun Cheng +11 more
openaire +3 more sources