Results 11 to 20 of about 17,525 (157)

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells [PDF]

Frontiers in Immunology
BackgroundThe insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic treatment
Maximilian Luffy, Anna-Lena Ganz, Stefanie Wagner, Jan Wolf, Julian Ropertz, Ryan Zeidan, Jeffrey D. Kent, Raymond S. Douglas, George J. Kahaly   +8 more
doaj   +2 more sources

Progerin modulates the IGF-1R/Akt signaling involved in aging. [PDF]

Sci Adv, 2022
Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disorder. Progerin also accumulates during physiological aging.
Jiang B, Wu X, Meng F, Si L, Cao S, Dong Y, Sun H, Lv M, Xu H, Bai N, Guo Q, Song X, Yu Y, Guo W, Yi F, Zhou T, Li X, Feng Y, Wang Z, Zhang D, Guan Y, Ma M, Liu J, Li X, Zhao W, Liu B, Finkel T, Cao L.   +27 more
europepmc   +3 more sources

OR31-06 Lonigutamab (Anti-IGF-1R Monoclonal Antibody) Induces Efficient Degradation of IGF-1R in Thyroid Eye Disease Orbital Fibroblasts [PDF]

J Endocr Soc
Abstract Disclosure: B. Welch: ACELYRIN, INC. E. Roztocil: National Institutes of Health, National Eye Institute, ValenzaBio, Inc./ACELYRIN, INC. F. Husain: National Institutes of Health, National Eye Institute, ValenzaBio, Inc./ACELYRIN, INC. S.E.
Welch, Brett, Roztocil, Elisa, Husain, Farha, Feldon, Steven E, Nyborg, Andrew, Mpofu, Shephard, Woeller, Collynn F   +6 more
europepmc   +2 more sources

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis [PDF]

Journal of Experimental & Clinical Cancer Research
Background Nasopharyngeal carcinoma (NPC) poses a significant health burden in specific regions of Asia, and some of NPC patients have bone metastases at the time of initial diagnosis.
Kaifan Yang, Yanjun Hu, Yuanyuan Feng, Kaiqun Li, Ziyan Zhu, Shuyi Liu, Yanling Lin, Bin Yu   +7 more
doaj   +2 more sources

Preclinical Evaluation of a New Format of ⁶⁸Ga- and ¹¹¹In-Labeled Affibody Molecule Z_IGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Pharmaceutics, 2022
The Insulin-like growth factor-1 receptor (IGF-1R) is a molecular target for several monoclonal antibodies undergoing clinical evaluation as anticancer therapeutics. The non-invasive detection of IGF-1R expression in tumors might enable stratification of
Yongsheng Liu, Shengze Yu, Tianqi Xu, Vitalina Bodenko, Anna Orlova, Maryam Oroujeni, Sara S. Rinne, Vladimir Tolmachev, Anzhelika Vorobyeva, Torbjörn Gräslund   +9 more
doaj   +1 more source

CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway [PDF]

Cells, 2020
Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal.
Chih-Lun Cheng, Shang-Chih Yang, Chien-Ying Lai, Cheng-Kai Wang, Ching-Fang Chang, Chun-Yu Lin, Wei-Ju Chen, Po-Yu Lin, Han-Chung Wu, Nianhan Ma, Frank Leigh Lu, Jean Lu   +11 more
openaire   +3 more sources

Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. [PDF]

PLoS ONE, 2012
Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ.
Neil Hoa, Shanli Tsui, Nikoo F Afifiyan, Amiya Sinha Hikim, Bin Li, Raymond S Douglas, Terry J Smith   +6 more
doaj   +1 more source

Allosteric IGF-1R Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2010
Targeting allosteric protein sites is a promising approach to interfere selectively with cellular signaling cascades. We have discovered a novel class of allosteric insulin-like growth factor-I receptor (IGF-1R) inhibitors. 3-Cyano-1H-indole-7-carboxylic acid {1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}amide (10) was found with nanomolar ...
Timo, Heinrich, Ulrich, Grädler, Henning, Böttcher, Andree, Blaukat, Adam, Shutes   +4 more
openaire   +2 more sources

Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. [PDF]

PLoS ONE, 2012
BACKGROUND: Insulin-like growth factors (IGF-I and -II) are pleiotropic regulators of somatic growth and development in vertebrate species. Endocrine and paracrine effects of both hormones are mediated by a common IGF type 1 receptor (IGF-1R).
Ralph Epaud, Flore Aubey, Jie Xu, Zayna Chaker, Maud Clemessy, Alexandre Dautin, Karmène Ahamed, Monique Bonora, Nadia Hoyeau, Jean-François Fléjou, Arnaud Mailleux, Annick Clement, Alexandra Henrion-Caude, Martin Holzenberger   +13 more
doaj   +1 more source

Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets

Frontiers in Oncology, 2021
AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang, Yinqi Zhang, Chengqi Gao, Fei Cao, Fei Cao, Ying Wu, Ying Wu, Shuanggang Chen, Xue Han, Xue Han, Jingqin Mo, Zhiyu Qiu, Zhiyu Qiu, Weijun Fan, Weijun Fan, Penghui Zhou, Lujun Shen, Lujun Shen   +17 more
doaj   +1 more source