Results 21 to 30 of about 17,525 (157)
Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
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Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells. [PDF]
PLoS ONE, 2012 Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R).
Yu-Chieh Wu +2 more
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Frontiers in Endocrinology, 2021 Ligand-induced activation of the IGF-1 receptor triggers plasma-membrane-derived signal transduction but also triggers receptor endocytosis, which was previously thought to limit signaling.
Leonie Rieger, Rosemary O’Connor
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Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. [PDF]
PLoS ONE, 2014 The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases.
Zheng Liang +6 more
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Endothelium–gut communication: IGF‐1Rs crosstalk with microbiota
EMBO reports, 2021 The gut, with its extensive microbiota, plays a fundamental role in metabolism. While alterations of the gut microbiota can induce dysfunction of the endothelium, it remains unclear whether the endothelium can directly impact the gut microbiota. To answer this question, in this issue of EMBO Reports Haywood and colleagues deployed a murine model with ...
Zhen Bouman Chen, Naseeb Kaur Malhi
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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Cell Death and Disease, 2022 Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala +6 more
doaj +1 more source
Deficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblasts. [PDF]
PLoS ONE, 2013 IGF-1 receptor (IGF-1R) signaling regulates cell growth, transformation and survival. Haploinsufficiency of the IGF-1R is reported to paradoxically confer resistance to oxidative stress in vivo and in cells cultured from Igf1r(+/-) mice.
Sachin Thakur, Neha Garg, Martin L Adamo
doaj +1 more source
Respiratory Research, 2005 Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François +7 more
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The Role of IGF-1R in Pediatric Malignancies [PDF]
The Oncologist, 2009 Learning Objectives Evaluate the components that make up the insulin-like growth factor family. Differentiate between different strategies to modulate IGF-1R. Determine when to utilize the rationale for therapeutic targeting of IGF-1R in childhood malignancies.
Su Young, Kim +3 more
openaire +2 more sources
Haematologica, 2010 Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy.
Nicolas Chapuis +12 more
doaj +1 more source