Results 101 to 110 of about 14,093,235 (401)

Growth Hormone and Insulin-Like Growth Factor-I alter Hippocampal Excitatory Synaptic Transmission in Young and Old Rats [PDF]

, 2013
Cataloged from PDF version of article.In rats, as in humans, normal aging is characterized by a decline in hippocampal-dependent learning and memory, as well as in glutamatergic function.
Adams, M. M., Ariwodola, O. J., Brunso Bechtold, J. K., Molina, D. P., Weiner, J. L.   +4 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I

Journal of Cell Biology, 1993
Insulin-like growth factor binding proteins (IGFBPs) have been shown to serve as carrier proteins for the insulin-like growth factors (IGFs) and to modulate their biologic effects. Since extracellular matrix (ECM) has been shown to be a reservoir for IGF-
J. I. Jones, Amy Gockerman, W. Busby, C. Camacho‐Hübner, D. Clemmons   +4 more
semanticscholar   +1 more source

IGF-I signalling in bone growth:inhibitory actions of dexamethasone and IL-1beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Ahmed, S.F., Ahmed, S.F., Farquharson, C., Macrae, V.E., Mushtaq, T.   +4 more
core   +1 more source

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner

Neurobiology of Disease, 2003
The effects of insulin-like growth factor-I (IGF-I) on cerebellar dysfunction and neurodegeneration were investigated in leaner mice, which exhibit cerebellar ataxia and neurodegeneration related to P/Q-type calcium channel mutations.
Sang-Soep Nahm, Tamy C Frank, Michelle D Browning, Jarita M Sepulvado, Jill K Hiney, Louise C Abbott   +5 more
doaj   +1 more source

Insulin-like growth factor I (IGF-I) in a growth-enhanced transgenic (GH-overexpressing) bony fish, the tilapia ( Oreochromis niloticus ): indication for a higher impact of autocrine/paracrine than of endocrine IGF-I [PDF]

, 2018
Several lines of growth hormone (GH)-overexpressing fish have been produced and analysed for growth and fertility parameters. However, only few data are available on the growth-promoting hormone insulin-like growth factor I (IGF-I) that mediates most ...
Caelers, Antje, Eppler, Elisabeth, Hwang, Guylin, Maclean, Norman, Rahman, Azizur, Reinecke, Manfred, Shved, Natallia, Zapf, Jürgen   +7 more
core  

Untersuchung zur IGF-I-vermittelten Signaltransduktion in der humanen Karzinoidzellinie LCC-18 [PDF]

, 2004
In dieser Arbeit wurde die Wachstumsregulation der Zellinie LCC-18 durch IGF-I untersucht. Die Zellinie LCC-18 wurde aus einem humanen Kolon-Karzinoid etabliert und zeigte stabile neuroendokrine Eigenschaften über eine Dauer von über 100 Zellpassagen ...
Göke, Rüdiger (Prof. Dr. med.), Kim, Dong-Hun   +1 more
core   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source