Results 101 to 110 of about 152,806 (342)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Insulin-like growth factor I (IGF-I) in a growth-enhanced transgenic (GH-overexpressing) bony fish, the tilapia ( Oreochromis niloticus ): indication for a higher impact of autocrine/paracrine than of endocrine IGF-I [PDF]

, 2018
Several lines of growth hormone (GH)-overexpressing fish have been produced and analysed for growth and fertility parameters. However, only few data are available on the growth-promoting hormone insulin-like growth factor I (IGF-I) that mediates most ...
Caelers, Antje, Eppler, Elisabeth, Hwang, Guylin, Maclean, Norman, Rahman, Azizur, Reinecke, Manfred, Shved, Natallia, Zapf, Jürgen   +7 more
core  

Growth Hormone and Insulin-Like Growth Factor-I alter Hippocampal Excitatory Synaptic Transmission in Young and Old Rats [PDF]

, 2013
Cataloged from PDF version of article.In rats, as in humans, normal aging is characterized by a decline in hippocampal-dependent learning and memory, as well as in glutamatergic function.
Adams, M. M., Ariwodola, O. J., Brunso Bechtold, J. K., Molina, D. P., Weiner, J. L.   +4 more
core   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin

Frontiers in Endocrinology
Growth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in healthy states. However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH ...
Kevin C. J. Yuen, Rikke Hjortebjerg, Rikke Hjortebjerg, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, David R. Clemmons, Jan Frystyk, Jan Frystyk   +9 more
doaj   +1 more source

Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females

Journal of Translational Medicine, 2011
Background Fat mass (FM) in overweight/obese subjects has a primary role in determining low-grade chronic inflammation and, in turn, insulin resistance (IR) and ectopic lipid storage within the liver.
Lombardi Gaetano, Orio Francesco, Rossi Annalisa, Nedi Valeria, De Rosa Annalba, Di Somma Carolina, Pizza Genoveffa, Savastano Silvia, Colao Annamaria, Tarantino Giovanni   +9 more
doaj   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Transfer of insulin-like growth factors I and II from plasma to lymph in young goats [PDF]

, 1992
The plasma clearance of intravenously injected '25I-labelled insulin-like growth factor I (IGFI, n = 13) and IGF-II (n = 12) and their transfer into lymph draining the foreleg of 3 5- to 8- week-old British Saanen goats was studied.
Baucells Sánchez, María Dolores, Fleet, I.R., Prosser, C.G.   +2 more
core   +2 more sources

Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy

Advanced Science, EarlyView.
As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang, Renjie Tan, Shuo Meng, Ke Zhang, Jinlian Hu   +4 more
wiley   +1 more source

Insulin-like growth factor -I deficiency, insulin sensitivity, and glucose metabolism [PDF]

, 2013
In children and adolescents, growth hormone (GH) and insulin-like growth factor-I (IGF-I) act in concert to stimulate linear growth; however, the effects on glucose metabolism are in opposition. GH increases insulin resistance by lipolysis. In contrast,
Ekström, Klas
core   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source