Results 161 to 170 of about 152,806 (342)
Intergenerational Enlargement of Human Organs as a Driver of Increased Cancer Risk?
BioEssays, Volume 47, Issue 8, August 2025.Identifying the environmental factors and associated mechanisms driving increased cancer incidence in younger generations is a matter of great urgency. Here, we propose and discuss a new potential mechanism: larger organ sizes in younger individuals resulting from intergenerational differences in lifestyle, diet, and environmental exposures.
Costas Koufaris, Vicky Nicolaidou
wiley +1 more source
Untangling IGF-I signaling in the aging brain. [PDF]
Aging (Albany NY), 2023 Zegarra-Valdivia J, Nuñez A, Aleman IT.
europepmc +1 more source
What Epigenetics Teaches Us About Neuron–Glioma Interactions
BioEssays, EarlyView.Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty +2 more
wiley +1 more source
Insulin-Like Growth Factor I: a Modulator of Erythropoiesis in Uraemic Patients? [PDF]
, 2017 Anaemia is a feature almost invariably complicating chronic renal failure. Its pathophysiology is multifactorial but the most important cause is erythropoietin (Epo) deficiency.
Bonnardeaux, A. +4 more
core
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I [PDF]
, 2002 We have previously shown that the administration of low doses of insulin-like growth factor-I (IGF-I) to CCl4-cirrhotic rats improves liver function and reduces fibrosis.
Avila, M.A. (Matías Antonio) +8 more
core
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior. [PDF]
Life Sci Alliance, 2023 Herrero-Labrador R +12 more
europepmc +1 more source
Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein 1 gene transcription by hormones and provision of amino acids in rat hepatocytes. [PDF]
, 1993 C I Pao +6 more
openalex +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source