Results 31 to 40 of about 152,806 (342)

Free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus [PDF]

, 1997
The existing literature on serum insulin-like growth factor I (IGF-I) levels in insulin-dependent diabetes mellitus (IDDM) is conflicting. Free IGF-I may have greater physiological and clinical relevance than total IGF-I.
Derkx, F.H.M. (Frans), Jacobs, M.L. (Marloes), Janssen, J.A.M.J.L. (Joop), Lamberts, S.W.J. (Steven), Lely, A-J. (Aart-Jan) van der, Weber, R.F.A. (Robert)   +5 more
core   +3 more sources

IGF-I, IGF-II and insulin stimulate different gene expression responses through binding to the IGF-I receptor.

Frontiers in Endocrinology, 2013
Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor.
Soetkin eVersteyhe, Birgit eKlaproth, Rehannah eBorup, Jane ePalsgaard, Maja eJensen, Steven G. Gray, Steven G. Gray, Pierre eDe Meyts   +7 more
doaj   +1 more source

Normal Values of Circulating IGF-I Bioactivity in the Healthy Population: Comparison with five widely used IGF-I immunoassays [PDF]

, 2008
Background: IGF-I immunoassays are primarily used to estimate IGF-I bioactivity. Recently, an IGFI specific Kinase Receptor Activation Assay (KIRA) has been developed as an alternative method.
Chen, Chestnut, Clemmons, Clemmons, Collett-Solberg, Daughaday, Daughaday, Frystyk, Frystyk, Furlanetto, Geier, Ho, Jan Frystyk, Jones, Joseph A. M. J. L. Janssen, Karin Weber, Katy van der Wansem, Klapper, Laursen, Lazarus, Leo J. Hofland, LeRoith, Leung, Lu, Michael B. Ranke, Michael P. Brugts, Poehlman, Pokrajac, Quarmby, Ranke, Sadick, Salmon Jr, Scott, Steven W. J. Lamberts, Strasburger, Yu, Zapf   +36 more
core   +1 more source

Low Circulating IGF-I Bioactivity in Elderly Men is associated with Increased Mortality [PDF]

, 2008
Context: Low IGF-I signaling activity prolongs lifespan in certain animal models, but the precise role of IGF-I in human survival remains controversial.
A. W. van den Beld, Andreassen, Barbieri, Bartke, Blum, Carter, Chen, Clemmons, Clemmons, Collett-Solberg, de Ferranti, Frystyk, Frystyk, Gotfredsen, Holzenberger, J. A. M. J. L. Janssen, J. Frystyk, Janssen, Jeschke, K. van der Wansem, Kenyon, L. J. Hofland, Le Roith, Lin, M. P. Brugts, P. M. van Koetsveld, Ridker, Rincon, Rincon, S. W. J. Lamberts, Sadick, Sesmilo, Shimokawa, Stoving, Thum, van den Beld, Verma   +36 more
core   +2 more sources

Zmiany w stężeniach insulinopodobnych czynników wzrostu IGF-1 i IGF-2 i białek wiążących BP-2 i BP-3 w czasie leczenia ostrej białaczki limfoblastycznej [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2004
Cel pracy: Ocena dynamiki zmian w wartościach insulinopodobnych czynników wzrostu: IGF-1 i IGF-2 i białek wiążących: IGFBP-2 i IGFBP-3 w surowicy krwi dzieci z ostrą białaczką limfoblastyczną (ALL) w trakcie leczenia przeciwnowotworowego.
Maryna Krawczuk-Rybak, Anna Kitszel, Sławomir Wołczyński   +2 more
doaj  

Pleiotropic Effect of Hormone Insulin-Like Growth Factor-I in Immune Response and Pathogenesis in Leishmaniases

Journal of Immunology Research, 2021
Leishmaniases are diseases caused by several Leishmania species, and many factors contribute to the development of the infection. Because the adaptive immune response does not fully explain the outcome of Leishmania infection and considering that the ...
Luiza C. Reis, Eduardo Milton Ramos-Sanchez, Fernanda N. Araujo, Ariane F. Leal, Christiane Y. Ozaki, Orlando R. Sevillano, Bernardina A. Uscata, Hiro Goto   +7 more
doaj   +1 more source

Little effects of Insulin-like Growth Factor-I on testicular atrophy induced by hypoxia

BMC Urology, 2006
Background Insulin-like Growth Factor-I (IGF-I) supplementation restores testicular atrophy associated with advanced liver cirrhosis that is a condition of IGF-I deficiency.
Casares Amelia, Diaz-Sanchez Matias, Puche Juan, Garcia-Fernandez Maria, Castilla-Cortázar Inma, Diez-Caballero Fernando, Aliaga-Montilla M Aurelia, Rodriguez-Borrajo Coronación, Gonzalez-Barón Salvador   +8 more
doaj   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Bunsen, Thea, Fruth, Maximilian, Kraus, Steffen, Nägler, Dorit K.   +3 more
core   +1 more source

Long-term IGF-I exposure decreases autophagy and cell viability. [PDF]

PLoS ONE, 2010
A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types and has been found to have protective effects against multiple forms of damage in acute settings.
Alessandro Bitto, Chad Lerner, Claudio Torres, Michaela Roell, Marco Malaguti, Viviana Perez, Antonello Lorenzini, Silvana Hrelia, Yuji Ikeno, Michelle Elizabeth Matzko, Roger McCarter, Christian Sell   +11 more
doaj   +1 more source

Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016
Transthyretin (TTR) has a neuroprotective role in the central nervous system (CNS) in Alzheimer's disease (AD) and cerebral ischemia. Increased levels of TTR and activated insulin-like growth factor I receptor (IGF-IR) are associated with reduced neurodegeneration in an AD mouse model.
Maria João Saraiva, Sónia S. Leal, Marta Vieira, Cláudio M. Gomes   +3 more
openaire   +3 more sources