Results 31 to 40 of about 14,093,235 (401)

Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity. [PDF]

, 1996
We aimed to investigate the natural killer (NK) cell activity in hGH-deficient adults and to analyze the effect of insulin-like growth factor (IGF)-I in uivo and in vitro on NK cell activity.
C J Auernhammer, C J Strasburger, H Feldmeier, K Pachmann, R Nass   +4 more
core   +1 more source

IGF-I Bioactivity Better Reflects Growth Hormone Deficiency than Total IGF-I [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2011
GH is considered the main regulator of circulating IGF-I. Total (extractable) IGF-I is therefore routinely used for diagnosis of GH deficiency (GHD) and for monitoring treatment. Methods currently used for measurement of circulating total IGF-I may be hampered by interferences of IGF-binding proteins.
Varewijck, Aimee, Lamberts, S.W.J., Uitterlinden, Piet, Hofland, Leo, Janssen, J.A.M.J.L.   +4 more
openaire   +2 more sources

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Andress, Andress, Arai, Arai, Beattie, Bramani, Carrick, Chernausek, David J. Flint, Elizabeth Tonner, Firth, Galanis, Gordon J. Allan, Headey, Ho, Huhtala, Hwa, Iain F. Gow, Imai, James Beattie, John H. Shand, Kalus, Kirsten Phillips, Malgorzata Szymanowska, Nam, Nam, Parker, Parker, Payet, Phillips, Provencher, Roger A. Clegg, Schneider, Shand, Sharon M. Kelly, Song, Song, Vorwerk, Wang, Whitmore, Yan   +40 more
core   +1 more source

Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

Journal of Neuroscience, 2000
In several species, including humans, the dentate granule cell layer (GCL) of the hippocampus exhibits neurogenesis throughout adult life. The ability to regulate adult neurogenesis pharmacologically may be of therapeutic value as a mechanism for ...
M. Åberg, N. Åberg, Helena Hedbäcker, J. Oscarsson, P. Eriksson   +4 more
semanticscholar   +1 more source

Low Circulating IGF-I Bioactivity in Elderly Men is associated with Increased Mortality [PDF]

, 2008
Context: Low IGF-I signaling activity prolongs lifespan in certain animal models, but the precise role of IGF-I in human survival remains controversial.
A. W. van den Beld, Andreassen, Barbieri, Bartke, Blum, Carter, Chen, Clemmons, Clemmons, Collett-Solberg, de Ferranti, Frystyk, Frystyk, Gotfredsen, Holzenberger, J. A. M. J. L. Janssen, J. Frystyk, Janssen, Jeschke, K. van der Wansem, Kenyon, L. J. Hofland, Le Roith, Lin, M. P. Brugts, P. M. van Koetsveld, Ridker, Rincon, Rincon, S. W. J. Lamberts, Sadick, Sesmilo, Shimokawa, Stoving, Thum, van den Beld, Verma   +36 more
core   +2 more sources

Free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and their relationships to the presence of diabetic retinopathy and glomerular hyperfiltration in insulin-dependent diabetes mellitus [PDF]

, 1997
The existing literature on serum insulin-like growth factor I (IGF-I) levels in insulin-dependent diabetes mellitus (IDDM) is conflicting. Free IGF-I may have greater physiological and clinical relevance than total IGF-I.
Derkx, F.H.M. (Frans), Jacobs, M.L. (Marloes), Janssen, J.A.M.J.L. (Joop), Lamberts, S.W.J. (Steven), Lely, A-J. (Aart-Jan) van der, Weber, R.F.A. (Robert)   +5 more
core   +4 more sources

Changes in Insulin-Like Growth Factor-I and -II Associated with Fat but not Lean Mass in Early Old Age [PDF]

, 2015
Objective: To test the hypothesis that insulin-like growth factors-I and II (IGF-I and II) decline during late midlife and that greater declines are related to higher fat mass and lower lean mass.
Adams, Andersen, Ben-Shlomo, Benn, Berryman, Bidlingmaier, Birnie, Burgers, Chaston, Cooper, Crowe, Crowe, Firth, Flegal, Harris, Holly, Holt, Huang, Jakobsdottir, Junnila, Klinger, Kuh, Kuk, Livingstone, Lukanova, Martin, Nindl, Nindl, Nindl, O'Connor, Parekh, Rejeski, Rodriguez, Sandhu, Schrager, Seck, Soubry, Vestergaard, Wolfe, Ye   +39 more
core   +2 more sources

Zmiany w stężeniach insulinopodobnych czynników wzrostu IGF-1 i IGF-2 i białek wiążących BP-2 i BP-3 w czasie leczenia ostrej białaczki limfoblastycznej [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2004
Cel pracy: Ocena dynamiki zmian w wartościach insulinopodobnych czynników wzrostu: IGF-1 i IGF-2 i białek wiążących: IGFBP-2 i IGFBP-3 w surowicy krwi dzieci z ostrą białaczką limfoblastyczną (ALL) w trakcie leczenia przeciwnowotworowego.
Maryna Krawczuk-Rybak, Anna Kitszel, Sławomir Wołczyński   +2 more
doaj  

Little effects of Insulin-like Growth Factor-I on testicular atrophy induced by hypoxia

BMC Urology, 2006
Background Insulin-like Growth Factor-I (IGF-I) supplementation restores testicular atrophy associated with advanced liver cirrhosis that is a condition of IGF-I deficiency.
Casares Amelia, Diaz-Sanchez Matias, Puche Juan, Garcia-Fernandez Maria, Castilla-Cortázar Inma, Diez-Caballero Fernando, Aliaga-Montilla M Aurelia, Rodriguez-Borrajo Coronación, Gonzalez-Barón Salvador   +8 more
doaj   +1 more source

Long-term IGF-I exposure decreases autophagy and cell viability. [PDF]

PLoS ONE, 2010
A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types and has been found to have protective effects against multiple forms of damage in acute settings.
Alessandro Bitto, Chad Lerner, Claudio Torres, Michaela Roell, Marco Malaguti, Viviana Perez, Antonello Lorenzini, Silvana Hrelia, Yuji Ikeno, Michelle Elizabeth Matzko, Roger McCarter, Christian Sell   +11 more
doaj   +1 more source