Results 81 to 90 of about 152,806 (342)

The in vitro and in vivo effects of human growth hormone administration on tumor growth of rats bearing a transplantable rat pituitary tumor (7315b) [PDF]

, 1990
The direct effects of human GH and IGF-I on PRL secretion and cell proliferation were studied on PRL secreting rat pituitary tumor 7315b cells in vitro, as well as the effects in vivo of human GH administration on body weight, IGF-I levels and tumor size
Binnerts, A. (Arjen), Hofland, L.J. (Leo), Koetsveld, P.M. (Peter) van, Lamberts, S.W.J. (Steven), Uitterlinden, P. (Piet)   +4 more
core   +1 more source

Do IGF-I concentrations better reflect growth hormone (GH) action in children with short stature than the results of GH stimulating tests? Evidence from the simultaneous assessment of thyroid function

Thyroid Research, 2011
Background The diagnosis of growth hormone (GH) deficiency (GHD) in short children seems unquestionable when both GH peak in stimulating tests (GHST) and IGF-I concentration are decreased.
Smyczyńska Joanna, Stawerska Renata, Lewiński Andrzej, Hilczer Maciej   +3 more
doaj   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv [PDF]

, 2004
This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display
Roberts, Anthony Simon
core   +1 more source

PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver [PDF]

, 2003
Humans afflicted with the Wolcott-Rallison syndrome and mice deficient for PERK (pancreatic endoplasmic reticulum eIF2α kinase) show severe postnatal growth retardation.
CAVENER Douglas R, FRANK Ami, GABAI Aryn, IIDA Kaori, LI Sheng’ai, LI Yulin, LIANG Shun-Hsin, O’NEIL Jeff, ROSEN Clifford J, ZAMBITO Frank, ZHANG Peichuan, 香穂里 飯田   +11 more
core   +2 more sources

Bidirectional modulation of synaptic transmission by insulin-like growth factor-I

Frontiers in Cellular Neuroscience
Insulin-like growth factor-I (IGF-I) plays a key role in the modulation of synaptic plasticity and is an essential factor in learning and memory processes.
José Antonio Noriega-Prieto, José Antonio Noriega-Prieto, Laura Eva Maglio, Paloma Perez-Domper, Paloma Perez-Domper, José Carlos Dávila, José Carlos Dávila, Antonia Gutiérrez, Antonia Gutiérrez, Ignacio Torres-Alemán, Ignacio Torres-Alemán, Ignacio Torres-Alemán, David Fernández de Sevilla   +12 more
doaj   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Kidney growth in normal and diabetic mice is not affected by human insulin-like growth factor binding protein-1 administration [PDF]

, 2005
Insulin-like growth factor I (IGF-I) accumulates in the kidney following the onset of diabetes, initiating diabetic renal hypertrophy. Increased renal IGF-I protein content, which is not reflected in messenger RNA (mRNA) levels ...
Cingel-Ristic, V., Drop, S.L.S. (Stenvert), Flyvbjerg, A. (Allan), Han, V.K., Rasch, R., Schrijvers, B.F., Vliet, A.K. (Arlène) van   +6 more
core   +2 more sources

Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2019
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer’s disease (AD). Studies on the association between IGF-I levels and dementia risk have been inconclusive.
Sara A. Galle, Sara A. Galle, Ashley van der Spek, Madeleine L. Drent, Madeleine L. Drent, Michael P. Brugts, Erik J. A. Scherder, Joseph A. M. J. L. Janssen, M. Arfan Ikram, M. Arfan Ikram, M. Arfan Ikram, Cornelia M. van Duijn, Cornelia M. van Duijn   +12 more
doaj   +1 more source