Results 161 to 170 of about 92,734 (184)

Mature IGF-II prevents the formation of “big” IGF-II/IGFBP-2 complex in the human circulation

Growth Hormone & IGF Research, 2010
IGF-II plays an important role in physiological and pathological processes involved in growth and metabolism. Despite the fact that "big" IGF-IIs, IGF-II(1-87) and IGF-II(1-104), have been identified in the circulation for decades in addition to "mature" IGF-II, the biological properties of these "big" IGF-IIs and the mechanisms regulating their ...
Qing, Qiu, Xiaojuan, Yan, Michael, Bell, Jianmin, Di, Benjamin K, Tsang, Andrée, Gruslin   +5 more
openaire   +2 more sources

IGF-II promoter methylation and ovarian cancer prognosis

Journal of Cancer Research and Clinical Oncology, 2007
The insulin-like growth factor-II (IGF-II) gene has four promoters that produce distinct transcripts which vary by tissue type and developmental stage. Dysregulation of normal promoter usage has been shown to occur in cancer; DNA methylation regulates promoter use.
A C, Beeghly, D, Katsaros, A L, Wiley, I A, Rigault de la Longrais, A T, Prescott, H, Chen, M, Puopolo, T J, Rutherford, H, Yu   +8 more
openaire   +2 more sources

Tumour‐induced hypoglycaemia due to ‘big’ IGF–II

Journal of Internal Medicine, 1994
Abstract. A 57‐year‐old woman with a slowly growing intraabdominal leiomyosarcoma developed life‐threatening hypoglycaemia. Plasma C‐peptide levels were low (0.08 nmol L‐1 and < 0.05 nmol L‐1, reference interval 0.18–0.63 nmol L‐1). Total IGF–II was normal (760 ng mL‐1) whilst ‘big’ IGF–II was markedly elevated (440 ng mL‐1).
G, Strauss, L, Christensen, J, Zapf
openaire   +2 more sources

Expression of IGF-II, the IGF-II/Mannose-6-Phosphate Receptor and IGFBP-2 During Rat Embryogenesis

1991
It is becoming increasingly apparent that the IGF system (including both IGF-I and IGF-II, at least two IGF receptors, and a family of at least six IGF binding proteins; 1-3) has a fundamental role in the normal progression of prenatal development. The initial observation that IGF-II peptide levels were high in the fetus but decreased post-natally (4 ...
J E, Pintar, T L, Wood, R D, Streck, L, Havton, L, Rogler, M S, Hsu   +5 more
openaire   +2 more sources

Insulin-Like Growth Factor II (IGF-II) and the IGF-II/ Mannose-6-Phosphate Receptor: The Myth Continues

Hormone Research, 1994
Insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin. It is now thought that IGF-II acts as a growth factor during fetal life and development. In rats, IGF-II levels in the circulation are high in the fetus and decline rapidly after birth.
W, Kiess, Y, Yang, U, Kessler, A, Hoeflich   +3 more
openaire   +2 more sources

Purification and characterization of insulin-like growth factor II (IGF II) and an IGF II variant from human placenta

Journal of Chromatography B: Biomedical Sciences and Applications, 1995
In order to purify variant IGF II peptides from human placenta, we have developed a purification procedure combining heparin affinity chromatography and cation-exchange, reversed-phase and size-exclusion HPLC. Two peptides were purified, both having apparent M(r) values of ca. 7300 Da as evaluated by SDS-PAGE.
F, De Ceuninck, J, Willeput, M, Corvol
openaire   +2 more sources

IGF‐I, IGF‐II, and IGF‐receptor‐1 transcript and IGF‐II protein expression in myostatin knockout mice tissues

Muscle & Nerve, 2002
AbstractSemiquantitative reverse transcriptase–polymerase chain reaction (RT‐PCR) and immunohistochemistry were performed to demonstrate whether a correlation exists between insulin‐like growth factors (IGFs)—positive regulators of growth—and myostatin, a negative regulator of muscle growth.
Hakan, Kocamis, Scott A, Gahr, Lori, Batelli, Ann F, Hubbs, John, Killefer   +4 more
openaire   +2 more sources

Human colon carcinoma cells ( CaCo-2) synthesize IGF-II and express IGF-I receptors and IGF-II/M6P receptors

Molecular and Cellular Endocrinology, 1994
The IGFs have been implicated in the development of the intestinal tract. We have studied the human colon carcinoma cell line CaCo-2 to gain more insight into the function of the IGFs in the gut. [125I]IGF-I and -II bound specifically to CaCo-2 cells as measured in competitive binding experiments.
A, Hoeflich, Y, Yang, U, Kessler, P, Heinz-Erian, H, Kolb, W, Kiess   +5 more
openaire   +2 more sources

Tumor Hypoglycemia Linked to IGF-II

1999
Hypoglycemia is a common medical emergency, most often due to untoward effects of insulin administered to patients with diabetes mellitus. It is also a manifestation of many other medical conditions including tumors. The hypoglycemia associated with tumors occurs within a subset of patients who have “spontaneous” or fasting hypoglycemia, i.e., the fall
Christian A. Koch, Kristina I. Rother, Jesse Roth   +2 more
openaire   +1 more source

Role of the IGF‐II receptor in mediating acute, non‐genomic effects of retinoids and IGF‐II on keratinocyte cell death

Experimental Dermatology, 2003
Abstract:  In this study, we have examined the effects of retinoic acid (RA) on the human immortalized keratinocyte cell line (HaCaT). A significant twofold (P < 0.01) increase in apoptotic cell death compared with the control was found within 24 h of treatment with 10−5 M of RA. Apoptosis was confirmed by flow cytometry.
Louafi, F., Stewart, Claire E., Perks, C. M., Thomas, M. G., Holly, Jeff   +4 more
openaire   +3 more sources