Multigenerational downregulation of insulin/IGF-1 signalling in adulthood improves lineage survival, reproduction, and fitness in C. elegans supporting the developmental theory of ageing [PDF]
Elizabeth Duxbury +6 more
openalex +1 more source
Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao +6 more
wiley +1 more source
Insulin-like growth factor-1/insulin-like growth factor-1 receptor signalling in macrophages facilitates recovery from acute lung injury. [PDF]
Niisato M +5 more
europepmc +1 more source
Fitting of mechanical material behaviour of structural steel for numerical modelling
Abstract Numerical simulations are widely used in structural engineering research, and validated models enable the efficient expansion of datasets without costly additional testing. They allow the investigation of alternative geometries and loading scenarios beyond those covered by experiments.
Felix Eyben +2 more
wiley +1 more source
Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa +9 more
wiley +1 more source
Evolution of Insulin, Insulin-like Growth Factors, and Their Cognate Receptors in Vertebrates, Invertebrates, and Viruses. [PDF]
Chrudinová M +6 more
europepmc +1 more source
ABSTRACT Objectives Insulin‐like growth factor 1 receptor (IGF‐1R) is crucial for immunological control and the development of different types of cancer. It is still uncertain how the expression of IGF‐1R impacts hypopharyngeal squamous cell carcinoma (HPSCC) and whether it has any predictive value for prognosis.
Wen‐Jing Li +10 more
wiley +1 more source
Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review). [PDF]
Cui RM +8 more
europepmc +1 more source

