Results 41 to 50 of about 150,785 (321)

Precise mapping of an IGF-I-binding site on the IGF-1R [PDF]

Biochemical Journal, 2006
The IGF-1R [type 1 IGF (insulin-like growth factor) receptor] is activated upon binding to IGF-I and IGF-II leading to cell growth, survival and migration of both normal and cancerous cells. We have characterized the binding interaction between the IGF-1R and its ligands using two high-affinity mouse anti-IGF-1R mAbs (monoclonal antibodies), 7C2 and ...
Keyhanfar, M., Booker, G., Whittaker, J., Wallace, J., Forbes, B.   +4 more
openaire   +4 more sources

Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis

Advanced Science, EarlyView.
The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu, Kristen D. Popowski, Christina M. Eckhardt, Weihang Zhang, Junlang Li, Yujia Jing, Dylan Silkstone, Elizabeth Belcher, Megan Cislo, Shiqi Hu, Halle Lutz, Asma Ghodsi, Mengrui Liu, Phuong‐Uyen C. Dinh, Ke Cheng   +14 more
wiley   +1 more source

Acceptance and commitment therapy reduces perceived ostracism in suicidal patients

Annals of General Psychiatry
Introduction Ostracism increases the risk of depression and suicidal behaviors. Mindfulness training, which is at the core of third-wave behavioral therapies such as acceptance and commitment therapy (ACT), might reduce social distress and inhibit ...
Emilie Olié, Manon Malestroit, Véronique Brand-Arpon, Philippe Courtet, Deborah Ducasse   +4 more
doaj   +1 more source

Spectral Properties of the Generalized Spin-Fermion Models [PDF]

International Journal of Modern Physics B13 (1999) 2573-2605, 2002
In order to account for competition and interplay of localized and itinerant magnetic behaviour in correlated many body systems with complex spectra the various types of spin-fermion models have been considered in the context of the Irreducible Green's Functions (IGF) approach. Examples are generalized d-f model and Kondo-Heisenberg model.
arxiv   +1 more source

Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1 [PDF]

Biochemical Journal, 1989
(1) Many cell types secrete insulin-like growth factor (IGF)-binding proteins that can be expected to sequester free IGF and modify the biological activities of the growth factors. (2) A binding protein purified from bovine kidney (MDBK) cells potently inhibited the ability of IGF-2 to stimulate DNA synthesis or protein accumulation as well as to ...
M Ross, G L Francis, F. J. Ballard, L Szabo, J C Wallace   +4 more
openaire   +3 more sources

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

Organic & Biomolecular Chemistry, 2016
Convergent-based synthesis of native IGF-II and two IGF-II analogues, with coumarin fluorescent probes incorporated at residues 19 and 28, and their use in FRET-based identification of interactions with the type 1 insulin-like growth factor receptor (IGF-IR).
P. W. R. Harris, Briony E. Forbes, Briony E. Forbes, Andrew D. Abell, Denis B. Scanlon, Margaret A. Brimble, J. M. Cottam Jones   +6 more
openaire   +5 more sources

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Advanced Science, EarlyView.
Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma   +12 more
wiley   +1 more source

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

Notiziario IGF n.19

Fracture and Structural Integrity, 2013
1) Editoriale del Segretario IGF; 2) Verbale dell'Assemblea Annuale dei Soci 2007; 3) Verbali dei Consigli di Presidenza; 4) Cariche sociali biennio 2007-2009; 5) Resoconti delle attività TC-ESIS nel 2007; 6) Summer School IGF 2008; 7) Convocazione
Francesco Iacoviello
doaj   +3 more sources