Results 91 to 100 of about 29,583 (184)

Insulin‐like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

EMBO Molecular Medicine, 2014
Insulin‐like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic administration of recombinant IGF2 enhances memory.
Maria Pascual‐Lucas, Silvia Viana da Silva, Marianna Di Scala, Carolina Garcia‐Barroso, Gloria González‐Aseguinolaza, Christophe Mulle, Cristina M Alberini, Mar Cuadrado‐Tejedor, Ana Garcia‐Osta   +8 more
doaj   +1 more source

Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This study evaluates Xiaoyaosan (XYS) for bipolar disorder (BD) using network pharmacology and experimental validation. Molecular docking reveals interactions between active XYS compounds and potential core targets. Animal experiments confirm XYS alleviates BD‐like behaviors in mice by suppressing core targets, elucidating its multi‐target mechanism ...
Man Chen, Nana Ding, Xingmin Qiu, Lan Li, Yali Guo, Rongyanqi Wang, Xiaowei Mo, Tan Zou, Shangzhen Yu, Xiaojuan Li, Jiaxu Chen   +10 more
wiley   +1 more source

miR-491-5p functions as a tumor suppressor by targeting IGF2 in colorectal cancer

, 2019
Lei Lu,* Ming Cai,* Meixia Peng, Fei Wang, Xiaofeng Zhai Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China *These authors contributed equally to this work Background: Dysregulation of ...
Lu L, Cai M, Zhai X, Wang F, Peng M
core  

Transcriptional breakpoints as predictors of thermal thresholds in a climate‐impacted stenothermal fish

Functional Ecology, Volume 40, Issue 10, Page 3034-3047, October 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The biogeography of ectotherms is greatly influenced by their thermal tolerance, which is expected to be tightly coupled to aerobic performance. However, preferred temperatures of ectotherms often deviate substantially from aerobic performance optima. This suggests that
Analisa Lazaro‐Côté, Travis C. Durhack, Matthew M. Guzzo, Andrew J. Chapelsky, Benjamin C. Kissinger, Ken M. Jeffries, Neil J. Mochnacz   +6 more
wiley   +1 more source

Alignments of IGF2 signal peptides.

, 2019
Amino acid sequences of IGF2 signal peptides from 19 mammals are shown in single letter code. A. 24-, 26-, or 28-residue IGF2 signal peptide 1 is found in all species except platypus. B. 80-, 85-, or 88-amino acid presumptive IGF2 signal peptide 2 can be
Kabita Baral (6894350), Peter Rotwein (90594)   +1 more
core   +1 more source

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Aging Cell, Volume 25, Issue 10, October 2026.
Single‐cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age‐enriched Neu06‐IL6 neutrophil state and predicts IL‐6 as one of a candidate regulator for neutrophil remodeling.
Yuman Wang, Teding Chang, Yangguang Fu, Guangyu Liang, Huicheng Liu, Le Zhang, Jinhua Yan, Man Liu, Anding Liu, Cuntai Zhang   +9 more
wiley   +1 more source

Phylogenetic analysis of Igf1, Igf2 and Igf3 in vertebrates.

, 2016
NJ phylogenetic tree of Igf3 using the deduced aa sequences of C. carpio and the Igf1, Igf2 and Igf3 deduced aa sequences of other species in the GenBank database: Homo sapiens (Igf1a: AAA52538.1, Igf1b: AAA52537.1, Igf2: AAA60088.1), Mus musculus (Igf1:
Jianjun Fu (697996), Feibiao Song (3597857), Wenbin Zhu (159121), Zaijie Dong (558988), Lanmei Wang (109282), Juanjuan Dong (3597854)   +5 more
core   +1 more source

The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes

Diabetic Medicine, Volume 43, Issue 10, October 2026.
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald, Yasitha lllangasekera, Andreas Matheou, Ram Prakash Narayanan, Stephen White, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, William Ollier, Graham A. Hitman, Ritwika Mallik, Philip A. Kalra, Martin Whyte, J. Martin Gibson   +13 more
wiley   +1 more source

The preparation and characterization of IGF2 prohormones

, 2022
Insulin-like growth factors 1 and 2 are protein hormones that share similar structural and functional features with insulin. They are commonly abbreviated as IGF1 and IGF2.
Potalitsyn, Pavlo
core  

Neural Cell Models of Specific Reading Disabilities: Identification of Cellular and Transcriptome Alterations

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
Neural cell phenotypes were tested using cells derived from two pairs of siblings strongly discordant for reading—probands with severe RD and their strong‐reader siblings. We observed significant differences in outgrowth in the neurosphere assay using the neural precursor cells (NPCs) derived from the probands compared to cells from their strong‐reader
Cathy L. Barr, Karen G. Wigg, Yu Feng, Kirsten Blokland, Margaret Wilkinson, Elizabeth N. Kerr, Sharon L. Guger, Maureen W. Lovett, Lisa J. Strug, Ruth Oefner, Simone Benassi, Fred H. Gage, Maria C. Marchetto   +12 more
wiley   +1 more source