Results 111 to 120 of about 7,271 (197)

Glucose-dependent control of insulin like growth factor 2 mRNA binding protein 2 and other gene expressions in ERN1 knockdown glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum stress and glucose supply are significant factors in glioblastoma growth. The present study aims to investigate the impact of glucose-dependent control of IGF2BP2, TOB1, HBEGF, TWIST1, CCNH, and E2F1 gene expression in ...
Minchenko Oleksandr H., Viletska Yuliia M., Sliusar Myroslava Y., Hnatiuk Oksana S., Ratushna Oksana O., Feldman Taia V., Kozynkevych Halyna E., Bezrodnyi Borys H., Minchenko Dmytro O.   +8 more
doaj   +1 more source

IGF2BP2 wt Allele [PDF]

, 2020
openaire   +1 more source

The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis

Background Pancreatic cancer is a highly malignant digestive tumor. Glutamine metabolism is one of the important sources of tumors. N6-methyladenosine (m6A) modification plays a key role in regulating tumor metabolism and holds promise as a therapeutic ...
Weiguo Long, Xu Wang, Min Xu, Yuting Wu, Deqiang Wang, Xi Pu, Xinyu Sun, Xiao Yuan   +7 more
core   +1 more source

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

eLife
Zika virus (ZIKV) infection causes significant human disease that, with no approved treatment or vaccine, constitutes a major public health concern. Its life cycle entirely relies on the cytoplasmic fate of the viral RNA genome (vRNA) through a fine ...
Clément Mazeaud, Stefan Pfister, Jonathan E Owen, Higor Sette Pereira, Flavie Charbonneau, Zachary E Robinson, Anaïs Anton, Cheyanne L Bemis, Aïssatou Aïcha Sow, Trushar R Patel, Christopher J Neufeldt, Pietro Scaturro, Laurent Chatel-Chaix   +12 more
doaj   +1 more source

Dual Disruption of EGFR/PI3K Signaling: IGF2BP2 Targeting Reverses Anti-EGFR Resistance in CAFs-Infiltrated Oral Squamous Cell Carcinoma

RNA-binding proteins (RBPs) critically regulate post-transcriptional gene networks, yet their roles and mechanisms in oral squamous cell carcinoma (OSCC) remain underexplored.
Yanan Sun, Yaying Hu, Yiwei Li, Junchen Pan, Jiyuan Ma, Tianshuang Zhu, Sheng Nong, Jiali Zhang   +7 more
core   +1 more source

IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2

Investigative Ophthalmology & Visual Science
N6-methyladenosine (m6A) methylation is a chemical modification that occurs on RNA molecules, where the hydrogen atom of adenine (A) nucleotides is replaced by a methyl group, forming N6-methyladenosine. This modification is a dynamic and reversible process that plays a crucial role in regulating various biological processes, including RNA stability ...
Wu, Siqi, Li, Fuxi, Mo, Kunlun, Huang, Huaxing, Yu, Yankun, Huang, Ying, Liu, Jiafeng, Li, Mingsen, Tan, Jieying, Lin, Zesong, Han, Zhuo, Wang, Li, Ouyang, Hong   +12 more
openaire   +2 more sources

IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome

Immunity, Inflammation and Disease
Background Recent studies show that N6‐methyladenosine (m6A) plays an important role in the pathogenesis of the Alzheimer's disease (AD), while the mechanisms involved were studied insufficiently.
Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le   +3 more
doaj   +1 more source

IGF2BP2 Shapes the Tumor Microenvironment by Regulating Monocyte and Macrophage Recruitment in Bladder Cancer

Cancer Medicine
Background Immunotherapy has shown promise for bladder cancer (BC) treatment but is effective only in a subset of patients. Understanding the tumor microenvironment (TME) and its regulators, such as the expression of N6‐methyladenosine (m6A) regulators ...
Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Lizhao Wang, Quanpeng Qiu, Rundong Song, Yuanchun Pu, Yuanquan Zhang, Nan Mei, Mengzhao Zhang, Jinhai Fan   +13 more
doaj   +1 more source

Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene

Hereditas
Background Cisplatin (DDP) resistance has long posed a challenge in the clinical treatment of lung cancer (LC). Insulin-like growth factor 2 binding protein 2 (IGF2BP2) has been identified as an oncogenic factor in LC, whereas its specific role in DDP ...
Shilei Zhang, Ting Dou, Hong Li, Hongfang Yu, Wei Zhang, Liping Sun, Jingwen Yang, Zhenfei Wang, Hao Yang   +8 more
doaj   +1 more source

RNA-binding protein IGF2BP2 suppresses metastasis of clear cell renal cell carcinoma by enhancing CKB mRNA stability and expression

Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer, with a highly aggressive phenotype and poor prognosis. RNA binding proteins (RBPs) play crucial roles in post-transcriptional gene regulation and have been implicated in ...
Ce Liang, Yongquan Wang, Yuying Zhang, Xiaojuan Pan, Qiang Ma, Ai Ran, Bin Xiao, Yuying Liu, Yan Jiang, Junwu Ren, Haiping Li, Bo Huang, Wei Li, Changhong Qin, Shimin Wang, Feifei Yang, Hao Ning, Xiaolin Wang   +17 more
core   +1 more source