Results 101 to 110 of about 7,271 (197)

The m6A reader IGF2BP2 promotes proinflammatory signaling in Lupus nephritis by recognizing STAT1 m6A modifications

Autoimmunity
Characterized by renal inflammation and structural damage, lupus nephritis (LN) is a severe and often debilitating complication of systemic lupus erythematosus.
ChangZhi Zheng, XianMei Xu, Di Wu, Run Cheng, YouWei Bai, DeGuang Wang   +5 more
doaj   +1 more source

Investigation of Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Gene Polymorphisms in Type 2 Diabetes Patients

Genel Tıp Dergisi
Background/Aims: Type 2 diabetes (T2D) whose prevalance differs in different populations is a multifactorial disease. T2D is describes a group of clinical syndromes resulting from glucose metabolism disorders triggered by genetic
Duygu Yolal Ertural, Ümit Çınkır, Nurcan Aras   +2 more
doaj   +1 more source

HMGA2-IGF2BP2 Axis Regulates Muscle Stem Cell Activation and Myogenesis

, 2014
A group of genes were identified that are highly and specifically expressed in proliferating skeletal myoblasts during myogenesis. Temporal regulation of one of these, HMGA2, is required for satellite cell activation and expansion.
Gilbert, Jason, Eash, John, Zhang, Yunyu, Glass, David, Li, Zhizhong   +4 more
core  

Mechanism of IGF2BP2 regulation of PPAR-γ/GLUT4 pathway in insulin resistance induced by sodium arsenite exposure in HepG2 cells

环境与职业医学
BackgroundArsenic is an environmentally harmful substance that causes hepatic insulin resistance and liver damage, increasing the risk of type 2 diabetes mellitus.
Shiqing XU, Zhida HU, Qiyao ZHANG, Siqi ZHAO, Yujie WANG, Xiaohui WANG, Teng MA, Li WANG   +7 more
doaj   +1 more source

Pan-cancer analysis identified IGF2BP2 as a potential prognostic biomarker for multiple tumor types

Egyptian Journal of Medical Human Genetics
Background Insulin-like growth factor 2 (IGF2) mRNA-binding proteins 2 (IGF2BP2/IMP2), an RNA-binding protein encoded by the IGF2BP2 gene, exerts its influence across diverse pathological pathways.
Hong-Lu Zhou, Dan-Dan Chen, Xiu-Ling Li
doaj   +1 more source

The Potential Role of SNRPD1 Stabilized by IGF2BP2 in the Progression of Triple-Negative Breast Cancer

Breast Cancer: Targets and Therapy
Siqi Liu, Xin Sun, Na Liu, Fangcai Lin Department of Breast Surgery, Beijing Electric Power Hospital, Beijing, 100071, People’s Republic of ChinaCorrespondence: Fangcai Lin, Beijing Electric Power Hospital, Beijing, 100071, People’s Republic of China ...
Liu S, Sun X, Liu N, Lin F
doaj  

The p58 isoform of IGF2BP2 is generated by leaky ribosomal scanning.

, 2013
A. A schematic representation of mIGF2BP2 mutants. Only the sequences surrounding the canonical translation initiation site and the internal Met69 are shown. The two putative translation initiation sites are in red.
Hang T. T. Le (329874), Alice M. Sorrell (329877), Kenneth Siddle (329879)   +2 more
core   +1 more source

The m6A reader IGF2BP2 promotes ESCC progression by stabilizing HDGF mRNA

Journal of Cancer Research and Therapeutics
ABSTRACT Objective: This study aimed to explore the role of IGF2BP2 in esophageal squamous cell carcinoma (ESCC) progression. Materials and Methods: The Cancer Genome Atlas (TCGA) dataset, transcriptome sequencing, and the Gene Expression Omnibus (GEO) dataset were used to
Yang, Jia, Sujing, Liu, Miao, Zhang, Xia, Wu, Xiangyu, Chen, Mengmeng, Xing, Xianghui, Hou, Wenpeng, Jiang   +7 more
openaire   +2 more sources

The role of IGF2BP2 in macrophage-mediated NLRP3 inflammasome activation in the pathogenesis of dry AMD

Biology Direct
Background Dry age-related macular degeneration (AMD) is a common chronic degenerative eye disease for which there is currently no effective treatment. Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a recently identified m6A reader that
Yuqing Zhao, Yu Zhang, Junfang Li, Yifei Zhang, Yi Qu   +4 more
doaj   +1 more source

IGF2BP2 Gene [PDF]

, 2020
openaire   +1 more source