Results 91 to 100 of about 7,271 (197)

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria

Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.
Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet, Jérémy Le Luyer, Hélène Auger, Maximilian Haeussler, Guillaume Rivière   +4 more
wiley   +1 more source

Image1_AhR Antagonist Promotes Differentiation of Papillary Thyroid Cancer via Regulating circSH2B3/miR-4640-5P/IGF2BP2 Axis.TIF

, 2021
Abnormally high expression of aryl hydrocarbon receptor (AhR) has been implicated in dedifferentiation of radioiodine-refractory papillary thyroid cancer (RR-PTC).
Meiliang Guo (11871101), Feng Guan (725911), Ri Sa (11871098), Danyan Liu (11871104)   +3 more
core   +1 more source

Insulin‐Like Growth Factor 2 mRNA‐Binding Protein 2 (IGF2BP2) Promotes Castration‐Resistant Prostate Cancer Progression by Regulating AR‐V7 mRNA Stability

Cancer Reports
Background The emergence of constitutively active androgen receptor (AR) splice variant AR‐V7 poses a formidable challenge in treating prostate cancer, as it lacks the ligand binding region targeted by androgen‐deprivation therapies such as enzalutamide ...
Taruna Saini, Devesh Srivastava, Rajnikant Raut, Parul Mishra, Ashish Misra   +4 more
doaj   +1 more source

Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation.

, 2012
IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to bind to several different mRNAs in mammalian cells, including one of the mRNAs encoding insulin-like growth factor-2.
Hang T T Le, Alice M Sorrell, Le Hang T. T., Sorrell Alice M., Kenneth Siddle, Siddle Kenneth   +5 more
core   +1 more source

Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function

, 2021
N6-methyladenosine (m6A) on mRNA plays critical roles in various cellular processes. However, the landscape and dynamics of m6A modification in hematopoietic system remain unknown.
Zhang, Tiantian, Cheng, Ying, Wang, Qifan, Guo, Chengli, Jiang, Wei, Li, Yashu, Wang, Peipei, Li, Shaoguang, Cui, Manman, Hu, Jin, Wang, Jing, Han, Guoqiang, Zheng, Yuhuan, Zhang, Haojian, Xie, Xueqin, Gao, Kexin, Gao, Zhuying, Feng, Mengdie, Yin, Rong, Qiu, Qiang, Hu, Yiguo, Yang, Qing-Yong, Chang, Jiwei, Chai, Jihua   +23 more
core   +1 more source

Image2_AhR Antagonist Promotes Differentiation of Papillary Thyroid Cancer via Regulating circSH2B3/miR-4640-5P/IGF2BP2 Axis.TIF

, 2021
Abnormally high expression of aryl hydrocarbon receptor (AhR) has been implicated in dedifferentiation of radioiodine-refractory papillary thyroid cancer (RR-PTC).
Meiliang Guo (11871101), Feng Guan (725911), Ri Sa (11871098), Danyan Liu (11871104)   +3 more
core   +1 more source

HULC-IGF2BP2 Interaction Drives Proliferation and Metastasis in Colorectal Cancer

Journal of Cancer
Background: Highly Upregulated in Liver Cancer (HULC) has been shown to play a pro-carcinogenic role in various cancer types. However, the specific molecular mechanisms of HULC in colorectal cancer (CRC) remain unclear. This study aimed to investigate the interaction between HULC and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) in CRC ...
Pang, Qiang, Huang, Shansong, Wang, Huiying, Cao, Jiaqing   +3 more
openaire   +2 more sources

m6A reader IGF2BP2 promotes M2 macrophage polarization and malignant biological behavior of bladder cancer by stabilizing NRP1 mRNA expression

BMC Urology
Background Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has been confirmed to play oncogenic role in many cancers. However, the role and mechanism of IGF2BP2 in bladder cancer (BCa) still deserves to be further revealed. Methods The mRNA
Dian Fu, Xiuquan Shi, Xiaoming Yi, Ding Wu, Haowei He, Wenquan Zhou, Wen Cheng   +6 more
doaj   +1 more source

The Involvement of Insulin-Like Growth Factor 2 Messenger Ribonucleic Acid-Binding Protein 2 in the Regulation of the Expression of Breast Cancer-Related Genes

Breast Cancer: Targets and Therapy, 2022
Chao Gao,1 Li Li,2 Xixin Jin,1 Xinyu Song,1 Huiling Li,1 Xiaoli Xu,1 Chao Dong,1 Binlin Ma1 1State Key Laboratory of Pathogenes, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Breast and Thyroid Surgery, Affiliated ...
Gao C, Li L, Jin X, Song X, Li H, Xu X, Dong C, Ma B   +7 more
doaj  

N6-methyladenosine reader IGF2BP2 in T-cell lymphoma

Blood Journal
Peripheral T-cell lymphoma (PTCL) represents a highly heterogeneous and aggressive lymphoid neoplasm, lacking pathogenic biomarkers of RNA modification with therapeutic potential. IGF2BP2 is recognized as an N6-methyladenosine (m6A) reader, critically involved in oncogenesis.
Song Hu, Yao Qin, Hong-Mei Yi, Yao-Hui Huang, Shu Cheng, Cong Wang, Yunqi Li, Yu-Ran Ran Qiu, Ming-Ci Ci Cai, Yan Zhao, Peng-Peng Xu, Li Wang, Jie Xiong, Wei-Li Zhao   +13 more
openaire   +1 more source