Results 71 to 80 of about 7,271 (197)

IGF2BP2 gene polymorphism in patients with psoriasis

, 2017
Psoriasis is a chronic inflammatory disease with genetic transmission, the etiology of which has not been completely clarified yet. Insulin-like Growth Factor Binding Protein 2 (IGF2BP2) plays a role in growth, development, cellular differentiation, and ...
Kargun, Kursat, Kara, Murat, Kaya, Haktan, Demir, Betul, Bilik, Leyla, Çiçek, Demet   +5 more
core   +1 more source

N⁶-methyladenosine (m⁶A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1

, 2022
N6-methyladenosine (m6A) modification acts as the most prevalent internal modification in eukaryotic mRNA. Emerging evidence shows the critical biological roles of m6A key enzymes in human cancers.
Wenqing Gao (766108), Weiliang Song (11052375), Zili Zhang (324010), Junzhong Shi (12493369), Tong Li (206968), Yu Xing (311425), Liping Yang (156318)   +6 more
core   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, EarlyView.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source

In silico exploring of the epigenetic factors in teratozoospermia: A focus on IGF2BP2.

Molecular biology research communications
Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been implicated in the regulation of gene expression in teratozoospermia, but the specific mechanisms are not fully understood.
Mousavi, Seyedeh Zahra, MohammadSoltani, Bahram, Hadizadeh, Morteza, Rokhsattalab, Zeynab, Totonchi, Mehdi   +4 more
openaire   +3 more sources

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians [PDF]

Diabetes, 2008
OBJECTIVE—We performed a comprehensive genetic association study of common variation spanning the IGF2BP2 locus in order to replicate the association of the “confirmed” type 2 diabetes susceptibility variants rs4402960 and rs1470579 in the French Caucasian population and to further characterize the susceptibility variants at this novel locus.
Duesing, Konsta, Fatemifar, Ghazaleh, Charpentier, Guillaume, Marre, Michel, Tichet, Jean, Hercberg, Serge, Balkau, Beverley, Froguel, Philippe, Gibson, Fernando   +8 more
openaire   +2 more sources

Insulin-like growth factor-2 mRNA-binding protein 2 facilitates post-ischemic angiogenesis by increasing the stability of fibroblast growth factor 2 mRNA and its protein expression

Heliyon
Background: Post-ischemic angiogenesis is crucial for reestablishing blood flow in conditions such as peripheral artery disease (PAD). The role of insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2) in post-transcriptional RNA metabolism and ...
Shuai Ma, Yiqing Hu, Wangguo Xu, Weidong Xiong, Xinyu Xu, Yajie Hou, Ying Wang, Panke Chen, Wenbi Yang, Hao Lu, Yongchao Zhao   +10 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Pairwise linkage disequilibrium among IGF2BP2 SNPs in Malaysian subjects.

, 2012
Pairwise linkage disequilibrium among IGF2BP2 SNPs in Malaysian subjects.
Sekaran Muniandy (134168), Zaid Al-Hamodi (134163), Riyadh Saif-Ali (134160), Sameer D. Salem (134158), Ikram S. Ismail (134162), Rozaida Poh (134166)   +5 more
core   +1 more source