Results 61 to 70 of about 7,271 (197)

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer [PDF]

Molecular Cancer, 2019
Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target. Methods
Yun Wang, Jia-Huan Lu, Qi-Nian Wu, Ying Jin, De-Shen Wang, Yan-Xing Chen, Jia Liu, Xiao-Jing Luo, Qi Meng, Heng-Ying Pu, Ying-Nan Wang, Pei-Shan Hu, Ze-Xian Liu, Zhao-Lei Zeng, Qi Zhao, Rong Deng, Xiao-Feng Zhu, Huai-Qiang Ju, Rui-Hua Xu   +18 more
openaire   +3 more sources

IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation

Cancer Medicine, 2023
Background Pancreatic carcinoma (PC) is a highly lethal cancer with an increasing mortality rate, its five‐year survival rate is only approximately 4%. N6‐methyladenosine (m6A) modification is the most common posttranscriptional modification of RNA, it ...
Pei Cao, Yufan Wu, Ding Sun, Weigang Zhang, Junyi Qiu, Zuxiong Tang, Xiaofeng Xue, Lei Qin   +7 more
doaj   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

IGF2BP2‐induced circRNF20 facilitates breast cancer cell proliferation via the HuR/CDCA4 axis

Kaohsiung Journal of Medical Sciences
This study aimed to explore the mechanism of insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) affecting the proliferation of breast cancer (BC) cells.
Shu‐Tao Wu, Xiao‐Li Hou, Fei Wang, Wei Sun, Jia‐Jie Chen, Ya‐Sen Cao, Hong Cheng   +6 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification

, 2023
A growing number of studies have shown the prognostic importance of Cell division cycle protein 45 (CDC45) in hepatocellular carcinoma (HCC). This study aims to investigate the biological function and mechanism of CDC45 in HCC.
Qilin Yi (3634615), Li Liao (400021), Shuai Chen (506142), Min Xu (15203), Tao Wu (16763)   +4 more
core   +1 more source

METTL3-Mediated N6-Methyladenosine Ferroptosis in Sepsis-Associated Acute Lung Injury — A Narrative Review

Frontiers in Bioscience-Landmark
Sepsis-induced acute lung injury (ALI) represents a complex and life-threatening condition with limited therapeutic options. Recent research has unveiled the role of methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) modifications in ...
Rinki Kumari, Roger Leng, Brian Chiu, Consolato M. Sergi   +3 more
doaj   +1 more source

WTAP‐Mediated m6A Modification of TXNDC5 mRNA Promotes Cervical Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT WT1‐associated protein (WTAP), a core component of the methyltransferase complex, is involved in various tumor pathological processes, but its specific mechanism in cervical cancer (CC) remains unclear. This study, based on single‐cell transcriptomic data (including 3 CC and 2 normal tissues), constructed a CC microenvironment cell atlas ...
Ling Chen, Nuo‐Xin Hu, Zhao‐Ying Chen, Ke‐An Zhu, Wei Huang   +4 more
wiley   +1 more source

IGF2BP2 modulates autophagy and serves as a prognostic marker in glioma

Ibrain
AbstractGlioma, a malignant brain tumor originating from neural glial cells, presents significant treatment challenges. However, the underlying mechanisms of glioma development are not fully understood, and effective targets are lacking. This study provides insights into the role of insulin‐like growth factor 2 messenger RNA‐binding protein 2 (IGF2BP2)
Ning Li, Limei Deng, Yuming Zhang, Xilian Tang, Bingxi Lei, Qingyu Zhang   +5 more
openaire   +2 more sources

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source