Results 41 to 50 of about 7,271 (197)
Journal of Experimental & Clinical Cancer Research, 2019 Background The survival of pancreatic cancer patients remains poor. However, the underlying molecular mechanism and new therapeutic target of pancreatic cancer are still needed to be found.
Xiaodong Xu +4 more
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Journal of Inflammation Research, 2023 Pengxin Ge,1,* Huijie Duan,2,* Chunrong Tao,3,* Sensen Niu,4 Yiran Hu,5 Rui Duan,6 Aizong Shen,7 Yancai Sun,1 Wen Sun3 1Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences
Ge P +8 more
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Clinical Significance of an m6A Reader Gene, IGF2BP2, in Head and Neck Squamous Cell Carcinoma
Frontiers in Molecular Biosciences, 2020 The importance of N6-methyladenosine (m6A) in tumor recurrence and prognosis has been recognized in recent years. The role of m6A readers, such as insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), in regulating head and neck squamous cell ...
Xiaoli Deng +3 more
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CCN6 regulates IGF2BP2 and HMGA2 signaling in metaplastic carcinomas of the breast [PDF]
Breast Cancer Research and Treatment, 2018 Metaplastic breast carcinomas are an aggressive subtype of triple-negative breast cancer (TNBC) in which part or all of the adenocarcinoma transforms into a non-glandular component (e.g., spindled, squamous, or heterologous). We discovered that mammary-specific Ccn6/Wisp3 knockout mice develop mammary carcinomas with spindle and squamous ...
Emily R. McMullen +8 more
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IGF2BP2 Promotes Liver Cancer Growth Through an m6A-FEN1-Dependent Mechanism
Frontiers in Oncology, 2020 Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. N6−methyladenosine (m6A) plays an important role in posttranscriptional gene regulation. METTL3 and IGF2BP2 are key genes in the m6A signal pathway and have recently been
Jian Pu +11 more
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, 2019 Figure S6 related to Fig. 6: Clinical correlation between METTL3, SOX2 and IGF2BP2 in CRC. a, SOX2 and IGF2BP2 IHC staining scores in primary CRC tumor tissues (T) and adjacent normal tissue (ANT) (n = 432).
Zhan-Hong Chen (489922) +16 more
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Promotion of nonalcoholic steatohepatitis by RNA N6-methyladenosine reader IGF2BP2 in mice
Life Metabolism, 2022 AbstractNonalcoholic steatohepatitis (NASH) has emerged as the major cause of end-stage liver diseases. However, an incomplete understanding of its molecular mechanisms severely dampens the development of pharmacotherapies. In the present study, through systematic screening of genome-wide mRNA expression from three mouse models of hepatic inflammation ...
Bing Zhou +9 more
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Kaohsiung Journal of Medical Sciences, 2022 MicroRNA (miRNA) and long noncoding RNA (lncRNA) are both regulators of cancer progression. This study sought to discuss the functional mechanism of miR‐96‐5p/lncRNA TRIM52 antisense RNA 1 (head‐to‐head; TRIM52‐AS1) in cervical cancer (CC) cell ...
En Yuesu Wu +2 more
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, 2019 Figure S5 related to Fig. 5: IGF2BP2 enhances SOX2 mRNA stability via an m6A-dependent manner. a, Immunoblotting of IGF2BP1, IGF2BP3, YTHDF1, YTHDF2 after RNA pull down assay with cell lysate (Ly.), full-length biotinylated-SOX2 (FL), and beads only (NC)
Zhan-Hong Chen (489922) +16 more
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, 2022 N6-methyladenosine (m6A) regulators play an important role in multiple biological and pathological processes of radioiodine refractory papillary thyroid cancer (RR-PTC). However, the function of m6A regulators in differentiation of RR-PTC remains unclear.
Xian Qiu +5 more
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