Results 31 to 40 of about 7,271 (197)

IGF2BP2 Regulates MALAT1 by Serving as an N6-Methyladenosine Reader to Promote NSCLC Proliferation

Frontiers in Molecular Biosciences, 2022
Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is an important posttranscriptional regulatory for stability and m6A modification. Here, we investigated the role of IGF2BP2 in non–small-cell lung cancer (NSCLC) proliferation.
Le Han, Le Han, Guangyan Lei, Zhenghong Chen, Yili Zhang, Chen Huang, Wenjuan Chen   +6 more
doaj   +1 more source

Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease [PDF]

Aging, 2021
Alzheimer's disease, the most common form of dementia in the elderly, is a kind of neurodegenerative disease. However, its pathogenesis and diagnosis remain unclear. M6A is related to nervous system development and neurodegenerative diseases. Here in this study, using multiple RNA-seq datasets of Alzheimer's brain tissues, along with bioinformatic ...
Deng, Yanyao, Zhu, Hongwei, Xiao, Le, Liu, Chao, Liu, Ya-Lin, Gao, Wenzhe   +5 more
openaire   +2 more sources

LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis

Cell Death & Disease, 2022
AbstractLong non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro and in vivo. However, the underlying mechanism(s) of LCAT1 as an oncogenic regulator remains elusive.
Juze Yang, Xinyi Qian, Qiongzi Qiu, Lingling Xu, Meidie Pan, Jia Li, Jiayi Ren, Bingjian Lu, Ting Qiu, Enguo Chen, Kejing Ying, Honghe Zhang, Yan Lu, Pengyuan Liu   +13 more
openaire   +3 more sources

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Journal of Experimental & Clinical Cancer Research, 2022
Background Lymph node metastasis is the main cause of poor prognosis of head and neck squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is an emerging epigenetic regulatory mechanism for gene expression, and as a novel m6A ...
Dan Yu, Min Pan, Yanshi Li, Tao Lu, Zhihai Wang, Chuan Liu, Guohua Hu   +6 more
doaj   +1 more source

IGF2BP2 Promotes Esophageal Squamous-Cell Carcinoma Progression with Potential Involvement of PI3K/AKT Signaling. [PDF]

Curr Issues Mol Biol
Esophageal squamous-cell carcinoma (ESCC) remains a highly lethal malignancy, with long-term survival still unsatisfactory and an urgent need for clinically relevant molecular targets.
Gao X, Yang M, Yang J, Zhong Y, Ma C, Xu G, Zhang L, Zhang R.   +7 more
europepmc   +2 more sources

Let-7e-5p Regulates IGF2BP2, and Induces Muscle Atrophy [PDF]

Frontiers in Endocrinology, 2021
Background and AimsTo understand the role of microRNAs in muscle atrophy caused by androgen-depletion, we performed microarray analysis of microRNA expression in the skeletal muscles of Sham, orchiectomized (ORX), and androgen-treated ORX mice.MethodsTo clarify role and mechanisms of let-7e-5p in the muscle, the effect of let-7e-5p overexpression or ...
Takuro Okamura, Hiroshi Okada, Hiroshi Okada, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui   +10 more
openaire   +3 more sources

IGF2BP2 alternative variants associated with glutamic acid decarboxylase antibodies negative diabetes in Malaysian subjects. [PDF]

, 2012
BACKGROUND: The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations.
Sekaran Muniandy (134168), Zaid Al-Hamodi (134163), Riyadh Saif-Ali (134160), Sameer D. Salem (134158), Ikram S Ismail, Zaid Al-Hamodi, Rozaida Poh, Sameer D Salem, Ikram S. Ismail (134162), Sekaran Muniandy, Riyadh Saif-Ali, Rozaida Poh (134166)   +11 more
core   +4 more sources

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader [PDF]

Cell Death & Differentiation, 2019
AbstractThe major function of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is to regulate cell metabolism. However, emerging evidence indicates that IGF2BP2 plays a role in cancer, but the underlying mechanism is largely unknown. Here we showed that upregulation of IGF2BP2 is associated with poor outcomes of pancreatic cancer patients ...
Hu, Xiaoge, Peng, Wan-Xin, Zhou, Huaixiang, Jiang, Jiahong, Zhou, Xinchun, Huang, Dongsheng, Mo, Yin-Yuan, Yang, Liu   +7 more
openaire   +2 more sources

IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma [PDF]

Bioscience Reports, 2022
Abstract Aim: The main of the present study was to investigate the role of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) in oral squamous cell carcinoma (OSCC) with the overarching of providing new biomarkers or potential therapeutic targets for OSCC. Methods: We combined datasets downloaded from Gene
Xiangpu Wang, Haoyue Xu, Zuo Zhou, Siyuan Guo, Renji Chen   +4 more
openaire   +2 more sources

Inhibition of the m(6)A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia [PDF]

, 2022
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant leukemia with extremely limited treatment for relapsed patients. N6‐methyladenosine (m(6)A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) participates in the ...
Jingjing Ye, Li, Wei, Zhao, Baobing, Zhang, Yupeng, Ji, Chunyan, Xia Wang, Baobing Zhao, Wei Li, Chunyan Ji, Yupeng Zhang, Li, Yanxia, Feng, Panpan, Zhang, Jingru, Yanxia Li, Ye, Jingjing, Li, Jingxin, Dawei Chen, Boya Li, Li, Zhenyu, Panpan Feng, Chen, Dawei, Jingxin Li, Zhenyu Li, Wang, Xia, Li, Boya, Jingru Zhang   +25 more
core   +2 more sources