Results 21 to 30 of about 7,271 (197)

IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis [PDF]

Frontiers in Oncology
This study reveals the core mechanism by which insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) drives tumor progression and radiotherapy resistance in gastric cancer (GC) through m6A-dependent regulation of hypoxia-inducible factor 1α ...
Qi Zhang, Qi Zhang, Xiaoyu Liu, Yukan Chen, Ruilin Wang, Shuangyan Zhao, Yuting Tian, Shuping Li, Shuping Li, Shuping Li, Xiaojun Liu, Xiaojun Liu, Xiaojun Liu   +12 more
doaj   +2 more sources

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers [PDF]

Cancer Cell International, 2021
The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene.
Jinyan Wang, Lijuan Chen, Ping Qiang
doaj   +3 more sources

IGF2BP2 acts as a m6A modification regulator in laryngeal squamous cell carcinoma through facilitating CDK6 mRNA stabilization

Cell Death Discovery, 2023
Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly seen cancers in the head and neck region with increasing morbidity and mortality globally. N6-methyladenosine (m6A) modification plays a critical role in the carcinogenesis of LSCC.
Xiaojun Tang, Qinglai Tang, Shisheng Li, Mengmeng Li, Tao Yang   +4 more
doaj   +2 more sources

Small Extracellular Vesicles Promote HBV Replication via METTL3–IGF2BP2-Mediated m6A Modification

Frontiers in Bioscience-Landmark
Background: The roles of small extracellular vesicles (sEVs) and mRNA modifications in regulating hepatitis B virus (HBV) transmission, replication, and related disease progression have received considerable attention.
Jie Zhang, Ling Yu, Xinyu Wu, Wanlong Pan   +3 more
doaj   +2 more sources

IGF2BP2: an m6A reader that affects cellular function and disease progression

Cellular & Molecular Biology Letters
Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 (IGF2BP2) is a widely studied N6-methyladenosine (m6A) modification reader, primarily functioning to recognize and bind to m6A modification sites on the mRNA of downstream target genes ...
Siyi Liu, Shan Liao, Junyu He, Yanhong Zhou, Qian He   +4 more
doaj   +3 more sources

circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA

eLife, 2023
Circular RNAs represent a class of endogenous RNAs that regulate gene expression and influence cell biological decisions with implications for the pathogenesis of several diseases.
Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup, Morten Muhlig Nielsen, Anne Kruse Hollensen, Mette Laugesen Graversgaard, Matilde Helbo Sørensen, Lasse Sommer Kristensen, Søren Vang, Samuel S Park, Eugene Yeo, Lars Dyrskjøt, Jørgen Kjems, Jakob Skou Pedersen, Christian Kroun Damgaard   +13 more
doaj   +7 more sources

Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis

The Turkish Journal of Gastroenterology
Background/Aims: Ulcerative colitis (UC), an idiopathic and chronic inflammatory disease, primarily targets the mucosal lining of the colon. This research endeavors to reveal the mechanism of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2 ...
Ruifan Li, Bin Gu, Anli Lv
doaj   +3 more sources

Additional file 1 of FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer

Additional file 1: Supplementary Figure 1. IGF2BP2 is overexpressed in radioresistant lung cancer cells and promotes radioresistance in lung cancer, related to Figure 1. Supplementary Figure 2.
Chao Wan (309251), Kunyu Yang (15043166), Jingshu Meng (16022153), Zhiyuan Zhou (350818), Mengjie Che (12043676), Yue Deng (417668), Yijun Wang (321141), Xiao Yang (19898), Bin Zhang (64682), Zishan Feng (11720705), Yan Hu (30839), Lu Wen (385160), Yajie Sun (4404169), Fang Huang (154302), Jiacheng Wang (1359669), Yan Li (23143), Jie Li (15030), Wenwen Wei (8775398), Yuhan Sheng (17830460), Suke Deng (16022150)   +19 more
core   +2 more sources

KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research
Background Head and neck squamous carcinoma (HNSCC) is known for its high aggressiveness and susceptibility to cervical lymph node metastasis, which greatly contributes to its poor prognosis.
Hongshi Cai, Jianfeng Liang, Yaoqi Jiang, Ziyi Wang, Hongyu Li, Wenjin Wang, Cheng Wang, Jinsong Hou   +7 more
doaj   +2 more sources

IGF2BP2 promotes head and neck squamous carcinoma cell proliferation and growth via the miR-98-5p/PI3K/Akt signaling pathway

Frontiers in Oncology, 2023
IntroductionAs a N6-methyladenosine reader protein, Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a critical player in tumor progression and metastasis. However, its specific function in head and neck squamous carcinoma (HNSCC) has yet
Dan Yu, Zhenlong Xiao, Zhefei Zou, Ling Lin, Jing Li, Jian Tan, Wei Chen, Wei Chen, Wei Chen   +8 more
doaj   +1 more source