Results 11 to 20 of about 7,271 (197)

IGF2BP2 Overexpression Indicates Poor Survival in Patients with Acute Myelocytic Leukemia [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: IGF2BP2 has been reported to serve as an oncogene in various solid cancers. However, the role of IGF2BP2 in acute myelocytic leukemia (AML) is still unknown.
Xin He, Wenlu Li, Xiaogong Liang, Xuan Zhu, Lei Zhang, Yu Huang, Teng Yu, Shu Li, Zhigang Chen   +8 more
doaj   +5 more sources

FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer

Journal of Experimental & Clinical Cancer Research
Background The development of radioresistance seriously hinders the efficacy of radiotherapy in lung cancer. However, the underlying mechanisms by which radioresistance occurs are still incompletely understood.
Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen, Fang Huang, Yuhan Sheng, Chao Wan, Kunyu Yang   +19 more
doaj   +4 more sources

RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy [PDF]

Communications Biology, 2023
The IGF2BP family of RNA binding proteins consists of three paralogs that regulate intracellular RNA localization, RNA stability, and translational control.
Miriam Krumbein, Froma Oberman, Yuval Cinnamon, Mordechai Golomb, Dalit May, Gilad Vainer, Vitali Belzer, Karen Meir, Irina Fridman, Johannes Haybaeck, Gerhard Poelzl, Izhak Kehat, Ronen Beeri, Sonja M. Kessler, Joel K. Yisraeli   +14 more
doaj   +3 more sources

An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis [PDF]

Developmental Cell, 2012
SummaryA group of genes that are highly and specifically expressed in proliferating skeletal myoblasts during myogenesis was identified. Expression of one of these genes, Hmga2, increases coincident with satellite cell activation, and later its ...
Brack, Andrew S., Zhang, Minsi, Glass, David J., Campbell, Kevin P., Kirsch, David G., Li, Zhizhong, Ramanujan, Krishnan, Gilbert, Jason A., Eash, John K., Qiu, Qiong, Zhang, Yunyu, Goddeeris, Matthew M., Scaramozza, Annarita, Shavlakadze, Tea   +13 more
core   +5 more sources

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism

Biology Direct, 2023
Background Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this cancer type.
Tian-yue Liu, Chen-chen Hu, Chen-ying Han, Si-yi Mao, Wen-xin Zhang, Yi-ming Xu, Yuan-jie Sun, Dong-bo Jiang, Xi-yang Zhang, Jia-xing Zhang, Jing Wang, Xu-peng Qiao, Jing-yu Pan, Shu-ya Yang, Kun Yang   +14 more
doaj   +2 more sources

Airn Regulates Igf2bp2 Translation in Cardiomyocytes [PDF]

Circulation Research, 2018
Rationale: Increasing evidence indicates the presence of lncRNAs in various cell types.
Tyler Weirick, Sujith Dassanayaka, Mohammed Rabiul Hosen, Steven P. Jones, Stefanie Dimmeler, Shizuka Uchida, Giuseppe Militello, Yuliya Ponomareva, Marcin Wysoczynski, Joseph B. Moore, Claudia Döring   +10 more
core   +3 more sources

IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy

Journal of Diabetes and its Complications, 2012
Objective: The IGF2BP2 gene is located on chromosome 3q27.2 within a region linked to type 1 diabetes (T1D), type 2 diabetes (120) and diabetic nephropathy (ON). Its protein functionally binds to 5'-UTR of the imprinting IGF2 gene. The present study aims
Abu Seman, Norhashimah, Falhammar, Henrik, Brismar, Kerstin, Gu, Harvest F., Möllsten, Anna,, Horova, Eva, Prazny, Martin, Gu, Tianwei   +7 more
core   +3 more sources

An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

iScience, 2022
Summary: lncRAP2 is a conserved cytoplasmic lncRNA enriched in adipose tissue and required for adipogenesis. Using purification and in vivo interactome analyses, we show that lncRAP2 forms complexes with proteins that stabilize mRNAs and modulate ...
Juan R. Alvarez-Dominguez, Sally Winther, Jacob B. Hansen, Harvey F. Lodish, Marko Knoll   +4 more
doaj   +2 more sources

IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

Cell Reports
Summary: Ovarian cancer (OC) is the most lethal gynecological malignancy, and high expression of IGF2BP2 is significantly associated with poor prognosis.
Xueyou Xiong, Xuan Wang, Zhenlong Wang, Feixue Chen, Yaqian Shi, Xiyi Chen, Weijian Gong, Xuemei Jia, Juan Xu   +8 more
doaj   +2 more sources

ADAM32 Oncogene in Hepatoblastoma Is Regulated by IGF2BP2

Cancers
Background/Objectives: The membrane protein a disintegrin and metalloproteases (ADAMs) are highly expressed in various human carcinomas and play an important role in cancer characteristics.
Keiji Tanimoto, Masami Kanawa, Takahiro Fukazawa, Masato Kojima, Eiso Hiyama, Nobuyuki Hirohashi   +5 more
core   +3 more sources