Results 1 to 10 of about 24,598,426 (162)

Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients [PDF]

Biomedicines, 2023
Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%; therefore, non-invasive biomarkers such as measurable circulating proteins for early detection and prognosis are crucial.
Maryam H. Alrashid, Ahmad E. Al-Serri, Rubina F. Hussain, Suzanne A. Al-Bustan, Jasem Al-Barrak   +4 more
doaj   +2 more sources

The impact of circulating IGF-1 and IGFBP-2 on cardiovascular prognosis in patients with acute coronary syndrome [PDF]

Frontiers in Cardiovascular Medicine, 2023
BackgroundWhile insulin-like growth factor 1 (IGF-1) exerts a cardioprotective effect in the setting of atherosclerosis, insulin-like growth factor binding protein 2 (IGFBP-2) is involved in metabolic syndrome.
Wei Wang, Wei Wang, Kang Yu, Shou-Yong Zhao, De-Gang Mo, Jia-Hui Liu, Li-Jinn Han, Tai Li, Heng-Chen Yao, Heng-Chen Yao   +9 more
doaj   +2 more sources

Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity [PDF]

Frontiers in Endocrinology, 2023
Lay summaryObesity is frequently accompanied by a fatty liver. However, some individuals with high abdominal fat levels nevertheless have low levels of liver fat. Reasons for such discordant phenotypes are unclear.
Chloé Rauzier, Chloé Rauzier, Dominic J. Chartrand, Dominic J. Chartrand, Natalie Alméras, Natalie Alméras, Isabelle Lemieux, Eric Larose, Eric Larose, Patrick Mathieu, Patrick Mathieu, Philippe Pibarot, Philippe Pibarot, Benoît Lamarche, Benoît Lamarche, Caroline Rhéaume, Caroline Rhéaume, Caroline Rhéaume, Paul Poirier, Paul Poirier, Jean-Pierre Després, Jean-Pierre Després, Jean-Pierre Després, Frédéric Picard, Frédéric Picard   +24 more
doaj   +2 more sources

Circulating IGFBP-2 levels are inversely associated with the incidence of nonalcoholic fatty liver disease: A cohort study [PDF]

Journal of International Medical Research, 2020
Objective The insulin-like growth factor (IGF) axis is essential for the body’s metabolism. The hepatokine, insulin-like growth factor-binding protein 2 (IGFBP-2), acts as a major regulator of this metabolism. We aimed to evaluate the role of serum IGFBP-
Ji Yang, Wenjing Zhou, Yue Wu, Liqian Xu, Yuming Wang, Zherong Xu, Yunmei Yang   +6 more
doaj   +2 more sources

IGFBP-2 in Critical Illness: A Prognostic Marker in the Growth Hormone/Insulin-like Growth Factor Axis [PDF]

Pathophysiology
Critical illness (CI) triggers complex disruptions in the growth hormone (GH)/insulin-like growth factor (IGF) axis, significantly affecting the dynamics of insulin-like growth-factor-binding proteins (IGFBPs).
Christos Savvidis, Eleni Kouroglou, Efthymia Kallistrou, Dimitra Ragia, Sofia Dionysopoulou, Georgios Gavriiloglou, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias   +9 more
doaj   +2 more sources

Effects of Lacticaseibacillus rhamnosus HA-114 probiotic supplementation on circulating IGFBP-2 levels during a calorie-restricted diet in overweight humans [PDF]

Journal of Clinical & Translational Endocrinology
Background and aim: Gut microbiota influences energy homeostasis in part through circulating hormones. Insulin-like growth factor-binding protein (IGFBP)-2 is a biomarker whose increase in systemic circulation is associated with positive effects on body ...
Justine Faramia, Béatrice S.-Y. Choi, Lucie Brunelle, André Marette, Vicky Drapeau, Angelo Tremblay, Frédéric Picard   +6 more
doaj   +2 more sources

Characterization of a novel IGFBP-2 transcript in the ovarian granulosa cells of chicken follicles: mRNA expression, function and effect of reproductive hormones and IGF1 [PDF]

Poultry Science
Insulin-like growth factor binding protein-2 (IGFBP-2), a binding protein of insulin-like growth factor (IGF) system, regulates the activity of IGFs and also influences cellular function with endogenous activity. In mammals, IGFBP-2 is reported to affect
Longxiao Hu, Dandan Li, Qingqing Wei, Li Kang, Yi Sun, Yunliang Jiang   +5 more
doaj   +2 more sources

IGFBP-2 Signaling in the Brain: From Brain Development to Higher Order Brain Functions [PDF]

Frontiers in Endocrinology, 2019
Insulin-like growth factor-binding protein-2 (IGFBP-2) is a pleiotropic polypeptide that functions as autocrine and/or paracrine growth factors. IGFBP-2 is the most abundant of the IGFBPs in the cerebrospinal fluid (CSF), and developing brain showed the ...
Shumsuzzaman Khan
doaj   +2 more sources

Circulating IGFBP‐2: a novel biomarker for incident dementia [PDF]

Annals of Clinical and Translational Neurology, 2019
Objective To determine the association between plasma insulin‐like growth factor binding protein 2 (IGFBP‐2) and cognitive outcomes. Methods We measured plasma IGFBP‐2 levels in 1596 (53% women, mean age 68.7 [SD 5.7] years) dementia‐free Framingham ...
Emer R. McGrath, Jayandra J. Himali, Daniel Levy, Sarah C. Conner, Charles S. DeCarli, Matthew P. Pase, Paul Courchesne, Claudia L. Satizabal, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri   +10 more
doaj   +2 more sources

Plasma Insulin-like Growth Factor-Binding Protein-2 of Critically Ill Patients Is Related to Disease Severity and Survival

Biomedicines, 2023
Insulin-like growth factor-binding protein (IGFBP)-2 regulates the bioactivity of the anabolic hormone’s insulin-like growth factors, which are decreased in sepsis and contribute to the catabolic status of severely ill patients. The circulating levels of
Patricia Mester, Ulrich Räth, Luisa Popp, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel   +6 more
doaj   +1 more source