Results 111 to 120 of about 1,067,036 (373)

MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder

Frontiers in Neurology, 2018
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from
G. D. dos Passos, L. Oliveira, Bruna Klein da Costa, S. Apóstolos-Pereira, D. Callegaro, K. Fujihara, D. Sato   +6 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

London to the south. Scenes of Argentine reading around an American author

Estudios de Teoría Literaria, 2016
The article opens with a critical review of Pierre Bourdieu’s proposal for the study of international exchanges regarding culture. After discussing the problematic aspects of his notion of “misunderstanding”, it puts forth an analysis of two argentine ...
Agustín Molina y Vedia
doaj  

IgG Fc engineering to modulate antibody effector functions

Protein & Cell, 2017
Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions.
Xinhua Wang, M. Mathieu, Randall J. Brezski   +2 more
semanticscholar   +1 more source

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions [PDF]

Journal of Allergy and Clinical Immunology, 2018
In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.
Epp, A., Hobusch, J., Bartsch, Y.C., Petry, J., Lilienthal, G.M., Koeleman, C.A.M., Eschweiler, S., Mobs, C., Hall, A., Morris, S.C., Braumann, D., Engellenner, C., Bitterling, J., Rahmoller, J., Leliavski, A., Thurmann, R., Collin, M., Moremen, K.W., Strait, R.T., Blanchard, V., Petersen, A., Gemoll, T., Habermann, J.K., Petersen, F., Nandy, A., Kahlert, H., Hertl, M., Wuhrer, M., Pfutzner, W., Jappe, U., Finkelman, F.D., Ehlers, M.   +31 more
openaire   +4 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A paper-based multiplexed serological test to monitor immunity against SARS-CoV-2 using machine learning [PDF]

ACS Nano (2024)
The rapid spread of SARS-CoV-2 caused the COVID-19 pandemic and accelerated vaccine development to prevent the spread of the virus and control the disease. Given the sustained high infectivity and evolution of SARS-CoV-2, there is an ongoing interest in developing COVID-19 serology tests to monitor population-level immunity.
arxiv   +1 more source

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin

Journal of Neuroinflammation, 2016
BackgroundAntibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders.ObjectiveTo assess (i) the frequency of MOG-IgG in a large and predominantly ...
S. Jarius, K. Ruprecht, I. Kleiter, N. Borisow, N. Asgari, K. Pitarokoili, F. Pache, O. Stich, L. Beume, M. W. Hümmert, C. Trebst, M. Ringelstein, O. Aktas, A. Winkelmann, M. Buttmann, Alexander Schwarz, H. Zimmermann, A. Brandt, D. Franciotta, M. Capobianco, J. Kuchling, J. Haas, Mirjam Korporal-Kuhnke, S. Lillevang, K. Fechner, Kathrin Schanda, F. Paul, B. Wildemann, M. Reindl   +28 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Elevated SARS-Cov-2-Specific IgM Levels Indicate Clinically Unfavorable Outcomes in Patients with COVID-19: A Retrospective Cohort Study

International Journal of General Medicine, 2021
Zhiquan Hu,1,* Jingjing Li,2,* Chunguang Yang,1 Fen Chen,3 Zhihua Wang,1 Ping Lei,4 Guanxin Shen4 1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China ...
Hu Z, Li J, Yang C, Chen F, Wang Z, Lei P, Shen G   +6 more
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