Results 71 to 80 of about 1,416,853 (336)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Immunodepletion in xenotransplantation [PDF]

, 1990
Xenograft transplantation is perhaps the most immunologically difficult problem in transplantation today. An overwhelming hyperacute rejection reaction (HAR) occurs within minutes of organ implantation.
A. Casavilla, A. G. Tzakis, A. Oks, A. Oral, B. Banner, Branda R F, Forsgren A, Giles G R, J. Murray, K. Yanaga, L. Makowka, L. Podesta, Langone J J, P. D'andrea, R. Shapiro, R. Watt, S. Wos, T. E. Starzl, Ting A, V. Scantlebury   +19 more
core   +1 more source

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions [PDF]

Journal of Allergy and Clinical Immunology, 2018
In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.
Epp, A., Hobusch, J., Bartsch, Y.C., Petry, J., Lilienthal, G.M., Koeleman, C.A.M., Eschweiler, S., Mobs, C., Hall, A., Morris, S.C., Braumann, D., Engellenner, C., Bitterling, J., Rahmoller, J., Leliavski, A., Thurmann, R., Collin, M., Moremen, K.W., Strait, R.T., Blanchard, V., Petersen, A., Gemoll, T., Habermann, J.K., Petersen, F., Nandy, A., Kahlert, H., Hertl, M., Wuhrer, M., Pfutzner, W., Jappe, U., Finkelman, F.D., Ehlers, M.   +31 more
openaire   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Estimating daily semantic segmentation maps of classified ocean eddies using sea level anomaly data from along-track altimetry

Frontiers in Artificial Intelligence
Mesoscale eddies, which are fast-moving rotating water bodies in the ocean with horizontal scales ranging from 10 km to 100 km and above, are considered to be the weather of the oceans.
Eike Bolmer, Adili Abulaitijiang, Jürgen Kusche, Ribana Roscher, Ribana Roscher   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

OncoImmunology, 2021
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies.
Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis, Philip J. Blower   +15 more
doaj   +1 more source

Influence of sow dietary polyunsaturated fatty acid source on the immunoglobulin profile of piglets [PDF]

, 2010
To examine the effect of different n-3 polyunsaturated fatty acid (PUFA) sources in sow diets on piglets’ immunoglobulin (Ig) profile, two groups of twelve sows each were fed different diets from day 45 of pregnancy and during lactation on two commercial
Cox, Eric, De Smet, Stefaan, Goddeeris, Bruno, Missotten, Joris, Raes, K, Tanghe, Sofie   +5 more
core  

Pathogenicity of anti-ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. [PDF]

, 2015
BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease in which anti-ADAMTS13 autoantibodies cause severe enzyme deficiency.
Crawley, JT, De Groot, R, Scully, MA, Thomas, MR   +3 more
core   +2 more sources

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs [PDF]

The Journal of Immunology, 2003
Abstract Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t1/2 compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions.
Roopenian, D C, Christianson, G J, Sproule, T J, Brown, A C, Akilesh, S, Jung, N, Petkova, S, Avanessian, L, Choi, E Y, Shaffer, D J, Eden, P A, Anderson, C L   +11 more
openaire   +2 more sources