Results 81 to 90 of about 1,416,853 (336)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Imperative of Co-existence

Technophany
In this article I examine the problem of technique in Georges Bataille's social ontology by means of a counterpoint with Bernard Stiegler's philosophy. I will defend the following theses: 1.
Tomás Ramos Mejía
doaj   +1 more source

Serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB) changes in elderly hip fracture patients after surgery and nutritional support [PDF]

Journal of Medical Biochemistry
Background: This study aimed to evaluate the effects of nutritional support combined with stratified nursing under delirium risk assessment on immune function and postoperative delirium in elderly hip fracture patients.
Jin Fangqin, Zhang Qin, Weng Jiangping, Pan Xuting, Dong Qinyan, Zhao Yuping   +5 more
doaj   +1 more source

Serodiagnosis of infectious mononucleosis by using recombinant Epstein-Barr virus antigens and enzyme-linked immunosorbent assay technology [PDF]

, 1990
Four recombinant, diagnostically useful Epstein-Barr virus (EBV) proteins representative of the viral capsid antigen (p150), diffuse early antigen (p54), the major DNA-binding protein (p138), and the EBV nuclear antigen (p72) (W. Hinderer, H.
Gorgievski-Hrisoho, M., Hinderer, W., Horn, J., Nebel-Schickel, H., Siegl, G., Sonneborn, H. H., Vornhagen, R., Wolf, Hans J.   +7 more
core   +1 more source

Possible role of TORCH agents in congenital malformations in Gorgan, northern Islamic Republic of Iran [PDF]

, 2009
This descriptive, cross-sectional study was carried out to explore the frequency of contamination with TORCH agents in neonates with congenital malformations in a referral centre in Gorgan city, Islamic Republic of Iran.
Ghaemi, E., Golalipour, M.J., Khodabakhshi, B.   +2 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

London to the south. Scenes of Argentine reading around an American author

Estudios de Teoría Literaria, 2016
The article opens with a critical review of Pierre Bourdieu’s proposal for the study of international exchanges regarding culture. After discussing the problematic aspects of his notion of “misunderstanding”, it puts forth an analysis of two argentine ...
Agustín Molina y Vedia
doaj  

Immunoblot analysis of the seroreactivity to recombinant Borrelia burgdorferi sensu lato antigens, including VlsE, in the long-term course of treated patients with Erythema migrans [PDF]

, 2008
Objective: We evaluated whether immunoblotting is capable of substantiating the posttreatment clinical assessment of patients with erythema migrans ( EM), the hallmark of early Lyme borreliosis.
Aguero-Rosenfeld ME, Aguero-Rosenfeld ME, Aguero-Rosenfeld ME, Bacon RM, Bettina Wilske, Bono JL, Bruckbauer HR, Christina Ambros-Rudolph, Coleman JL, Dressler F, Engstrom SM, Feder, Fung BP, Glatz M, Goettner G, Grodzicki RL, Guo BP, Hansen K, Hauser U, Helmut Kerl, Hofmann H, Hulshof MM, Jauris-Heipke S, Kalish RA, Lahdenne P, Lebech AM, Ledue TB, Liang FT, Liang FT, Magnarelli LA, Magnarelli LA, Marangoni A, Martin Glatz, Massarotti EM, Mullegger RR, Peltomaa M, Philipp MT, Picken MM, Plorer A, Rasiah C, Robert R. Müllegger, Roessler D, Ruzic-Sabljic E, Ryffel K, Shadick NA, Sillanpaa H, Simpson WJ, Smith RP, Stanek G, Stanek G, Volker Fingerle, Volkman DJ, Wilske B, Wilske B, Wilske B, Wilske B, Wormser GP, Zhang JR   +57 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Bernardo Mançano Fernandes y el territorio como proceso espacial de construcción política.

Finisterra - Revista Portuguesa de Geografia, 2021
El territorio es un concepto de origen geográfico con más de un siglo de historia y desde hace varias décadas ha cobrado una notoria visibilidad en las Ciencias Sociales de Europa, Norteamérica y América Latina.
Guillermo Castillo Ramírez
doaj