Results 11 to 20 of about 264,380 (213)
SCCA1–IGM and SCCA2–IGM Compared with Total SCCA-IGM for Diagnosis of Hepatocellular Carcinoma
The International Journal of Biological Markers, 2009 Introduction SCCA1 and SCCA2 belong to the family of serine protease inhibitors (SERPIN). Both SCCA isoforms have been found to be increased in patients with squamous cell carcinoma (SCC) of different organs. Recent findings have demonstrated that SCCA-IgM immune complexes are a novel class of biomarkers for ...
BIASIOLO, ALESSANDRA +6 more
openaire +3 more sources
, 2023 Introduction Waldenström macroglobulinemia (WM) represents a subset of lymphoplasmacytic lymphoma (LPL) with the immunoglobulin (Ig)M paraprotein. MYD88 L265P and CXCR4 mutations are common mutations in WM patients, and mutations in ARID1A and KMT2D ...
Kasamatsu T. (14788534) +10 more
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Serological survey of anti-group A rotavirus IgM in UK adults [PDF]
, 2003 Rotaviral associated disease of infants in the UK is seasonal and infection in adults not uncommon but the relationship between these has been little explored.
Cox, M. J., Medley, Graham
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Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]
, 2004 86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M. +5 more
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Effect of LUX and IB on anti-IgM-induced phosphorylation of LYN in SU-DHL-6 cells.
, 2023 Cells were pre-treated with vehicle or 1 μM LUX or IB after which they were stimulated with anti-human IgM. LYN immunoprecipitates from these cells were analyzed using antibodies for phospho-Src (Y416) and LYN at the indicated time points in SU-DHL-6 ...
Stephen B. Howell (424989) +2 more
core +1 more source
Structure, Function, and Therapeutic Use of IgM Antibodies
Antibodies, 2020 Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to ...
Bruce A. Keyt +4 more
doaj +1 more source
IgM-Associated Cryoglobulinaemia
Hemato, 2023 Cryoglobulinaemia is characterised by serum immunoglobulins that precipitate at temperatures below 37 °C and redissolve on warming. Monoclonal IgM immunoglobulin can be associated with type I and II cryoglobulinaemia with underlying Waldenström macroglobulinemia, monoclonal gammopathy of undetermined significance, or another non-Hodgkin lymphoma.
Jahanzaib Khwaja +2 more
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, 2020 BACKGROUND: Scrub typhus is an acute febrile illness caused by the obligate intracellular bacterium, Orientia tsutsugamushi. Immunochromatography (ICT) and IgM ELISA are two of the routinely employed antibody based assays for diagnosis of Scrub typhus ...
Parajuli, Keshab +4 more
core +1 more source
Mechanism of IgM Polymerization [PDF]
Proceedings of the National Academy of Sciences, 1974 The stoichiometry of J chain in pentamer IgM has been determined by measuring the radiolabeled thiols in the constituent chains after complete reduction and alkylation of the polymer. One mole of J was found to be disulfide bonded to 1 mol of pentamer.
R M, Chapuis, M E, Koshland
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Journal of Experimental Medicine, 2018 In this issue of JEM, Thierry et al. (https://doi.org/10.1084/jem.20180344) demonstrate that, once secreted by freshly activated plasmablasts, IgM leaves the lymph node via the microarchitecture of the fibroblastic reticular cell conduit. This work demonstrates how the very peculiar stromal compartment of lymphatic organs optimizes the systemic ...
Anne Reversat, Michael Sixt
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