Results 31 to 40 of about 427,117 (288)

Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress

Biomolecules, 2022
Oxidative stress plays a central role in the pathophysiology of melanoma. Curcumin (CUR) is a polyphenolic phytochemical that stimulates reactive oxygen species (ROS) production, while disulfiram (DSS) is a US FDA-approved drug for the treatment of ...
Sheila S. Fontes, Mateus L. Nogueira, Rosane B. Dias, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Marcos A. Vannier-Santos, Daniel P. Bezerra   +6 more
doaj   +1 more source

Feedback and its Feedback Effect on Feedback: Photoionization Suppression and its Impact on Galactic Outflows [PDF]

, 2007
We show that radiative feedback due to reionization has a pronounced effect on the extent of mechanical feedback due to galactic outflows. The photoionization of the Intergalactic Medium (IGM) suppresses low-mass galaxy formation by photoheating the gas ...
Martel, Hugo, Pieri, Matthew M.
core   +2 more sources

The role of IgG avidity in diagnosis of cytomegalovirus infection in newborns and infants [Uloga IgG aviditeta u dijagnostici infekcije citomegalovirusom u novorođenčadi i dojenčadi] [PDF]

, 2012
To evaluate the value of IgG avidity in diagnosis of congenital cytomegalovirus (CMV) infection in newborns and infants we collected serum samples from 40 infants under 12 months of age with suspected congenital CMV infection.
Ljubin-Sternak, Sunčanica, Mlinarić-Galinović, Gordana, Sviben, Mario, Vilibić-Čavlek, Tatjana, Vojnović, Gordana   +4 more
core  

Cosmology-independent Estimate of the Fraction of Baryon Mass in the IGM from Fast Radio Burst Observations

, 2019
The excessive dispersion measure (DM) of fast radio bursts (FRBs) has been proposed to be a powerful tool to study intergalactic medium (IGM) and to perform cosmography.
Gao, He, Li, Zhengxiang, Wei, Jun-Jie, Yang, Yuan-Pei, Zhang, Bing, Zhu, Zong-Hong   +5 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.

Frontiers in Genetics, 2015
DNA replication and transcription are vital cellular processes during which the genetic information is copied into complementary DNA and RNA molecules.
Alessandra eBrambati, Arianna eColosio, Luca eZardoni, Lorenzo eGalanti, Giordano eLiberi, Giordano eLiberi   +5 more
doaj   +1 more source

P- 81 PREVALENCE OF HEV INFECTION IN HIV CARRIERS, PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND CIRRHOTIC PATIENTS

Annals of Hepatology, 2023
Introduction and Objectives: Hepatitis E is a neglected disease in Brazil. Hepatitis E virus (HEV) can cause chronic illness in immunocompromised patients.
Luan Henrique Paim Santos, Luíza Araújo de Santana Cavalcanti, Daniela Santana Mendes, Victoria Cruz Paraná, Júlia Stifelman Freire Alves, Fernanda Souza Novais, Sidelcina Rugieri Pacheco, Maria Alice Sant'Anna Zarife, Hermes Pedreira da Silva Filho, Carina Carvalho dos Santos, Ricardo David Couto, Marina Pamponet Motta, Carlos Roberto Brites Alves, Maria Isabel Schinoni, André Castro Lyra, Mitermayer Galvão dos Reis, Luciano Kalabric Silva   +16 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

Emerging Microbes and Infections, 2023
The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains.
Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu   +27 more
doaj   +1 more source

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source