Results 81 to 90 of about 427,117 (288)
Advanced Science, EarlyView.BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou +9 more
wiley +1 more source
Toxoplasmosis in thalassemic Iraqi patients: serological and hematological study [PDF]
Romanian Journal of Infectious DiseasesBackground. Toxoplasmosis is a zoonotic parasitic disease with high prevalence, caused by an obligate intracellular parasite Toxoplasma gondii. Thalassemia is an inherited blood disorder in which the body makes an atypical form or insufficient amount of ...
Raghad N. Shihab, Israa Kasim Al-Aubaidi
doaj +1 more source
Unveiling the nature of dark matter with high redshift 21 cm line experiments
, 2014 Observations of the redshifted 21 cm line from neutral hydrogen will open a new window on the early Universe. By influencing the thermal and ionization history of the intergalactic medium (IGM), annihilating dark matter (DM) can leave a detectable ...
Evoli, Carmelo +2 more
core +1 more source
Advanced Science, EarlyView.Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang +10 more
wiley +1 more source
EARLY DETECTION AND EPIDEMIOLOGICAL PROFILE OF OROPOUCHE FEVER IN SALVADOR-BA
Brazilian Journal of Infectious DiseasesIntroduction/Objectives: Oropouche fever, caused by the Oropouche virus (OROV), is an arboviral disease with sylvatic and urban cycles endemic to the Amazon region. Transmission occurs through the biting midge Culicoides paraensis. Symptoms include fever,
Adryele Figueiredo Pinheiro +9 more
doaj +1 more source
Self-Consistent Modeling of Reionization in Cosmological Hydrodynamical Simulations
, 2017 The ultraviolet background (UVB) emitted by quasars and galaxies governs the ionization and thermal state of the intergalactic medium (IGM), regulates the formation of high-redshift galaxies, and is thus a key quantity for modeling cosmic reionization ...
Hennawi, Joseph F +2 more
core +1 more source
AGN Feedback Causes Downsizing [PDF]
, 2005 We study the impact of outflows driven by active galactic nuclei (AGN) on galaxy formation. Outflows move into the surrounding intergalactic medium (IGM) and heat it sufficiently to prevent it from condensing onto galaxies.
Evan Scannapieco +6 more
core +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Intermittence of the Map of Kinetic Sunyaev-Zel'dovich Effect and Turbulence of IGM
, 2011 We investigate the possibility of detecting the turbulent state of the IGM with the kinetic Sunyaev-Zel'dovich (kSZ) effect. Being sensitive to the divergence-free component of the momentum field of the IGM, the kSZ effect might be used to probe the ...
Atrio-Barandela +14 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai +6 more
wiley +1 more source