Results 151 to 160 of about 1,105,003 (199)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

IL-33-mediated mast cell and eosinophil function requires isoprenylation. [PDF]

Front Immunol
Burchett JR, Kotha A, Davis DT, Jackson KG, Dailey JM, Maldonado TD, Haque TT, Hussain ZY, Ching JM, Frischmeyer-Guerrerio P, Sebti SM, Ryan JJ.   +11 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Role of Serum IL-33 in <i>Bothrops</i> Snakebite Victims: Linking Inflammation and Endothelial Dysfunction. [PDF]

Toxins (Basel)
Lopes NC, Santos RSS, Meneses GC, Araújo LM, Martins BVB, Araújo KMDR, Feitosa MC, Varela YP, Shihana F, Mota SMB, da Silva Junior GB, Daher EF, Albuquerque PLMM, Martins AMC.   +13 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Expression Analysis of JCAD and IL-33 in Gingival Cancer Tumor Angiogenesis. [PDF]

Cancers (Basel)
Shirai T, Kakei Y, Muraki Y, Nagano T, Suraya R, Uryu K, Takeda D, Shigeoka M, Kimoto A, Hasegawa T, Hara T, Emoto N, Akashi M.   +12 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis. [PDF]

Nat Commun
Zhang L, Gui X, Hou R, Jia L, Xia S, Zhang X, Fu Y, Meng QF, Luo Q, Shi X, Guo B, Liang R, Yue L, Chen X, Xu H, Wang P, Tong X, Liu L, Wang L, Li B, Chen Z, Zhou L, Zhang L, Chen R, Sun C, Xu W, Rao L, Zhou H, Ding BS, Chen S.   +29 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy. [PDF]

MAbs
Chen J, Wang Y, Wang X.
europepmc   +1 more source