Results 61 to 70 of about 1,096,946 (288)
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
NatureTertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR)
M. Amisaki +35 more
semanticscholar +1 more source
Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance ...
H. Hong +4 more
semanticscholar +1 more source
IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells
Frontiers in Endocrinology, 2019 Interleukin-33 (IL-33), a member of the IL-1 superfamily, has been shown to play a critical role in many diseases through regulating the immune cell responses, including myeloid-derived suppressor cells (MDSCs). Our previous study demonstrated that IL-33
Ke Shang +9 more
doaj +1 more source
IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential
Frontiers in ImmunologyInterleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form ...
Feiya Sheng +6 more
semanticscholar +1 more source
IL‐33/ST2 as a potential target for tumor immunotherapy
European Journal of Immunology, 2021 IL‐33, a member of the IL‐1 family, was initially reported to be expressed constitutively in the nucleus of tissue‐lining and structural cells. However, upon tissue damage or injury, IL‐33 can be released quickly to bind with its cognate receptor ST2 in ...
Wenyi Jiang +3 more
semanticscholar +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Preeclampsia (PE) is a systemic inflammatory response syndrome involving varieties of cytokines, and previous studies have shown that IL-33 and its receptor IL-1RL1 play pivotal roles in the development of it. As a polygenetic hereditary
Xiaoyan Ren +8 more
doaj +1 more source
Macrophages reprogramming improves immunotherapy of IL-33 in peritoneal metastasis of gastric cancer
EMBO Molecular MedicinePeritoneal metastasis (PM) has a suppressive tumor immune microenvironment (TIME) that limits the effects of immunotherapy. This study aimed to investigate the immunomodulatory effects of intraperitoneal administration of IL-33, a cytokine that is ...
Keying Che +11 more
semanticscholar +1 more source
Journal of Inflammation Research, 2022 Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL +13 more
doaj
Diagnostics, 2023 Interleukins are considered to be potential therapeutic targets that can alter the prognosis and disease progression of IBD. IL-21 has proven to be involved in effector Th1, Th2 and Th17 responses.
Alexandros Toskas +5 more
doaj +1 more source
Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye [PDF]
, 2016 Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization.
Allakhverdi +47 more
core +3 more sources