Results 61 to 70 of about 80,108,489 (239)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Come cambierà il dispositivo europeo antiriciclaggio alla luce del recentissimo Action Plan lanciato dalla Commissione?

, 2020
1. Abstract Il 7 maggio 2020, il Vice Presidente Esecutivo della Commissione Europea Valdis Dombrovskis, in occasione della presentazione del Piano di Azione contro il riciclaggio e il finanziamento del terrorismo, ha dichiarato «Dobbiamo porre fine ...
Marco Letizi
core  

Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. [PDF]

PLoS ONE, 2012
Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis.
Shabnam Shalapour, Katrin Deiser, Anja A Kühl, Rainer Glauben, Susanne M Krug, André Fischer, Ozen Sercan, Stephane Chappaz, Stefan Bereswill, Markus M Heimesaat, Christoph Loddenkemper, Michael Fromm, Daniela Finke, Günter J Hämmerling, Bernd Arnold, Britta Siegmund, Thomas Schüler   +16 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Immunological changes associated with post-surgical gram-negative bacterial infections

Babcock University Medical Journal
Objective: Post-surgical bacterial infections provoke immune responses mediated by various cytokines. This study aimed to assess immunological changes by measuring serum levels of IL-2, IL-7, IL-10, and IL-17 in post-surgical patients with bacterial ...
Massar Dohan, Ebtesam Jeaz , Azhar Hussein   +2 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours [PDF]

, 2003
Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by
Al-Rawi, M. A. A., Mansel, R.E., Jiang, W.G., Mansel, R. E., Jiang, Wen Guo, Al-Rawi, M.A.A.   +5 more
core  

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

IL-7-induced proliferation is not impaired while production of Bcl-2 is reduced in blood-derived CD8⁺ T-cells from HCV⁺ individuals.

, 2016
Cell proliferation in response to IL-7 (10ng/ml) and/or PHA (0.2mg/ml) was measured as CFSE dilution of CD8+ T-cells from (A) HCV- (n = 8) and (B) HCV+ individuals (n = 8), with markers indicating the proportion (%) of CFSElow (dividing) cells.
Angela M. Crawley (371040), Lorna Carrasco-Medina (2836493), Curtis L. Cooper (2836490), Stephanie C. Burke Schinkel (2836496)   +3 more
core   +1 more source