Results 101 to 110 of about 2,610,317 (379)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β.

PLoS Biology
Acute gastrointestinal infection with intracellular pathogens like Salmonella Typhimurium triggers the release of the proinflammatory cytokine interleukin 1β (IL-1β).
Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E Winter, Ron N Apte, Elena Voronov, Shai Bel   +21 more
doaj   +1 more source

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells [PDF]

, 2018
Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Grau, Veronika, Koch, Christian, Magel, Ilona, McIntosh, J. Michael, Padberg, Winfried, Perniss, Alexander, Richter, Katrin, Sander, Michael, Schweda, Elke K. H., Wichmann, Sven, Wilker, Sigrid, Wolf, Philipp M.   +11 more
core   +1 more source

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

Nature Communications, 2018
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined.
Themistoklis M. Tsarouchas, Daniel Wehner, L. Cavone, Tahimina Munir, Marcus Keatinge, Marvin Lambertus, Anna Underhill, T. Barrett, Elias Kassapis, Nikolay V. Ogryzko, Yi Feng, T. V. van Ham, T. Becker, C. G. Becker   +13 more
semanticscholar   +1 more source

Additional file 2: Table S1. of IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

, 2018
Commercially available primer sequences for genes analysed with RT-qPCR. (DOCX 13 kb)
Persson, Irma Mahmutovic, Menzel, Mandy, Sangeetha Ramu, Cerps, Samuel, Akbarshahi, Hamid, Uller, Lena   +5 more
openaire   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling

Nature Communications
Interleukin-1β (IL-1β) is a key inflammatory mediator in cancer. Its precursor, Pro-IL-1β, is conventionally considered inactive. Here we demonstrate that head and neck squamous cell carcinoma (HNSCC) cells exhibit significantly elevated Pro-IL-1β ...
Quanzhu Chen, Pan Wu, Jing Cai, Xingxing Lu, Zhaojian Gong, Pan Chen, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, Mei Yi, Bo Xiang   +10 more
doaj   +1 more source

IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells. [PDF]

PLoS ONE, 2011
Earlier, we have shown that GM-CSF-exposed CD8α- DCs that express low levels of pro-inflammatory cytokines IL-12 and IL-1β can induce Foxp3+ Tregs leading to suppression of autoimmunity.
Balaji B Ganesh, Palash Bhattacharya, Anupama Gopisetty, Jianrong Sheng, Chenthamarakshan Vasu, Bellur S Prabhakar   +5 more
doaj   +1 more source

Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability. [PDF]

, 2016
Monocytes play a central role in regulating inflammation in response to infection or injury, and during auto-inflammatory diseases. Human blood contains classical, intermediate and non-classical monocyte subsets that each express characteristic patterns ...
A MacKenzie, A Piccini, AA Sharma, AM Knapinska, AM Zawada, B Passlick, C Antonopoulos, CA Dinarello, D Kontoyiannis, D Perregaux, DJ Stumpo, E Carballo, E Shantsila, E Vigano, E Wang, F Martinon, G Buell, G Laroia, G Shaw, GM Wilson, IA Vlasova, J Cros, J Maelfait, JA Hagar, JH Edwan, JR Ward, JY Lu, JY Lu, KL Wong, KL Wong, KS Sinsimer, L Ziegler-Heitbrock, M Alfaidi, ME Edye, MG Netea, N Kayagaki, N Marina-Garcia, N Sadri, P Ancuta, P Ivanov, P Pelegrin, P Pelegrin, P Pelegrin, RA Black, RG Snodgrass, SD Wright, T Kastelic, T Takenouchi, T Takenouchi, VA Rathinam, WP Arend, Y Qu, YL Chen, ZJ Shen   +53 more
core   +1 more source