Results 141 to 150 of about 2,610,317 (379)

C/EBPβ Acts Upstream of NF-κB P65 Subunit in Ox-LDL-Induced IL-1β Production by Macrophages

Cellular Physiology and Biochemistry, 2018
Background/Aims: Interleukin-1β (IL-1β) is one of the critical inflammatory factors during atherogenesis. CCAAT/enhancer binding proteins β (C/EBPβ), a regulator of IL-1β production, recently been evidenced as a key player in the development of ...
Jun Ma, Chuan Liu, Yuanqi Yang, Jie Yu, Jie Yang, Sanjiu Yu, Jihang Zhang, Lan Huang   +7 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The effect of oxidative stress and glucocorticoids on TGF-ß1 production in airway epithelial cells

, 2010
Transforming growth factor-β1 (TGF-β1) is implicated in inflammation and airway wall remodeling in inflammatory airway disease. Oxidative stress has also been implicated in the pathogenesis of inflammatory lung disorders. Reactive oxygen species (ROS),
Chou, Pai Chien, Chou, Pai Chien
core   +1 more source

The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells [PDF]

, 2008
Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix.
Corps, Anthony N., Curry, Valerie A., Harrall, Rebecca L., Hazleman, Brian L., Jones, Gavin C., Riley, Graham P.   +5 more
core   +2 more sources

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

Cell Death and Disease, 2018
Astrocytes are known to be critical regulators of neuronal function. However, relatively few mediators of astrocyte to neuron communication have been identified.
A. D. Chaudhuri, Raha M. Dastgheyb, Seung-Wan Yoo, A. Trout, C. Talbot Jr., Haiping Hao, K. Witwer, N. Haughey   +7 more
semanticscholar   +1 more source

Hyperuricemia and Pro Inflammatory Cytokine (IL-1β, IL-6, and TNF-α)

Indonesian Journal of Rheumatology, 2018
Background. Rugerio et al 2006 reported that there were a positive correlation between the level of hyperuricemia and the level of IL-1β, IL-6, and TNF-α pro infl ammatory cytokines value. On the other hand, Choi et al reported a negative correlation between hyperuricemia and the level of pro infl ammatory cytokine in the late phase of hyperuricemia.
Hadi, Suyanto, Sudarsono, D, Suntoko, Bantar   +2 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat

Anais da Academia Brasileira de Ciências, 2016
The contribution of Interleukin-1β (IL-1β) to neuronal injury induced by status epilepticus (SE) in the immature brain remains unclear. The goal of this study was to determine the hippocampal expression of IL-1β and its type 1 receptor (IL-1RI) following
Dulce-Mariely Álvarez-Croda, Juan Santiago-García, Jesús S. Medel-Matus, Joel Martínez-Quiroz, Angel A. Puig-Lagunes, Luis Beltrán-Parrazal, María-Leonor López-Meraz   +6 more
doaj   +1 more source

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity. [PDF]

, 2013
Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function.
A Blum, A Didierlaurent, A Gratchev, A So, A Terashima, AE Price, AH Lichtman, AM Miller, AM Owyang, AR Satoskar, B Bresnihan, Benjamin J. Marsland, C Dostert, CA Dinarello, CA Dinarello, CI Sandborg, CM Larsen, CT Weaver, D Perregaux, DB Sutherland, DR Neill, E Von Stebut, EA Miao, F Martinon, FG Monroy, FR Homaidan, GW Varilek, H Helmby, H McSorley, H Spits, Ilaria Mosconi, J Brynskov, J Schmitz, J Schmitz, J Urban, J Urban, JA Kummer, JC Massacand, JL Barlow, JM Behnke, JR Grainger, K Ikeda, K Mohrs, K Moro, K Smith, K Yasuda, KD McCoy, Kendle M. Maslowski, KR Youngman, LA Greenbaum, M Cappello, M Geuking, M Hepworth, M Kool, M Labow, M Ligumsky, M Rank, M Ritter, M Townsend, M Willart, M Wilson, M Yamamoto, Mario M. Zaiss, Mark Wilson, MM Fort, MR Hepworth, MS Pereira, N Harris, Nadine Guenat, NE Humphreys, NE Humphreys, Nicola L. Harris, NR de Silva, O Adachi, O Gross, P Broz, P Mombaerts, PG Fallon, R Anthony, R Caruso, R Horai, RH Whitehead, RJ Greenwald, RM Anthony, RM Fleischmann, S Mariathasan, SA Saenz, SD Hurst, Y Sonobe, Y-H Wang, Z Kang   +90 more
core   +4 more sources